ID E0W0W5_PEDHC Unreviewed; 2024 AA.
AC E0W0W5;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Dedicator of cytokinesis protein, putative {ECO:0000313|EMBL:EEB19271.1, ECO:0000313|EnsemblMetazoa:PHUM564570-PA};
GN Name=8234790 {ECO:0000313|EnsemblMetazoa:PHUM564570-PA};
GN ORFNames=Phum_PHUM564570 {ECO:0000313|EMBL:EEB19271.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB19271.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19271.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB19271.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19271.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM564570-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM564570-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; AAZO01006860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235862; EEB19271.1; -; Genomic_DNA.
DR RefSeq; XP_002432009.1; XM_002431964.1.
DR STRING; 121224.E0W0W5; -.
DR EnsemblMetazoa; PHUM564570-RA; PHUM564570-PA; PHUM564570.
DR GeneID; 8234790; -.
DR KEGG; phu:Phum_PHUM564570; -.
DR CTD; 8234790; -.
DR VEuPathDB; VectorBase:PHUM564570; -.
DR eggNOG; KOG1997; Eukaryota.
DR HOGENOM; CLU_000624_1_0_1; -.
DR InParanoid; E0W0W5; -.
DR OMA; FPHQFND; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 570..739
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1590..2024
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 407..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2024 AA; 230054 MW; 961BF0F27EC240D9 CRC64;
MSSVQRAFTQ KLSKHNAADV RKHASLSRDN SRSCTSSLLG CITSLSINDV VEPLDYEEFI
LQNKDIIDKD PLGAIFKFPA NDIEVKVVPR SIRTEQPIIP EEPPEQWSCQ VKDSVQWLTR
DFVMINYNYR CHSTSWNIAD SLNERQELAQ LLPRQEFEID SEISNIEAPI NGKSNWDSYS
EGGSSITSDG RRSSWASLDL RHSESDKLDL KLLDRVAPEL MDQLNATSRL ENRHKEFFLL
YSSQDEEDMI EKRLQEPIPQ DSLSHNIFIK CLQLRLELDV EPIFLTLALY DAKEKKKISE
NFYTDLNSEE IKNMLSGHVE FSDISTRSRD CIFSVTHPSP DVFLVIKLEK VLQGDISECA
DPYMKDDKNK EKVKFNALAA CDRLGKYRMP FAWTAISLMN LINNENSEKD EHSSSSSNSL
DRKSSNSSLD SIKKRANMGS LTGRGSLDRY SGCDKRRSWS PEDFITGLES LRPLTITISS
FFRQESERLK DEDLYKLLQD LKRPCYLMKK LKVIPGVLKM QIAPCPDDLK YVLTPELAKV
LPYPDQKGRP VKEILEFPSR EIFLPHNTFR NLLYVYPKEL NFTNRGIRDL GSARNLTIKV
ELKSGENESL PYIFGKSCCP EFTTEAYTSV SYHNKCPSFY DEIKIKLPSK LGPQHHLFFT
LCHISCKKKP ENPPVETPVG YTWIPLLSVD RLRSGELSLP VMMEPPPSNY CYITPDVLLP
GTRWFDNHRG VFLVNIEATS SVHPQDKYLD RFLSLCASLE EGTLPPLYGE TNIETELKKS
IAELNNAKME PLVRFLPLVF DKLLTLLVRP PVVDRMTLNL GQALLESIAN LVQNITMHAV
GNKDQHNRHS LLASYIQYQC SVPALMVTDF RVGNGRMQKS SSESDLKSEF ENGIASALAR
GLDRTGSMRT GRKDENELSC APRSLLHEMI ALQWVVSSVP ARDLAMSNSW FFLELIIKSM
TETLWRLDGL DEPRQLRFSE QFCDDITMLV QTITAEIISK HNKDPKASQS LNTSVAFFIF
DLFSIMDRGL VLTLIKTYYK QMTAKTASLP DAHAHALIGY KLDFLRIVLS HEHLIPLNLP
VPIAVSGRSS PSLSVVSSNS QTSLVFNAPV SERIQMAELT SQFRSQHYLI GLLLTELNAV
LECQNPILHK KVVNIVRNLM TSHDRDSRYS DPACKARVAS LYMPLLGIIL KSLPLLHKSS
ADTTKLTHDE PESIQTKVAA LISGSAPVPI FYEMAPPSQT TQRNKGLNAE TTKHLLGCFL
WLLKNLDRDL LRNWCLESSA TSLKQLLDAF NISLHCFEYL GKKQIKYRAQ KKFGKDVDIK
AKLEDVILGQ GSARSEMIMR RKEKNPPSPD RLRWRKEQKI YKPSSEGGIC PRAQAEADAL
IEGNLATEAT LIILDTLEMI VQVACSSNSF QGQGLLGYVF GVILRALSCN QSNEALHNLF
GTQRAIVFKF PNLLFDEETE HCADLCLQLL THCSSLLSPV RAHAAASLYL LMRQNFEIGN
NFARVKMQVT MSLSSLVGTS QSYSEEALRR ALKNILVFAE EDNELRDTTF TEQVRDLVFN
LHMILSDMVK MKEFQEDPEM LLDLMYRIAK GYQNSPDLRL TWLANMAQKH MEHNNHTEAA
MCLVHSAALV AEYLHMLEDQ KHLPVGAVSF EKITPNALEE SAVSDDVLSP DEEGVCLGNY
FTESGLVGLL EHAANSFHTA GMYEAMNDVY KILIPIAEEA RDYKKLANIH GKLQEAFNKI
EQLQGKRVFG TYFRVGFYGS KFGDLDGEEF IYKEPTLTKL PEIFNRLENF YGERFGMDNM
VIIKDSNMVD PKSLDPDKGY IQITYVEPYF DTFEVPRHRA TYFHKNFNIK RFVYYTPFTV
SGRAHGELQE QCKRRTVLTT ANHFPYIKTR IQVVERRQSV VTPIEGAIED IQKKTTELAA
ATHQEPPDPK ILQMVLQGCI GTTVNQGPME VALVFLSDLQ EGKIPNRLQT KLRLCFKDFS
KKCSDALRKN KNLIGPDQRD YQKELERNYH KFTDRLTPLL GRTI
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