ID E0VWG7_PEDHC Unreviewed; 2620 AA.
AC E0VWG7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Highwire, putative {ECO:0000313|EMBL:EEB17723.1, ECO:0000313|EnsemblMetazoa:PHUM483630-PA};
GN Name=8231413 {ECO:0000313|EnsemblMetazoa:PHUM483630-PA};
GN ORFNames=Phum_PHUM483630 {ECO:0000313|EMBL:EEB17723.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB17723.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17723.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB17723.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB17723.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM483630-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM483630-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; AAZO01005861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235820; EEB17723.1; -; Genomic_DNA.
DR RefSeq; XP_002430461.1; XM_002430416.1.
DR STRING; 121224.E0VWG7; -.
DR EnsemblMetazoa; PHUM483630-RA; PHUM483630-PA; PHUM483630.
DR GeneID; 8231413; -.
DR KEGG; phu:Phum_PHUM483630; -.
DR CTD; 8231413; -.
DR VEuPathDB; VectorBase:PHUM483630; -.
DR eggNOG; KOG1428; Eukaryota.
DR HOGENOM; CLU_000281_0_0_1; -.
DR InParanoid; E0VWG7; -.
DR OMA; IKYAIRL; -.
DR OrthoDB; 167377at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd08682; C2_Rab11-FIP_classI; 1.
DR Gene3D; 1.20.5.2440; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.60.120.820; PHR domain; 2.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037245; FIP-RBD_C_sf.
DR InterPro; IPR012983; PHR.
DR InterPro; IPR038648; PHR_sf.
DR InterPro; IPR019018; Rab-bd_FIP-RBD.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45943; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR PANTHER; PTHR45943:SF1; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF08005; PHR; 2.
DR Pfam; PF13540; RCC1_2; 3.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF144270; Eferin C-derminal domain-like; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51511; FIP_RBD; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 1..106
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 441..503
FT /note="FIP-RBD"
FT /evidence="ECO:0000259|PROSITE:PS51511"
FT REPEAT 1358..1407
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REGION 213..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1254..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..250
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2620 AA; 287698 MW; 3296033C37767266 CRC64;
MLSITHAHVT ILQADNLLIK GKNGTNNAFV VIELGKEIYR TSVKENSGRS VVWNEECELK
IPKIGNKASI VLTAQHRNSF GLDQFLGMVK IPLDSFDKTE KRVKWFKLDG KPGKNKDDDK
TRGKLEVQIG FLSKGGGQSI SLTSLPSKKK TVIEKLTGSL YGLTHIDQKK NKTMGVSKIA
