ID E1BAV2_BOVIN Unreviewed; 1057 AA.
AC E1BAV2;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase 4 {ECO:0000313|Ensembl:ENSBTAP00000018639.5};
GN Name=HERC4 {ECO:0000313|Ensembl:ENSBTAP00000018639.5,
GN ECO:0000313|VGNC:VGNC:55988};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000018639.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000018639.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018639.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000018639.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018639.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001070362.2; NM_001076894.2.
DR AlphaFoldDB; E1BAV2; -.
DR SMR; E1BAV2; -.
DR STRING; 9913.ENSBTAP00000018639; -.
DR PaxDb; 9913-ENSBTAP00000018639; -.
DR Ensembl; ENSBTAT00000018639.6; ENSBTAP00000018639.5; ENSBTAG00000014029.6.
DR GeneID; 533336; -.
DR KEGG; bta:533336; -.
DR CTD; 26091; -.
DR VEuPathDB; HostDB:ENSBTAG00000014029; -.
DR VGNC; VGNC:55988; HERC4.
DR eggNOG; KOG0941; Eukaryota.
DR GeneTree; ENSGT00940000158924; -.
DR HOGENOM; CLU_002173_5_3_1; -.
DR InParanoid; E1BAV2; -.
DR OMA; FKSQACW; -.
DR OrthoDB; 5475808at2759; -.
DR TreeFam; TF315189; -.
DR Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000009136; Chromosome 28.
DR Bgee; ENSBTAG00000014029; Expressed in esophagus and 108 other cell types or tissues.
DR ExpressionAtlas; E1BAV2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF5; E3 UBIQUITIN-PROTEIN LIGASE HERC4-RELATED; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 7.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 1..52
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 53..102
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 103..155
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 156..208
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 209..260
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 261..312
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 314..380
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 730..1057
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 1025
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1057 AA; 118589 MW; 01DA14F0209DE6EE CRC64;
MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKKVRDVG CGLRHTVFVL DDGTVYTCGC
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLLG
SEECIRVPRN IKSLSDIQIV QVACGYYHSL ALSKASEVFC WGQNKYGQLG LGIDCKKQAS
PQLIKSLLGI PFMQIAAGGA HSFVLTLSGA IFGWGRNKFG QLGLNDENDR YVPNLLKSLR
TQKIVYICCG EDHTAALTKE GGVFTFGAGG YGQLGHNSTS HEINPRKVFE LMGSIVTQIA
CGRQHTSAFV PSSGRIYSFG LGGNGQLGTG STSNRKSPFT VKGNWFPYNG QCPPDFDSEE
YFCVKRIFSG GDQSFSHYSN PQNCGPPDDF RYPDPSKQIW TVNEALIQKW LSYPSGRFPV
EIANEIDGTF SSSGCLNGSF LAVSNDDHYR TGTRFSGVDM NAARLLFHKL IQPDHPQIAQ
QVAASLEKNL IPKLTSSLPD VEALRFYLTL PECPLMSDSN NFTTIAIPFG TALVNLEKAP
LKVLENWWSV LEPPLFLKIV ELFKEVVVHL LKLYKIGIPP SERRIFNSFL HTALKVLEIL
HRVNEKSGQI IQYDKFYIHE VQELIDIRND YIIWVQQQAY GMDVNHGLTE LADIPVTICT
YPFVFDAQAK TTLLQTDAVL QMQMAIDQAH RQNVSSLFLP VIESVNPCLI LVVRRENIVG
DAMEVLRKTK NIDYKKPLKV IFVGEDAVDA GGVRKEFFLL IMRELLDPKY GMFRYYEDSR
LIWFSDKTFE DSDLFHLIGV ICGLAIYNFT IVDLHFPLAL YKKLLKKKPS LEDLKELVPD
VGRSMQQLLD YPEDDVEETF CLNFTITVEN FGATEVKELV LNGADTAVNK QNRQEFVDAY
VDYIFNKSVA SLFDAFHAGF HKVCGGKVLQ LFQPNELQAM VIGNTNYDWK ELEKNTEYKG
EYWAEHPTIK MFWEVFHELP LEKKKQFLLF LTGSDRIPIL GMKSLILVIQ STGGGEEYLP
VSHTCFNLLD LPKYTDKETL RSKLIQAIDH NEGFSLI
//