GenomeNet

Database: UniProt
Entry: E0VVT4_PEDHC
LinkDB: E0VVT4_PEDHC
Original site: E0VVT4_PEDHC 
ID   E0VVT4_PEDHC            Unreviewed;       520 AA.
AC   E0VVT4;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 91.
DE   RecName: Full=Ecdysone receptor {ECO:0000256|ARBA:ARBA00022052};
DE   AltName: Full=20-hydroxy-ecdysone receptor {ECO:0000256|ARBA:ARBA00029963};
DE   AltName: Full=EcRH {ECO:0000256|ARBA:ARBA00030794};
DE   AltName: Full=Ecdysteroid receptor {ECO:0000256|ARBA:ARBA00033003};
DE   AltName: Full=Nuclear receptor subfamily 1 group H member 1 {ECO:0000256|ARBA:ARBA00033286};
GN   Name=8238728 {ECO:0000313|EnsemblMetazoa:PHUM467460-PA};
GN   ORFNames=Phum_PHUM467460 {ECO:0000313|EMBL:EEB17490.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC   Pediculus.
OX   NCBI_TaxID=121224;
RN   [1] {ECO:0000313|EMBL:EEB17490.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB17490.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB17490.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB17490.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0007829|PDB:4OZR, ECO:0007829|PDB:4OZT}
RP   X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 281-518.
RX   PubMed=25004972; DOI=10.1107/s1399004714009626;
RA   Ren B., Peat T.S., Streltsov V.A., Pollard M., Fernley R., Grusovin J.,
RA   Seabrook S., Pilling P., Phan T., Lu L., Lovrecz G.O., Graham L.D.,
RA   Hill R.J.;
RT   "Unprecedented conformational flexibility revealed in the ligand-binding
RT   domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle
RT   (USP) subunits.";
RL   Acta Crystallogr. D 70:1954-1964(2014).
RN   [4] {ECO:0000313|EnsemblMetazoa:PHUM467460-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM467460-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU004334}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR   EMBL; AAZO01005680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS235813; EEB17490.1; -; Genomic_DNA.
DR   RefSeq; XP_002430228.1; XM_002430183.1.
DR   PDB; 4OZR; X-ray; 2.70 A; E=282-514.
DR   PDB; 4OZT; X-ray; 2.70 A; E=281-518.
DR   PDBsum; 4OZR; -.
DR   PDBsum; 4OZT; -.
DR   AlphaFoldDB; E0VVT4; -.
DR   SMR; E0VVT4; -.
DR   STRING; 121224.E0VVT4; -.
DR   EnsemblMetazoa; PHUM467460-RA; PHUM467460-PA; PHUM467460.
DR   GeneID; 8238728; -.
DR   KEGG; phu:Phum_PHUM467460; -.
DR   CTD; 8238728; -.
DR   VEuPathDB; VectorBase:PHUM467460; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_12_4_1; -.
DR   InParanoid; E0VVT4; -.
DR   OMA; NNCDIDM; -.
DR   OrthoDB; 5390715at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0035100; F:ecdysone binding; IEA:InterPro.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0035076; P:ecdysone receptor-mediated signaling pathway; IEA:InterPro.
DR   CDD; cd07161; NR_DBD_EcR; 1.
DR   CDD; cd06938; NR_LBD_EcR; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR003069; Ecdystd_rcpt.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR041889; NR_LBD_EcR.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24082:SF331; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 3; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01283; ECDYSTEROIDR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4OZR, ECO:0007829|PDB:4OZT};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004334};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004334};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004334};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT   DOMAIN          149..224
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          287..520
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          24..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..82
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  58220 MW;  440D0705977D6743 CRC64;
     MFRGGASAMK PIGNCEEDLV LTQVKSEPRV HSPCEKDMTP SASSNQSNSL FSTISSSSKR
     PRTDDWLSPP SPGPPMGSAP LTPSPGPHNQ YTVISNGYSS PMSSGSYDPY SPNGKLGRED
     LSPPGSLNGY SVDSSDSKKK KGPTPRQQEE LCLVCGDRAS GYHYNALTCE GCKGFFRRSI
     TKNAVYQCKY GDSCEIDMYM RRKCQECRLK KCLSVGMRPE CVVPEIQCEV KRREKKAQRE
     KGKPSSTTNG SPELIMADTP AIKTEPNTTQ SHNEKSSANG VKPISPEQEE LIHRLVYFQN
     EYEQPSDEDL KRISNAPSEG EDQSDLNFRH ITEITILTVQ LIVEFAKRLP GFDKLLREDQ
     IALLKACSSE VMMLRMARRY DVGSDSILFA NNQPYTRDSY SLAGMGETVD DLLRFCRQMY
     GMKVDNAEYA LLTAIVIFSE RPSLIEGWKV EKIQEIYLEA LKVYVDNRRK PRSGTIFAKL
     LSVLTELRTL GNLNSEMCFS LKLKNKKLPP FLAEIWDVIP
//
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