ID E0W0H2_PEDHC Unreviewed; 723 AA.
AC E0W0H2;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=8234647 {ECO:0000313|EnsemblMetazoa:PHUM551980-PA};
GN ORFNames=Phum_PHUM551980 {ECO:0000313|EMBL:EEB19128.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB19128.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19128.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB19128.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19128.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM551980-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM551980-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; AAZO01006709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAZO01006710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235858; EEB19128.1; -; Genomic_DNA.
DR RefSeq; XP_002431866.1; XM_002431821.1.
DR AlphaFoldDB; E0W0H2; -.
DR EnsemblMetazoa; PHUM551980-RA; PHUM551980-PA; PHUM551980.
DR GeneID; 8234647; -.
DR KEGG; phu:Phum_PHUM551980; -.
DR CTD; 8234647; -.
DR VEuPathDB; VectorBase:PHUM551980; -.
DR eggNOG; KOG2514; Eukaryota.
DR HOGENOM; CLU_006685_0_1_1; -.
DR InParanoid; E0W0H2; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF83; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 284..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 363..382
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 447..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 490..515
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 645..667
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 695..714
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 71..273
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 276..711
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 723 AA; 84730 MW; FB0889E1B18B897D CRC64;
MEGIYGDSNG DLNDYDDVSM KSAKDEDFLN ASKYTVYHSA QDLDNPKVAL FQNHERPRVY
AEDEVIDEMD NKSVDFVLVW LEDYPKKANA NSNGKREVFE RNLINEGLEL SYQVLDKFHF
IKIYAPNEVL ARYCEILKLK MPIKIEETEE SEVEKFDIVN EVKNFDKKIY PPTGSKLTAE
FARDKTYLFD IDSPNFFTSG VKSCVIDFIL ERQRYTEDER AVYEVGINRL LAEGVYKAAY
PLHDVYYRKG TSLRCKLYND WSRLRNWIKI QPIDQIKDYF GVKYALYFAW LGFYTHMLIP
ASIVGLICFF YGWITLNYNT LSQDICKSDD LIMCPLCDET CDYWKLTETC TFAKLEYLFD
NPATVFFATF MSFWATLYLE LWKRHSSALT HRWGLATFDL AAEPPRPGYL VSVSSKYKKF
IKEKVNVITK MTEPYVPFWK IRVPNMVFSF SVVLLLVSTA VGAVFAVVFY RMSALSAFSL
IKPPDEQNSY TYTVIVIPAT AAVVNLICVT VLNYVKKILN RRKNYQNLKH KEKGKHNNKE
AINVILGNYV NRFNNEKYHS KYLNYYKFFR GREKYVSHSI RFCFLGFELM TTKRGSFYKN
NKYITLIGRL KKQEETPLGV NQWTEDYKLL EWGPRGLFPE YLEMIIQYGF VTIFVAAFPL
APLFALLNNI LEMRLDGQKF LKYYRRPVPR RVKNIGVWYT ILDVLIIIII IIITNRLSKL
SNY
//
