ID E0W441_PEDHC Unreviewed; 521 AA.
AC E0W441;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Ceramide kinase, putative {ECO:0000313|EMBL:EEB20397.1, ECO:0000313|EnsemblMetazoa:PHUM614990-PA};
DE EC=2.7.1.138 {ECO:0000313|EMBL:EEB20397.1};
GN Name=8239796 {ECO:0000313|EnsemblMetazoa:PHUM614990-PA};
GN ORFNames=Phum_PHUM614990 {ECO:0000313|EMBL:EEB20397.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB20397.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB20397.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB20397.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB20397.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM614990-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM614990-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAZO01007518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235886; EEB20397.1; -; Genomic_DNA.
DR RefSeq; XP_002433135.1; XM_002433090.1.
DR AlphaFoldDB; E0W441; -.
DR STRING; 121224.E0W441; -.
DR EnsemblMetazoa; PHUM614990-RA; PHUM614990-PA; PHUM614990.
DR GeneID; 8239796; -.
DR KEGG; phu:Phum_PHUM614990; -.
DR CTD; 8239796; -.
DR VEuPathDB; VectorBase:PHUM614990; -.
DR eggNOG; KOG1115; Eukaryota.
DR HOGENOM; CLU_013399_2_2_1; -.
DR InParanoid; E0W441; -.
DR OMA; WDTHPLS; -.
DR OrthoDB; 7645at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0001729; F:ceramide kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0102773; F:dihydroceramide kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR045363; CERK_C.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF6; CERAMIDE KINASE, ISOFORM A; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF19280; CERK_C; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EEB20397.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transferase {ECO:0000313|EMBL:EEB20397.1}.
FT DOMAIN 84..234
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 521 AA; 58656 MW; 51A5D27E0A011660 CRC64;
MISLKRWLTL KKKKSGSDTG HFNSSAFPDL PESPDYFHTS LIIHFVKHVS NNKWRLWSVT
FHHTDGKEVS CWYNALESAL NREDRPKNFL VFINPFCGKQ KGVEIYNKTV KPILELAKVD
ATVIVTEHNM HCRDVILSKD IKKFDGVMAV GGDGTISEII NSLIIRMIRD ENQNENEWNL
DIPKVKIPVA IIPCGSTDCI AYSLNGTQDR KTAAIFAVSG FRCGLDVCSV YSQKGLCRYF
LGLLAYGFLG DVLKKSEKHR WMGPKRYDYA GFLTALKNKK YYCEINMVLS HRAPGIGPKC
YSGCEICEQT NRGGKMVVDS KSRYQEKNLS AIRNDLKINF NGECKGNVEK TVTVRGKYFV
VGCANVSCAC ERSPNGFSPY SHVGDGSMDV LLIKPQSLFD IGRILLRSKS KTQALSDLSF
IDTYKAKEMN LKVLDKNMEV VTSAKDGERY VGASVWNCDG ELVFDSNIKV KNNSQLIQVF
TRRISPNPSK NSSWCWNCYN CSKSNSKDLD KRTTTNIIIA T
//
