ID E0W245_PEDHC Unreviewed; 490 AA.
AC E0W245;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=8232531 {ECO:0000313|EnsemblMetazoa:PHUM584050-PA};
GN ORFNames=Phum_PHUM584050 {ECO:0000313|EMBL:EEB19701.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB19701.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19701.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB19701.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19701.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM584050-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM584050-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; AAZO01007120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235874; EEB19701.1; -; Genomic_DNA.
DR RefSeq; XP_002432439.1; XM_002432394.1.
DR AlphaFoldDB; E0W245; -.
DR STRING; 121224.E0W245; -.
DR EnsemblMetazoa; PHUM584050-RA; PHUM584050-PA; PHUM584050.
DR GeneID; 8232531; -.
DR KEGG; phu:Phum_PHUM584050; -.
DR CTD; 8232531; -.
DR VEuPathDB; VectorBase:PHUM584050; -.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_018084_6_1_1; -.
DR InParanoid; E0W245; -.
DR OMA; IPRDGFN; -.
DR OrthoDB; 916229at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF28; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 7.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..34
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REGION 471..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 54361 MW; 90B79084DDC316E3 CRC64;
MRRRRNEVTI ELRKNKREET LQKRRNIFDI ESLEEDDIDK KISVEEIVRN SASSNPEIQL
NAVQAARKLL SSDRNPPIDD LINAGILPIL VNCLCSENPT LQFEATWALT NIASGSSRQT
KAVVDAQAVP LFLQLLLSPH QNVCEQAVWA LGNVIGDGPD LRDYVINLGV VGPLLTFIKP
NIPISFLRNI TWVIVNLCRS KDPPPPSQTI SEILPALNVL IHHSDINILV DTVWAISYLT
DGGNDQIQMV VDSGIVSKLI PLLSHKEVKV QTAALRAVGN IVTGTDEQTQ VVLNCDALSH
FPELLSHSKE KICKEAVWFL SNITAGNQHQ VQQVIDANLL PHIIRNLVEG EFQTKKEAAW
ALSNLTLSGN RDQVATLIQE GVIPPFCDLL ACNDNQVIQV VLDGINNMLR MAGPQVEGLA
NMIEECGGLD KIEALQNHEN HDIYKLAFDI IENYFSEDAE DDPNLMPQAT ETGFQFDPNT
SISSEGFKFE
//
