ID E0VYD0_PEDHC Unreviewed; 1389 AA.
AC E0VYD0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Class B secretin-like G-protein coupled receptor GPRoca2, putative {ECO:0000313|EMBL:EEB18386.1};
GN Name=8233108 {ECO:0000313|EnsemblMetazoa:PHUM512990-PA};
GN ORFNames=Phum_PHUM512990 {ECO:0000313|EMBL:EEB18386.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB18386.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18386.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB18386.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18386.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM512990-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM512990-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAZO01006244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235845; EEB18386.1; -; Genomic_DNA.
DR RefSeq; XP_002431124.1; XM_002431079.1.
DR STRING; 121224.E0VYD0; -.
DR EnsemblMetazoa; PHUM512990-RA; PHUM512990-PA; PHUM512990.
DR GeneID; 8233108; -.
DR KEGG; phu:Phum_PHUM512990; -.
DR CTD; 8233108; -.
DR VEuPathDB; VectorBase:PHUM512990; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_002387_0_0_1; -.
DR InParanoid; E0VYD0; -.
DR OMA; YNICFIT; -.
DR OrthoDB; 2900279at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR PANTHER; PTHR45930:SF4; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EEB18386.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1389
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011412751"
FT TRANSMEM 597..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 842..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..331
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 316..407
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 594..897
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1050..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1389 AA; 156691 MW; 34E84FCCD93DC126 CRC64;
MLLMKIWFYC LFFIIQNSII IRAEQKISVD CPAKCTCNII RAKDSGSSSE EWSKVKCGRN
HYEKLFIEDL KLNEVEPHIL QLELALNITV LENSFLKLIS LEKLDLSKNG IEEIDDKAFI
HLTNLKKLDL SNNKISILHK KIFEPLQYLE RLKINNNLIT HVYRGVFDYL TSLRSLDISE
NPLNCDCSLI WIIEWSKNNL IKLMQLPKCK SPHSNKEILL RKLKLDCEEE SSFYSKSFKL
ELKPMHNQIV FEGDSLNLRC RNEGKDAQVT WSWKNKDPTS YFDKIKIENQ SVVENGFVES
QLKIDKIQKS HGGDWHCHLL SESGNHSSSI SVIVLSDDSK YCPQTETKNN KGMYLWPKTI
GGFTVDLPCA VKQLSIVGKK IEPRAIHSCN EAGFWENLNT TFCPYVSETT RILEQFSQVN
LSIAKGSVLD SALKLKNFTG TGENLTDVMD IVFISKTIEN YLMFVKQEKD LGYVLVDIVA
KIMELSKNLL KNAQKEDASC SKLVQSLEYR SIFRDKMHLV YKYSCMYENN NLFPSLSNSN
EDVTSCVIGC QSSHYTHGMV VFHCNRFGYF GLLQDTRYLY EYSRGYNGGK SRLCHPAIYT
GSFILIVCLL TSFITYVISH SFIQMSRRAK HAVVNTWISI SLLCFIFSCG IYQTGNAALC
QSIGIVLHYL FLSTLLWMTV SASNMYKRLS KADSLDTTPE DDLPPGAPIQ KPILGLYLVG
WGIGLIVCGI SGAVNLKEYA GRKFCFLEFG PALSAVYVPA GMLFSFLILL YILTLCAIRN
NDLNGQLSEG TQGTENVDLE LLEVPPVLNT TDRRSVQSIV TTDSDDIEDP EHSPIIQLKA
HIIVLLLYCF ICILAALSLV ENMPNTFFYQ QEICSILYCL LSFCLGAFIL YFYCVARSDV
RSQWTILKKV FKGQKFHCCR SRSVSDTHGN VQMTSSVNIP NGSNARHTVS ALSSSSVNSS
ALTAKSNSHN SNRIKAVKKL NNCDSLKEPM SVHSSTANNV NLVAMHRQMY RSNISVPNYR
EIIGPDCAEA FYNPRQSIVA RKFFKKQRRN KRNDLGLRRR GDGGGTSEGE ASQARRTWRP
SAESAVFLSS DMENVNEKGD GNHFVYKCKL NSGNNHLPNE RIKKSVSSKK NNGELMMSDS
DGENKIPLDR LVIGAEEEMG GKLPVVKTNN GHVSSYDCCL SRVDELSASE DMTFSPAISK
DADKELLSEN SAVGHSPCCD CNDLNNLSNY RNVELQCSLG ENSCSDINSE MNYCECGVNV
DSHYADDNGY NFSDKCNNVR HSNEHDNDDN SMISTDDVLN CDSFNKKIDE FNLNTDSQRF
DDELLLYNKT DSSLNLNNSA RQCTNVLNTQ INNCNSVKNM SIQSECENEK ESLINFNEIN
DKTKKETSV
//