RSLQKMAFKK KQKPVVEEEE DEAEDEFVDG INDSTLCGSC PPTRKANTPN NLDPGVISED
EEEEDEENSQ KSFDDGCWVK NGKVVSCSPK TTQKLYKQNP QISISFCDDD SNNSNNNNNK
NSNKKNKSKM NQSASVCDIR TESLKNTLSS QKRKKSPKLG ELNGGGLRLS ARRLSASCVD
FHDFSTPVLE KKFTSLYLDA NLQVDNGSNK KKSKLVKKLK QFRSFDYYSK ESKEVRRTVI
GCEAGDKMEE MTSSPSPSPS PSSSFYSNKS EFKNKTKDEL IKMILDLQKK VNCVTMRVKE
LENYLDGILS KVMETVPKLL EKQSDWGKKR KRKWENFYKK KNKDGSETSI GPPEVKLNGN
PSEFAVFAHV RQAVLEAWSH KASQIYLNSS SSIPILESAY EGESDSDVTE IYHPQLPRVP
KIVGVGLRCV LEIIKDSRQS HPVLCTRALA ALLDVLQGQQ PQGLQNEPAE VIDPLFDLLL
DLATCYTPDS STSDDGNHLT AIACSCLLSL VIVRGSTGKL LSAAAALLMC PKQLANQNIH
LPLVMTALQR SIYAVLLGKI SRPDWLTHGV PKASKIDSFP IKNTGLGVVR SLASDGQYLY
LYSSRGLFKI GSGHGGTIKG HIYYCVPDFF HDDKGWLGFA NGWLWLKVAG KRGCELLRID
RNPFKVVNTV RLDTRDWSPS VWFSDADQIG VITSTNEDGF VVKTLNPNVK PVTITSELSL
KLARKCIDVM GSSSFDEDSG NKTLNFDFDD EILSIVSGKE FGLIRTTSGK VFYSGKASSI
GMKSGVSSGR WSELVMPKGA KAQHISVGHE GLHAIIVAED GSVFFCGTAR RGEDGDLNKA
RRQPKAVKPK KMVKVEDEYI VHAATNNGTT ALVTRNGQLL MFGKDTVHCN SSTGKVLGIE
NLHITQVALG KAHAVALTSK GIVYTFGINN KGQCGRDFVT QIKEAIAMDT VVQEEEKEDE
IDWEDAQNIM CLPGKHQWRH DLCMVCTVCK ECTGYSISCL SSIRPQRNPG QECGCGEGDS
GCSICGCCRV CAKEYVDNSD LAVLGPSGLG DSSGMMRLDL IFSGDSQEHL QKRLEERKQR
QGRKTSSKHN CSLKIKSSGS RPSVSSSKSG SSIPIFKTPA PIKFSNLINE EVAGGSDLER
DTSRVTSLPP APIALPYTCP VTQIACGLHH SIVLTQSGEV YTFGSNIYGQ LGIGDVLLRG
GPVSVRLPCP AQSVAAGSNH TIILTVKGEV YTFGSHQKGQ LGRKSFKGHN DPSTSTTFGR
KNNCYARHET PWYAIPGPVP GIGPNSGRRA TWIGAAGDQT FIKVDESLIN SLSLEQSTIT
GNKSCILPKC ENNTFQSLAI SRRDGNCAVF SDAGQAHLIG SPVCLDPLYN VLWSYQQSTN
LISCYNIIAS EAKGLEALSH SMFDPDLVLP ITPGCLVKRS QAALHLLGAL DTLAQAQHFK
LEVGSEILEK QMGTTKAYTL QDFSAVNRFE SHGGGWGYSG HSVEAIRFMA DADIILGGFG
LFGGRGEYTA KIKLLDIGVD GGEQESDGEV IAETDDIPYE CGPRQKYPML FEEPLLLQGN
RWYIAWARIS GPSSDCGSNG QAVIVTEDQI SFYFKSSKKS NNGTDVNAGQ IPQLLYKVIT
QETKAPPRQI DLSEPVFVLS KEFSSTVTSE CFKSLLALLH WGWKALKSGY LDLNGSISTM
STHAEHERLT RLVYINRASL RLIHLFTIEI YPDQIFSKKT VSESVRLAES IGDVRALLQK
ILSDKPINGA HKELTDAVLE ECHKTLVSIF HALYPTPFLK WTCLCDLLSK TDKTGFYYTQ
HDKLLSAVLE ALCCPTVRLR SALPILTNSL DPSMRQLSPS DNSGFTVSGT DHHYPLLVEQ
MSYRTQLEKN GETIVNWSWK EVLDKLLDLC ILPPKRDLMQ KHSNLSKELV KNCCNLLARV
VAELASQSCG SDEDIQGSCG RVLHATPSRF MRTNQTRTWN TGNGSPDAIC FSVDKPGVVI
AGACVYGGMG VLEYELELLD DQSNSACGDP SPAQRWTTLE VIKGTFGPDD CVSDIAELKF
AKPVPIKENV KYAIRLRNQG GRTSNGDGGL NTVKGPDGIT FSFSTCSLSF NGTTQTRGQI
PQILYYSNPQ DGSFQHTAKA IAEQQARKST LSMTTAIFNR CSTLLSMARE KAEDLNVIKI
LGNACAITTL LPLVLAHVGP LGTSDPRSAV QIINLVQDLL PHVSALNLLG NNSDDLPKST
TSNHYAWVES DHPYKPASVS NYRVLFPESV KWMVVEFSPR CGTAQVEDLL KLYIPSAIKE
IWDRQYEDFE NDSMTPLTYW KVFRTLRGGT TWPQDAVVLP GNEVIFSLET ASDYVKNEKA
CNYGFRCLVV GYEWDSSHGN GLKQIESELS FTAGMCAASL IKKDLQLPLL TVEEAEEDTD
LAEEAVMMVA NEHSSLLVRG LALAQTPTIF QALDGSLPFR
//
