ID E0VZM6_PEDHC Unreviewed; 491 AA.
AC E0VZM6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Caspase-1, putative {ECO:0000313|EMBL:EEB18836.1};
DE EC=3.4.22.36 {ECO:0000313|EMBL:EEB18836.1};
GN Name=8235319 {ECO:0000313|EnsemblMetazoa:PHUM536790-PA};
GN ORFNames=Phum_PHUM536790 {ECO:0000313|EMBL:EEB18836.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB18836.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18836.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB18836.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18836.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM536790-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM536790-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR EMBL; AAZO01006521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235853; EEB18836.1; -; Genomic_DNA.
DR RefSeq; XP_002431574.1; XM_002431529.1.
DR AlphaFoldDB; E0VZM6; -.
DR STRING; 121224.E0VZM6; -.
DR EnsemblMetazoa; PHUM536790-RA; PHUM536790-PA; PHUM536790.
DR GeneID; 8235319; -.
DR KEGG; phu:Phum_PHUM536790; -.
DR CTD; 8235319; -.
DR VEuPathDB; VectorBase:PHUM536790; -.
DR eggNOG; KOG3573; Eukaryota.
DR HOGENOM; CLU_555883_0_0_1; -.
DR InParanoid; E0VZM6; -.
DR OMA; GSHADIH; -.
DR OrthoDB; 3581637at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR10454; CASPASE; 1.
DR PANTHER; PTHR10454:SF196; CASPASE-RELATED; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EEB18836.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 223..347
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 369..441
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 54913 MW; DADC8B20DA820769 CRC64;
MKRLEKVDKN VNKSSSIDNG NEREELSESI IRNISKAFYI NSIELVDNGP FIFNDDLRYG
GTNLDDDVFI EKEKEFSCGG SQVSVTKKDF HYERSERRLS SSNEDGGKSE SYGQGSRRAS
DVIDSIGDDC VNLRRSLESG GIAIASPRNR VSSDLGYSGS YTSSPAASFS YPPQMYTPSS
GGGRALNDVT DSKPFTNIYD SSGVEAVMPV DRDADEYNMY HSRRGRAIII NNDIFDNNLV
SPRKGSHVDV ENLTNEFTNL GFEVTVFSNM PYYQISEAIN EVSKEDHSDA DCLMIAVLTH
GFDNGYLYAR DTIYSIDNLW HPFTADRCLT LAGKPKIFFV QACRGSKVDS GVTLVSRKGS
VSETDAGSAA YRLPSHSDFL IAYSCPDGYY SWRNVEDGTW FVQSLVEELR KNGTTTNFLT
LLTRVNRRVA VQFSSYSEDE PWLHDKKQVS TVNDARGEDI SMFLTMNEND NKHVRVKKHI
GSKNRCDITS I
//
