ID E0W0F7_PEDHC Unreviewed; 589 AA.
AC E0W0F7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=receptor protein serine/threonine kinase {ECO:0000256|ARBA:ARBA00012401};
DE EC=2.7.11.30 {ECO:0000256|ARBA:ARBA00012401};
GN Name=8234632 {ECO:0000313|EnsemblMetazoa:PHUM551530-PA};
GN ORFNames=Phum_PHUM551530 {ECO:0000313|EMBL:EEB19113.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB19113.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19113.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB19113.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19113.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM551530-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM551530-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. TGFB receptor subfamily.
CC {ECO:0000256|ARBA:ARBA00009605}.
CC -!- SIMILARITY: Belongs to the scoloptoxin-05 family.
CC {ECO:0000256|ARBA:ARBA00025739}.
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DR EMBL; AAZO01006706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235858; EEB19113.1; -; Genomic_DNA.
DR RefSeq; XP_002431851.1; XM_002431806.1.
DR AlphaFoldDB; E0W0F7; -.
DR STRING; 121224.E0W0F7; -.
DR EnsemblMetazoa; PHUM551530-RA; PHUM551530-PA; PHUM551530.
DR GeneID; 8234632; -.
DR KEGG; phu:Phum_PHUM551530; -.
DR CTD; 8234632; -.
DR VEuPathDB; VectorBase:PHUM551530; -.
DR eggNOG; KOG2052; Eukaryota.
DR HOGENOM; CLU_000288_8_1_1; -.
DR InParanoid; E0W0F7; -.
DR OMA; VKIYFSR; -.
DR OrthoDB; 3900892at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.10.60.10; CD59; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000472; Activin_recp.
DR InterPro; IPR003605; GS_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR000333; TGFB_receptor.
DR PANTHER; PTHR23255:SF72; RECEPTOR PROTEIN SERINE_THREONINE KINASE; 1.
DR PANTHER; PTHR23255; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II; 1.
DR Pfam; PF01064; Activin_recp; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08515; TGF_beta_GS; 1.
DR SMART; SM00467; GS; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS51256; GS; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:EEB19113.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..589
FT /note="receptor protein serine/threonine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011412894"
FT TRANSMEM 187..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 256..285
FT /note="GS"
FT /evidence="ECO:0000259|PROSITE:PS51256"
FT DOMAIN 286..583
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 313
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 589 AA; 66397 MW; 07EE6F47DA5B9715 CRC64;
MASNWYILCL LFIFTSESGS VTLPPGSLVE SDSDTEIKEQ VEDNTIANEL LIKAQQEQTL
RLHKNLIRHL NRNESHEVPK FKCLSCDPPD CIPQPPCIDA YQCWKSHTRD LNGVEAVSRG
CIKKKDQVPL LCKTSSFSGV HKKRHTGGQY EVICCEEDYC NNGSFPSLPE VTFHDDVSSI
YPDKNIYILK LTLAILGPVV GLGVLGTIVL LLMRRTHKKR LERQSGLWSK ERQNGILDSD
AYYTDELVHV TAPGDSTLRE FMEHSLTSGS GSGLPLLIQR TLAKQISLSE CIGKGRYGQV
WRGVWHGENI AVKIFFSRDE ASWNRETEIY STVLLRHENI LGYIGSDMTS RNSCTQLWLV
THYHPLGSLY DHLNRTSLTH HQMMKICLTI VSGLVHLHSE IFGTQGKPAI AHRDLKTKNI
LIRMNGSCVI ADFGLAVTHV QATGQMDIAD NPRVGTKRYM APEVLEETMK TDCFESYRRA
DMYALGLVLW EVCTKTLSNG IADEYKPPYH DVVPNDPSFE DMRKVVCVDG QRPILSNRWS
SDPTLNGMGK LMKECWHQNP NVRLPALRIK KTLIKLASAD PLIHLDVDI
//
