ID E0W2J6_PEDHC Unreviewed; 536 AA.
AC E0W2J6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Putative glycerol kinase 5 {ECO:0000256|ARBA:ARBA00013787};
DE EC=2.7.1.30 {ECO:0000256|ARBA:ARBA00012099};
DE AltName: Full=ATP:glycerol 3-phosphotransferase 5 {ECO:0000256|ARBA:ARBA00033026};
GN Name=8232826 {ECO:0000313|EnsemblMetazoa:PHUM594290-PA};
GN ORFNames=Phum_PHUM594290 {ECO:0000313|EMBL:EEB19852.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB19852.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19852.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB19852.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB19852.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM594290-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM594290-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate;
CC Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC EC=2.7.1.30; Evidence={ECO:0000256|ARBA:ARBA00001373};
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005190}.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC {ECO:0000256|ARBA:ARBA00009156, ECO:0000256|RuleBase:RU003733}.
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DR EMBL; AAZO01007239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235878; EEB19852.1; -; Genomic_DNA.
DR RefSeq; XP_002432590.1; XM_002432545.1.
DR AlphaFoldDB; E0W2J6; -.
DR STRING; 121224.E0W2J6; -.
DR EnsemblMetazoa; PHUM594290-RA; PHUM594290-PA; PHUM594290.
DR GeneID; 8232826; -.
DR KEGG; phu:Phum_PHUM594290; -.
DR CTD; 8232826; -.
DR VEuPathDB; VectorBase:PHUM594290; -.
DR eggNOG; KOG2517; Eukaryota.
DR HOGENOM; CLU_009281_2_3_1; -.
DR InParanoid; E0W2J6; -.
DR OMA; CTFLTWN; -.
DR OrthoDB; 2734344at2759; -.
DR UniPathway; UPA00618; UER00672.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07793; FGGY_GK5_metazoa; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR InterPro; IPR037444; GK5_FGGY.
DR PANTHER; PTHR10196:SF68; GLYCEROL KINASE 5-RELATED; 1.
DR PANTHER; PTHR10196; SUGAR KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|RuleBase:RU003733, ECO:0000313|EMBL:EEB19852.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transferase {ECO:0000256|RuleBase:RU003733, ECO:0000313|EMBL:EEB19852.1}.
FT DOMAIN 27..287
FT /note="Carbohydrate kinase FGGY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00370"
FT DOMAIN 297..484
FT /note="Carbohydrate kinase FGGY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02782"
SQ SEQUENCE 536 AA; 59794 MW; A68251D685ADC373 CRC64;
MSPGAENTTR EDRLIFFKEM TEDKFVAALD VGTTTLRCCI FNQKAQLCGS GIDQIELLYP
EPGFVEIDPD KLWISVQRVI KLSLQDAGLT SNQITSLGLS VQRSSFTTWN KKTGTPYHNI
IIWKDLRANK IVKELNKSFL MKGMRATSKI LYAFTRRKRF LAGSQMKVMN TQVTARLLWV
LENIPSLKKS IEKNEVHFGT LDTWLIYKLT GGEQHVTDVS NAACTGFFDP FTMDWADWAF
YIFGLPRTIL PKILDTAGNF GYTSSYLFGS PIPIRSCVAD QSASLFGSCG FKRGDFKITL
GTGSFVNINT GSEPHASITG LYPIVGWRIN KETIYMAEGA SNDTGTTIKW AQKIGIIKDP
SESNDIANSV NDANGVCFIP SFSGIQAPVN DGLAAAGFIG LKPTTSKGHM MRAILESIVF
RIHQLFEVVK KEIGLDFKLI RIDGGVSNNN FITQLIADLT QIPIERPSST EISVLGAAYL
AGLASGVWNS KEEISRLRTV DQIFIPRPNI REEYKEQIEL WKSAISRFLN WYPDEY
//
