ID E0VVT4_PEDHC Unreviewed; 520 AA.
AC E0VVT4;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Ecdysone receptor {ECO:0000256|ARBA:ARBA00022052};
DE AltName: Full=20-hydroxy-ecdysone receptor {ECO:0000256|ARBA:ARBA00029963};
DE AltName: Full=EcRH {ECO:0000256|ARBA:ARBA00030794};
DE AltName: Full=Ecdysteroid receptor {ECO:0000256|ARBA:ARBA00033003};
DE AltName: Full=Nuclear receptor subfamily 1 group H member 1 {ECO:0000256|ARBA:ARBA00033286};
GN Name=8238728 {ECO:0000313|EnsemblMetazoa:PHUM467460-PA};
GN ORFNames=Phum_PHUM467460 {ECO:0000313|EMBL:EEB17490.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB17490.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17490.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB17490.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17490.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007829|PDB:4OZR, ECO:0007829|PDB:4OZT}
RP X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 281-518.
RX PubMed=25004972; DOI=10.1107/s1399004714009626;
RA Ren B., Peat T.S., Streltsov V.A., Pollard M., Fernley R., Grusovin J.,
RA Seabrook S., Pilling P., Phan T., Lu L., Lovrecz G.O., Graham L.D.,
RA Hill R.J.;
RT "Unprecedented conformational flexibility revealed in the ligand-binding
RT domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle
RT (USP) subunits.";
RL Acta Crystallogr. D 70:1954-1964(2014).
RN [4] {ECO:0000313|EnsemblMetazoa:PHUM467460-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM467460-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR EMBL; AAZO01005680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235813; EEB17490.1; -; Genomic_DNA.
DR RefSeq; XP_002430228.1; XM_002430183.1.
DR PDB; 4OZR; X-ray; 2.70 A; E=282-514.
DR PDB; 4OZT; X-ray; 2.70 A; E=281-518.
DR PDBsum; 4OZR; -.
DR PDBsum; 4OZT; -.
DR AlphaFoldDB; E0VVT4; -.
DR SMR; E0VVT4; -.
DR STRING; 121224.E0VVT4; -.
DR EnsemblMetazoa; PHUM467460-RA; PHUM467460-PA; PHUM467460.
DR GeneID; 8238728; -.
DR KEGG; phu:Phum_PHUM467460; -.
DR CTD; 8238728; -.
DR VEuPathDB; VectorBase:PHUM467460; -.
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_12_4_1; -.
DR InParanoid; E0VVT4; -.
DR OMA; NNCDIDM; -.
DR OrthoDB; 5390715at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035100; F:ecdysone binding; IEA:InterPro.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0035076; P:ecdysone receptor-mediated signaling pathway; IEA:InterPro.
DR CDD; cd07161; NR_DBD_EcR; 1.
DR CDD; cd06938; NR_LBD_EcR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR003069; Ecdystd_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR041889; NR_LBD_EcR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF331; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 3; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01283; ECDYSTEROIDR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4OZR, ECO:0007829|PDB:4OZT};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 149..224
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 287..520
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 24..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..82
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 58220 MW; 440D0705977D6743 CRC64;
MFRGGASAMK PIGNCEEDLV LTQVKSEPRV HSPCEKDMTP SASSNQSNSL FSTISSSSKR
PRTDDWLSPP SPGPPMGSAP LTPSPGPHNQ YTVISNGYSS PMSSGSYDPY SPNGKLGRED
LSPPGSLNGY SVDSSDSKKK KGPTPRQQEE LCLVCGDRAS GYHYNALTCE GCKGFFRRSI
TKNAVYQCKY GDSCEIDMYM RRKCQECRLK KCLSVGMRPE CVVPEIQCEV KRREKKAQRE
KGKPSSTTNG SPELIMADTP AIKTEPNTTQ SHNEKSSANG VKPISPEQEE LIHRLVYFQN
EYEQPSDEDL KRISNAPSEG EDQSDLNFRH ITEITILTVQ LIVEFAKRLP GFDKLLREDQ
IALLKACSSE VMMLRMARRY DVGSDSILFA NNQPYTRDSY SLAGMGETVD DLLRFCRQMY
GMKVDNAEYA LLTAIVIFSE RPSLIEGWKV EKIQEIYLEA LKVYVDNRRK PRSGTIFAKL
LSVLTELRTL GNLNSEMCFS LKLKNKKLPP FLAEIWDVIP
//