ID E1B7G1_BOVIN Unreviewed; 454 AA.
AC E1B7G1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Zinc finger protein 514 {ECO:0000313|Ensembl:ENSBTAP00000048955.3};
GN Name=ZNF514 {ECO:0000313|Ensembl:ENSBTAP00000048955.3,
GN ECO:0000313|VGNC:VGNC:37293};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000048955.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000048955.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048955.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000048955.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048955.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001103561.2; NM_001110091.1.
DR AlphaFoldDB; E1B7G1; -.
DR SMR; E1B7G1; -.
DR STRING; 9913.ENSBTAP00000048955; -.
DR PaxDb; 9913-ENSBTAP00000048955; -.
DR Ensembl; ENSBTAT00000053384.3; ENSBTAP00000048955.3; ENSBTAG00000001947.6.
DR GeneID; 782049; -.
DR KEGG; bta:782049; -.
DR CTD; 84874; -.
DR VEuPathDB; HostDB:ENSBTAG00000001947; -.
DR VGNC; VGNC:37293; ZNF514.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163499; -.
DR InParanoid; E1B7G1; -.
DR OMA; STDWEKR; -.
DR TreeFam; TF337055; -.
DR Reactome; R-BTA-212436; Generic Transcription Pathway.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000001947; Expressed in semen and 89 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF148; ZINC FINGER IMPRINTED 2; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 39..110
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 242..269
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 270..297
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 298..325
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 326..353
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 354..381
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 382..409
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 410..437
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 52246 MW; 472DA493C1DA065B CRC64;
MDSRVSVLPS QDPALPPERG LGEKGTASLF LKARPQDLMT FEDVAVEFTW WEWGQLDPTQ
KDLYWEVMLE NFKNLASLGF PVSKPYMICQ LEEGEEPCIL EREISTGVHS DWERRPQAKK
PMLSQGLSKE ELFQRASVEK HIRDEFRSSK LKATCGWDDQ VEIYPKKQER HLKETSLTQK
SPPTPKRGHE SSESGTSSGL RSVPINQHHV PTGEGYYNCD TEFRQISGRS DSRRTQPGKK
SCKCNECGKL FHFQSELQRH QRRHTGEKPY ECGECGRAFG HISSLIKHQR THTGEKPYEC
SECRRAFSQS SSLVLHYRFH TGEKPYKCNE CGRAFGHTSS LIKHQRTHTG EKPYECRECG
RTFSQSSSLI VHYRFHTGEK PYKCNRCGRA FSQSSSLTQH YRHHTGEKPY KCNECGRAFA
HTASLIKHQK SHAGKKTLRI QPMQEGFQLE NTHH
//
