ID E1BAR8_BOVIN Unreviewed; 496 AA.
AC E1BAR8;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=DMRT like family A1 {ECO:0000313|Ensembl:ENSBTAP00000001736.5};
GN Name=DMRTA1 {ECO:0000313|Ensembl:ENSBTAP00000001736.5,
GN ECO:0000313|VGNC:VGNC:28113};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000001736.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000001736.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001736.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000001736.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001736.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00070}.
CC -!- SIMILARITY: Belongs to the DMRT family.
CC {ECO:0000256|ARBA:ARBA00006834}.
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DR RefSeq; NP_001179569.1; NM_001192640.1.
DR AlphaFoldDB; E1BAR8; -.
DR SMR; E1BAR8; -.
DR STRING; 9913.ENSBTAP00000001736; -.
DR PaxDb; 9913-ENSBTAP00000001736; -.
DR Ensembl; ENSBTAT00000001735.6; ENSBTAP00000001736.5; ENSBTAG00000001315.6.
DR GeneID; 527219; -.
DR KEGG; bta:527219; -.
DR CTD; 63951; -.
DR VEuPathDB; HostDB:ENSBTAG00000001315; -.
DR VGNC; VGNC:28113; DMRTA1.
DR eggNOG; KOG3815; Eukaryota.
DR GeneTree; ENSGT00940000160640; -.
DR HOGENOM; CLU_038477_1_0_1; -.
DR InParanoid; E1BAR8; -.
DR OMA; ELQFMYT; -.
DR OrthoDB; 5401440at2759; -.
DR TreeFam; TF317837; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000001315; Expressed in saliva-secreting gland and 26 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0060179; P:male mating behavior; IEA:Ensembl.
DR GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR CDD; cd14417; CUE_DMA_DMRTA1; 1.
DR Gene3D; 4.10.1040.10; DM DNA-binding domain; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR005173; DMA.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR046472; DMRT5_1_DMB_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12322; DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT; 1.
DR PANTHER; PTHR12322:SF71; DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A1; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF03474; DMA; 1.
DR Pfam; PF20624; DMRT5_DMB; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; Cysteine-rich DNA binding domain, (DM domain); 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00070}; Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00070}.
FT DOMAIN 89..136
FT /note="DM"
FT /evidence="ECO:0000259|PROSITE:PS50809"
FT DNA_BIND 89..136
FT /note="DM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00070"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..38
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 52749 MW; F797E1C3FA42764B CRC64;
MEQSQCGSRD RSRSGPLHLA PGLVVAAPPP PSPALPVPPG IPVPPTFLRP SSLFLRAASS
AGSGGCPPPA ELERGVGAVA GGYPRTPKCA RCRNHGVVSA LKGHKRFCRW RDCACAKCTL
IAERQRVMAA QVALRRQQAQ EESEARGLQR LLYPGPSGPG GRSSGGSSRT ETSQTTSSGP
ATVTALGLSA SRQASGLATP VFEIFQPDYI EEKQGQKESK CDSCQSGQEE LGSKSHQFTL
RSSPKSNDVT GKQNIRSSIS ENPNKDDSIQ SLHPGEQSGG EESPRSLSSS DLESGNESEW
AKDFTDSTAS HPTVSSRPRD PLDILTKIFP SYRRSRLEGI LQFCKGDVVQ AIEEILNGKE
HKPDTRDLAN SGALENTAFP RVSNFSLAGI GFGTLGNKSA FSPLHTSSAS YGGDSSLYSL
NPRLGISPFR LAYSSPGRGL SGFMSPYLTP GLVPSLPCRP ALDYAFSGMI RDSSYLPIKD
SVTGGRLYSR PNQSNL
//
