ID E1BB28_BOVIN Unreviewed; 919 AA.
AC E1BB28;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Sarcosine dehydrogenase {ECO:0000313|Ensembl:ENSBTAP00000005925.4};
GN Name=SARDH {ECO:0000313|Ensembl:ENSBTAP00000005925.4,
GN ECO:0000313|VGNC:VGNC:34289};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005925.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000005925.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005925.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000005925.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005925.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR RefSeq; NP_001179970.1; NM_001193041.1.
DR RefSeq; XP_005213422.1; XM_005213365.3.
DR AlphaFoldDB; E1BB28; -.
DR SMR; E1BB28; -.
DR PaxDb; 9913-ENSBTAP00000005925; -.
DR Ensembl; ENSBTAT00000005925.5; ENSBTAP00000005925.4; ENSBTAG00000004510.5.
DR GeneID; 614603; -.
DR KEGG; bta:614603; -.
DR CTD; 1757; -.
DR VEuPathDB; HostDB:ENSBTAG00000004510; -.
DR VGNC; VGNC:34289; SARDH.
DR eggNOG; KOG2844; Eukaryota.
DR GeneTree; ENSGT00940000157589; -.
DR HOGENOM; CLU_007884_11_4_1; -.
DR OMA; PMKHAYI; -.
DR OrthoDB; 1815533at2759; -.
DR TreeFam; TF314735; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000004510; Expressed in cortex of kidney and 94 other cell types or tissues.
DR ExpressionAtlas; E1BB28; baseline and differential.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR13847:SF200; SARCOSINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 70..428
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 431..486
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 489..798
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 824..909
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 100782 MW; FD2F692E65119F10 CRC64;
MASLSRALRG IAATRPRQSP ARGWGLRPLV SGPGPTSEKS VPYQRTLKEA EDASAAAQGP
SQPLPGTASV VVIGGGSLGC QTLYHLAKLG VSGAVLLERE RLTSGTTWHT AGLLWQLRPS
DVEVELLAHT RQVVSRELEE ETGLHTGWIQ NGGLFIASSQ QRLDEYKRLM SLGRVYGIES
HVLSPGETKA LYPLMNVEDL YGTLYVPHDG TMDPAGTCTS LARAATTRGA QIIENCPVTG
IRVRTDDFGV RRVAAVETEH GSIRTPCVIN CAGVWARAVG RMAGVNVPLV AMHHAYVVTE
RIEGIQNMPN VRDHDASVYL RLQGDALSVG GYETNPIFCE EVSDEFAFGL FDLDWDVFTQ
HIEGAINRVP VLEKTGIKST VCGPESFTPD HKPLMGEAPE LRGFFLGCGF NSAGMMLGGG
CGQQLAYWIV HGRPEKDMHS YDIRRFHRSL TGHGRWIRER SHEAYAKNYS VVFPHDEPLA
GRNMRTGPLH EELRARGCVF QERHGWERPG WFSAQGPAPV LPYDYCGAYG HRAREDYAYG
RLLGQEYTFS FPPHHDVIKK ECLACRGAAA VFDMSYFGKF FLVGPDARKA ADWLFSADVS
RPPGSTVYTC MLNHRGGTES DLTVSRLAPG PQASPLAPAF EGDGYYLAVG GAAAQHNWSH
IRTVLQDRKF RCQLIDSSED LGLISVQGPA SRAVLQELLE ADLSDDAFPF STHKLVRAAG
HLVRAVRLSF VGELGWELHA PRPSCLPVYQ ALMTAGAKHG LVNAGYRAID SLSIEKGYRH
WHADLRADDS PLEAGLAFTC KLKSSVPFLG REALEKQRAE GLRRRLVGFT VDEKVSMFGL
EAIWRNGQVV GHVRRADFGF TINKTLAYGY IRDPSGGPVS LDFVKSGDYA LERMGVTHAA
QAHLKSPFDP DNKRVKGVY
//
