ID E0VYM7_PEDHC Unreviewed; 399 AA.
AC E0VYM7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Class A rhodopsin-like G-protein coupled receptor GPRdop2, putative {ECO:0000313|EMBL:EEB18483.1, ECO:0000313|EnsemblMetazoa:PHUM515970-PA};
DE EC=2.7.10.2 {ECO:0000313|EMBL:EEB18483.1};
GN Name=8233205 {ECO:0000313|EnsemblMetazoa:PHUM515970-PA};
GN ORFNames=Phum_PHUM515970 {ECO:0000313|EMBL:EEB18483.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB18483.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18483.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB18483.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18483.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM515970-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM515970-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AAZO01006275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235845; EEB18483.1; -; Genomic_DNA.
DR RefSeq; XP_002431221.1; XM_002431176.1.
DR AlphaFoldDB; E0VYM7; -.
DR STRING; 121224.E0VYM7; -.
DR EnsemblMetazoa; PHUM515970-RA; PHUM515970-PA; PHUM515970.
DR GeneID; 8233205; -.
DR KEGG; phu:Phum_PHUM515970; -.
DR CTD; 8233205; -.
DR VEuPathDB; VectorBase:PHUM515970; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_1_1; -.
DR InParanoid; E0VYM7; -.
DR OMA; WCDIWHS; -.
DR OrthoDB; 4073525at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd15067; 7tmA_Dop1R2-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF185; DOPAMINE RECEPTOR 2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:EEB18483.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transferase {ECO:0000313|EMBL:EEB18483.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..387
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 399 AA; 45411 MW; 243B624574FC1F7B CRC64;
MNDSLWNLVE TEEDLLIQVV SNGIHKSSEI ENVTWSNITL KNYTEVDWEK MAQERAVLGI
ILGLFSVATV FGNVLVILAV ARERYLHTST NYFVTSLAVA DCLVGLVVMP FSATHEVFVH
NWYFGTDWCD VWRSLDVLFS TASILNLCVI SLDRYWAITD PFTYPMRMSR KKAAALIAGV
WVCSATISFP AIAWWRAVQV KEPPPLTCPF TENFGYLMFS STISFYLPLF VMVFTYYRIY
RAAAEQTRSL KLGTKQVLMA SGELELTLRM HRGGNHQIYQ HVDDGTDDVE ISPPHNGLSR
MPSSKFSTKN FSKNFSVSRK LAKFAKEKKA AKTLGIVMGV FIVCWLPFFV VNLLSGICNQ
CIWQEELVSS IVTWLGWINS SMNPVIYACW SRDFRRCHN
//
