ID E1BB46_BOVIN Unreviewed; 963 AA.
AC E1BB46;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=SH3 domain binding protein 4 {ECO:0000313|Ensembl:ENSBTAP00000018420.5};
GN Name=SH3BP4 {ECO:0000313|Ensembl:ENSBTAP00000018420.5,
GN ECO:0000313|VGNC:VGNC:34567};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000018420.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000018420.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018420.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000018420.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000018420.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC {ECO:0000256|ARBA:ARBA00004132}. Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004600}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
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DR RefSeq; NP_001137560.1; NM_001144088.1.
DR RefSeq; XP_005205011.1; XM_005204954.3.
DR RefSeq; XP_005205012.1; XM_005204955.3.
DR RefSeq; XP_005205013.1; XM_005204956.3.
DR RefSeq; XP_005205016.1; XM_005204959.3.
DR RefSeq; XP_010802146.1; XM_010803844.2.
DR RefSeq; XP_015322602.1; XM_015467116.1.
DR RefSeq; XP_015322605.1; XM_015467119.1.
DR STRING; 9913.ENSBTAP00000018420; -.
DR PaxDb; 9913-ENSBTAP00000018420; -.
DR Ensembl; ENSBTAT00000018420.6; ENSBTAP00000018420.5; ENSBTAG00000013869.6.
DR Ensembl; ENSBTAT00000071939.1; ENSBTAP00000073924.1; ENSBTAG00000013869.6.
DR Ensembl; ENSBTAT00000082855.1; ENSBTAP00000070962.1; ENSBTAG00000013869.6.
DR Ensembl; ENSBTAT00000087052.1; ENSBTAP00000071811.1; ENSBTAG00000013869.6.
DR GeneID; 520462; -.
DR KEGG; bta:520462; -.
DR CTD; 23677; -.
DR VEuPathDB; HostDB:ENSBTAG00000013869; -.
DR VGNC; VGNC:34567; SH3BP4.
DR eggNOG; ENOG502QTUW; Eukaryota.
DR GeneTree; ENSGT00390000013151; -.
DR HOGENOM; CLU_013080_2_0_1; -.
DR OMA; RQNKSHY; -.
DR OrthoDB; 4019548at2759; -.
DR TreeFam; TF105572; -.
DR Reactome; R-BTA-9639288; Amino acids regulate mTORC1.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000013869; Expressed in saliva-secreting gland and 103 other cell types or tissues.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:0061462; P:protein localization to lysosome; IEA:Ensembl.
DR CDD; cd11757; SH3_SH3BP4; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035456; SH3BP4_SH3.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR15603:SF3; SH3 DOMAIN-BINDING PROTEIN 4; 1.
DR PANTHER; PTHR15603; SH3 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 55..114
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 317..454
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 654..724
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 963 AA; 107096 MW; B9E434DE34926EEA CRC64;
MAAQRIRAAN SSGLPRCKSE GTLIDLSEGF SESSFNDVKV PSPSALLVDN PTPFGNAKEV
IAIKDYCPTN FTTLKFSKGD HLYVLDTSGG EWWYAHNTTE MGYIPSSYVQ PLNYRNSTLS
DSGMIDNLPD SPDEVAKELD LLGGWTDAKK ESSKPYSNNP FWNGVQTNPF LNGNVPAMPS
VDELMPRSAV DLLLFDTGTS SFTESSSATT NSTGNIFDEL PAAGRLPTEP PVKRDNPFFR
SKRSYSLSEL SVLQAKSDAP ASSGFFTGLK SPAPEQFQSR EDFRAAWLSH RKLARSCHDL
DLLGQSPGWG QTQAVETNIV CKLDSSGGAV QLPDANISIH VPEGHVAPGE MQQISMKALL
DPPLELNSDR CSSISPVLEV KLSTLEVKTH LILEMKVSAE VKSDIFSKST VGLQCLRSDS
KEGPYVPIPL AYSYGDTVQV QLDNLEPCMY LAIVAHGPNI LYPSTVWDFI NKKVTVGLYG
PKHIHPSFKT VVTIFGHDCA PKTLLVSEVT RQAPTPAPVA LQLWGKHQFV LSRPQDLQVC
VFSNMTNYEV KASEQAKAVR GFQVKLGKVS RLIFPITCQN PSELSDFTLR VQVKDDQEAI
LTQFCVQTPQ PPPKSAIKPS GQRRFLKKNE VGKIILSPLA ATTKYPTFQD RPVSSLKFGK
LLKTVVRQSK NHYLLEYKKG DAIALLSEEK IRLKGQLWTK EWYIGYHQGR VGLVHAKNVL
VVGKARPSLL AGPELSTSVL LEQILRPCKF LTYIYASVRT LLMENVSSWR SFADALGYGD
LPLTFFCRAE LDSEPERVAS VLEKLKEDCN NTDNKDRKSF QKELMMALLK MDCQGLVVRL
IQDFVLLTTA VEVAQRWREL AEKLAKVSKQ QMDAYESPHR DRNGVVDSEA MWKPAYDFLL
TWSHQIGDSY RDVIQELHIG LDKMKNPITK RWKHLTGTLI LVNSLDILRA SAFSPVDHDD
FVI
//
