ID E0VXZ2_PEDHC Unreviewed; 635 AA.
AC E0VXZ2;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN Name=8232968 {ECO:0000313|EnsemblMetazoa:PHUM506720-PA};
GN ORFNames=Phum_PHUM506720 {ECO:0000313|EMBL:EEB18248.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB18248.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18248.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB18248.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18248.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM506720-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM506720-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
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DR EMBL; AAZO01006167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235842; EEB18248.1; -; Genomic_DNA.
DR RefSeq; XP_002430986.1; XM_002430941.1.
DR AlphaFoldDB; E0VXZ2; -.
DR STRING; 121224.E0VXZ2; -.
DR EnsemblMetazoa; PHUM506720-RA; PHUM506720-PA; PHUM506720.
DR GeneID; 8232968; -.
DR KEGG; phu:Phum_PHUM506720; -.
DR CTD; 8232968; -.
DR VEuPathDB; VectorBase:PHUM506720; -.
DR eggNOG; KOG0509; Eukaryota.
DR HOGENOM; CLU_012510_3_1_1; -.
DR InParanoid; E0VXZ2; -.
DR OMA; FWVGFRY; -.
DR OrthoDB; 33889at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24161:SF17; PALMITOYLTRANSFERASE HIP14; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF01529; DHHC; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|RuleBase:RU079119};
KW Oxidoreductase {ECO:0000313|EMBL:EEB18248.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 323..345
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 357..374
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 380..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 476..498
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT REPEAT 84..116
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 118..150
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 151..183
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 219..251
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 429..562
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
SQ SEQUENCE 635 AA; 71852 MW; 5C9CAD6B9407092C CRC64;
MNKLEKLQTL SGSCSAGSTI KYGGCADDYG NTSVIFQEPA EKIDASKEVD HSNLDIVKAT
QFGALNRVKE LIEAGYDVNQ PDSETVTLLH WAAINNRKEL IKYFVELGAV VDAIGGVLQS
TPLHWATRQG YLQSVTLLMK FGADPSLKDG EGCSCLHLAA QFGHTAIVAY LVAKGLSPNL
QDKYGMTPLM WSSYKVSSLD PTRLLLTLGA CSGAQDKFYG NTALHWAIKA KNHVAVNILV
MSGADLHIPN NQGFTPFSMI SKDKTPNWVG KKVLEKIQED VPSSEFFLKR LIRDKRLRYW
CMLATPFIGF YIVGLVMQSN QDYLVKLGLI LVFYIFIYFA GKVFFDDRLT TVLPMSLYLA
TKFWMYITWC LYIAPKCSIL LSVIFISFSL LLWFYFIKSW KGDPGVITYT QEEKFRTIIE
LAENDGFERQ WFCSTCLVRR PIRSKHCAMC NRCVAKFDHH CPWVGNCIGA KNHKYFIGYL
CMLLVMCVLV IHGATVYWNA VCKITPISES FWTAVGDCLS CEGWVSWVAV NALLHSVWVA
SLLCCQMYQI SCLGMTTNER MNVGRYKHFH TVNDVKSTKS PFDHGPCQNI IDLLGIRCFG
LFNPDYTDWM TQYQLIEKIE IAPLLPEKDN NYQYV
//
