ID E0W3P1_PEDHC Unreviewed; 1601 AA.
AC E0W3P1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Myosin-18A, putative {ECO:0000313|EMBL:EEB20247.1, ECO:0000313|EnsemblMetazoa:PHUM607810-PA};
GN Name=8237126 {ECO:0000313|EnsemblMetazoa:PHUM607810-PA};
GN ORFNames=Phum_PHUM607810 {ECO:0000313|EMBL:EEB20247.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB20247.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB20247.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB20247.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB20247.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM607810-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM607810-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AAZO01007430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235882; EEB20247.1; -; Genomic_DNA.
DR RefSeq; XP_002432985.1; XM_002432940.1.
DR STRING; 121224.E0W3P1; -.
DR EnsemblMetazoa; PHUM607810-RA; PHUM607810-PA; PHUM607810.
DR GeneID; 8237126; -.
DR KEGG; phu:Phum_PHUM607810; -.
DR CTD; 8237126; -.
DR VEuPathDB; VectorBase:PHUM607810; -.
DR eggNOG; KOG0161; Eukaryota.
DR HOGENOM; CLU_000192_4_3_1; -.
DR InParanoid; E0W3P1; -.
DR OMA; KRPTITW; -.
DR OrthoDB; 3687088at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0030017; C:sarcomere; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01386; MYSc_Myo18; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF36; MYOSIN HEAVY CHAIN-LIKE, ISOFORM B; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT DOMAIN 82..813
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1568..1601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 881..974
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 999..1125
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1167..1555
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 175..182
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1601 AA; 182197 MW; 834587C4E7B53319 CRC64;
MKIALLFLTA KTEEDLANER AWLDTEKLWL VHRGGFTPVK ILSNSSNQST DTGKVKIKID
NTNEILEVDE DDLEKANPSQ LDKIEDVCHL RYINESSVLY ILRQRFGNNL IHTYAAGNLL
VINPQCTLSI YNEKVAALFR GCKSEDMPPH IYAMAQSSYR SMLSSRKDQS IVLLGRSGSG
KTHNFRHILN YLLHSAGSVN KVLNVEKLNA LHTILEAFGN ARTCLSINAT RCTNLITLDF
DQTGQIASVC VQMLMLEKQR VAKRPNGEGI FNVFYWLLAG AESSLAKKLL LDTNASQNSN
LFMTSIYKNE DRQRAVMELN KLTLAMNTLG INEKECFVIW SVLAAIYHLG NAGAVRVGTN
KWQFADPTHS SRACRLLGTT SEELCQVLWN NPLSPARAPS SPSDKDKLIA GVDALEGFVI
GLYSEIVSVV NTLINRSLTT NIHSTMSLIV VDSPGFQNPG SCGQQSGATF SDLCHNYVQE
RLHLLYHNFN IIAPRDRYVQ EHIDVNTDEI YSEVNSPSQL ISMLDKSSPT GVLKTSQTDL
REVDRRGLLW LLEEESLYPN STDETFLERL FMHHGEKDHQ LLLRKSGPGH FVIHHLQGTN
PVTYNVNGFV KAAKENPLTR SANGFLQEST KEDISEVFVK GKNGLLSSGV EGSQSLRRMS
SIRRTCSVAV KRKSISLQVK FTADGLIETL RRTRPRFVFC LLPQHNAGNT EIIPGSASTG
ENILNVPLLR SQIRGCEILP VVRIFKLGFP EYFPHGEFKR RFRLLAPGCG GSSGHAVEEM
LMLMDVDVTS YRIGVTQVFF RAGVLAQLES QRDEKLADLI IRFQSRCRGY IARKKLAKLK
IQDLAVRCIQ RNVRKLMQVR EWPWWRLYVK VTPILNVHRT EEELTAKVQE LETVKSLLEK
VESERNQLKL ENDKLETKLS EMTMDLSEER TAGALQAERL EAETAERVRL EQELSQIQNE
KKNLQQASER LEMELFYARA DVNGLSESEG DLEDGGGDAA LYKNKCERTM RELEFTRRRL
QQQHEDDLEQ LVGLKKQLEK KLADAYEEVE EQRQVAGQWK RKVQKLQSEM NDLRLLLEEQ
SSRNNLLEKK QRKFDSEIQL LQEELRSEKN QKERLSREKE MAYAEKYSME QNLSSFRLEL
ELKDEKLLSL TQELEEFSRG GGSEQEITQL RKAKHDLEIK LKEQEEELDE LAGQVSMLEG
NKLRLEMSLE SLRKEHRREI AQRDDELDES RSNTQKKIKV LEAQLESEHE ERTLLVREKH
ELERRLADAE ERGRHNKAAD EDALLRARRD LKKTKALLRD AQIMLERAKQ DSPSKAALRA
LKNQLEDVEL ARASAVKAKQ SLDSELNEVN GLLEEAIRAK GDAENRCQAA LRETNALRMQ
VEENEEELAE LLKKYRQIVQ QLSAEQLANQ ETAGALAEAE VERASLKEQL AELSARLEAN
AVLDPLSGLA QKKLEIRIKE LESRLDLEQT TRGRLEVQIT RLKENVERLN EDCIQARTKE
QGATDTARKL QRTLRETKEE LAKHQAKEQE ALHKRKELEK RLETAEQEAF TARTDLRLAV
KRIEDLQSAI SGEIGSDSER SESDEDDSGD DSLISHVAST K
//
