ID E1BB66_BOVIN Unreviewed; 524 AA.
AC E1BB66;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN Name=SLC22A20 {ECO:0000313|Ensembl:ENSBTAP00000013515.6};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000013515.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000013515.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013515.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000013515.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013515.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; E1BB66; -.
DR STRING; 9913.ENSBTAP00000013515; -.
DR PaxDb; 9913-ENSBTAP00000013515; -.
DR Ensembl; ENSBTAT00000013515.6; ENSBTAP00000013515.6; ENSBTAG00000010233.6.
DR VEuPathDB; HostDB:ENSBTAG00000010233; -.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000162438; -.
DR HOGENOM; CLU_001265_33_3_1; -.
DR InParanoid; E1BB66; -.
DR OMA; PEPCQRF; -.
DR TreeFam; TF315847; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000010233; Expressed in olfactory segment of nasal mucosa and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR24064; SOLUTE CARRIER FAMILY 22 MEMBER; 1.
DR PANTHER; PTHR24064:SF34; SOLUTE CARRIER FAMILY 22 MEMBER 20; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..511
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 524 AA; 57027 MW; 2FFD70676D5A9C97 CRC64;
MAFTDLLDAL GGVGRFQLVS TALLLLPCSL LACHNFLQNF TAAVPPHHCQ SPANHSAAAV
YGSGAWLRAT VPLHPLGLPE PCRRFTRPQW ALLSPNASVD GAATEGCKDG WVYDRSVFPS
TIVTEWDLVC EARTLRDLAQ SAYMAGVLAG AAVFGSLADR LGRKAPLVWS YLQLAVSGAA
TAYFSSFGTY CFCRFLMGMT FSGIILNSLS LVVEWMPTRG RTVAGILLGY SFTSGQLILA
GVAYLIRPWR WLQFAVSVPF LIFFLYSWWL PESSRWLLLH GKTQVALKNL RKVAAMNGRK
EEGERLTKEV VSSYIQSEFA AGRPSNSVLD LFRTPAIRKV TCCLMVVWFS NSLAYYGLAM
DLQKFGLSVY LVQVLFGVID IPAMLVATTT MIYVGRRATV ASFLILAGLM VISNMFVPED
MQSLRTAQAA LGKGCLASSF ICVYLFTGEL YPTEIRQMGM GFASVNARLG GLAAPLLTML
GEFSAVLPPV GFGAPSILAG LAVCFLAETR DVPLVETIEA MERR
//
