ID E0VZL7_PEDHC Unreviewed; 647 AA.
AC E0VZL7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Xaa-Pro aminopeptidase, putative {ECO:0000313|EMBL:EEB18823.1, ECO:0000313|EnsemblMetazoa:PHUM536060-PA};
DE EC=3.4.11.9 {ECO:0000313|EMBL:EEB18823.1};
GN Name=8235306 {ECO:0000313|EnsemblMetazoa:PHUM536060-PA};
GN ORFNames=Phum_PHUM536060 {ECO:0000313|EMBL:EEB18823.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB18823.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18823.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB18823.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18823.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM536060-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM536060-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; AAZO01006507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235853; EEB18823.1; -; Genomic_DNA.
DR RefSeq; XP_002431561.1; XM_002431516.1.
DR AlphaFoldDB; E0VZL7; -.
DR STRING; 121224.E0VZL7; -.
DR EnsemblMetazoa; PHUM536060-RA; PHUM536060-PA; PHUM536060.
DR GeneID; 8235306; -.
DR KEGG; phu:Phum_PHUM536060; -.
DR CTD; 8235306; -.
DR VEuPathDB; VectorBase:PHUM536060; -.
DR eggNOG; KOG2413; Eukaryota.
DR HOGENOM; CLU_011781_2_2_1; -.
DR InParanoid; E0VZL7; -.
DR OMA; IRTYVQI; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF4; XAA-PRO AMINOPEPTIDASE 2; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:EEB18823.1};
KW Hydrolase {ECO:0000313|EMBL:EEB18823.1};
KW Protease {ECO:0000313|EMBL:EEB18823.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 14..128
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 314..531
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 544..608
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 647 AA; 73665 MW; CBD61A41CB1BBD35 CRC64;
MSRMTSVRGP ILNAFIITSD DEHQSEFLSD RDKKLEYISG FTGMYGYAVI TKSSAALWTT
EKFYALADQQ LDCNWELMKL GEPGVPSLTE WLKKVLKRGL YRVGADPRMI PSSTWEEWNR
ELAADKLVLT EVPNNLIDLI WTIGRPPYNP YPAFVLPQEY AGESWQSKVI NLRHNLTRFG
CDAMIVTALE EIAWLLNIRG RDTNYNPFVK AYLIVERERL RLYVPKEKVS DDIRRQLRVE
SHGSLSVRLF PYDAVFTELR TLSQAWDKVL IPSTWFYSSG ASQAIVLAVP PEKRFLRQSP
IILMKAKKNS AECEGMRAAN LRDSAAFVDF LALMDEEIKL STNWTEVDVV NTLDKFRSEQ
NLNQGVPFPT VATYGHHGGF FYYETNNKTN LKLEDSSTLV IESGGHYFDG TSEVVRTFHF
GEPTRDMIEY YTKILSALIQ FSTATFPVTA KTTDLDTIVR SKLWKSGINY KMDLGHGLGS
FSNVYESPIV INSDSKQHRQ TIREGYFLTC QPSYVKPYKY GLKLGNVLEV TSKGSNNFDG
KPSKYLEFND VTLVPFESKL IDTRLLSREE VDWLNGYHLR VMQEVGAELK RQSRMKGFYW
LMEKTKEIPY DCSSGVGGNG NSKGSILLIS VTELLIQANV AAPLKKL
//
