ID E1BBH4_BOVIN Unreviewed; 605 AA.
AC E1BBH4;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Unc-93 homolog B1, TLR signaling regulator {ECO:0000313|Ensembl:ENSBTAP00000001581.5};
GN Name=UNC93B1 {ECO:0000313|Ensembl:ENSBTAP00000001581.5,
GN ECO:0000313|VGNC:VGNC:49587};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000001581.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000001581.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001581.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000001581.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001581.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001180076.1; NM_001193147.1.
DR AlphaFoldDB; E1BBH4; -.
DR STRING; 9913.ENSBTAP00000001581; -.
DR PaxDb; 9913-ENSBTAP00000001581; -.
DR Ensembl; ENSBTAT00000001581.5; ENSBTAP00000001581.5; ENSBTAG00000001193.5.
DR GeneID; 508878; -.
DR KEGG; bta:508878; -.
DR CTD; 81622; -.
DR VEuPathDB; HostDB:ENSBTAG00000001193; -.
DR VGNC; VGNC:49587; UNC93B1.
DR eggNOG; KOG3097; Eukaryota.
DR GeneTree; ENSGT00530000063359; -.
DR HOGENOM; CLU_037591_1_0_1; -.
DR InParanoid; E1BBH4; -.
DR OMA; FWAPKPR; -.
DR TreeFam; TF314905; -.
DR Reactome; R-BTA-1679131; Trafficking and processing of endosomal TLR.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000001193; Expressed in monocyte and 104 other cell types or tissues.
DR GO; GO:0032009; C:early phagosome; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035325; F:Toll-like receptor binding; IBA:GO_Central.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:Ensembl.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0002457; P:T cell antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0034138; P:toll-like receptor 3 signaling pathway; IBA:GO_Central.
DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IBA:GO_Central.
DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; IBA:GO_Central.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:Ensembl.
DR CDD; cd17408; MFS_unc93B1; 1.
DR InterPro; IPR043268; UNC93B1.
DR PANTHER; PTHR46744; PROTEIN UNC-93 HOMOLOG B1; 1.
DR PANTHER; PTHR46744:SF1; PROTEIN UNC-93 HOMOLOG B1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 60..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 67927 MW; B3A63E7EDDFD7C35 CRC64;
MEAEPPLYPV AGAAGPQGDE DRLGVPDGPE APLDELVGAY PNYNEEEEER RYYRRKRLGV
LKNVLAASAG GMLTYGVYLG LLQMQLILHY DETYREVKYG NMGLPDIDSK MLMGINVTPI
AALLYTPVLI RFFGTKWMMF LAVGIYALFV STNYWERYYT LVPSAVALGM AIVPLWASMG
NYITRMAQKY YEYSHYKEQD EQGPQQRPPR GSHAPYLLVF QAIFYSFFHL SFACAQLPMI
YFLNHYLYDL NHTLFNVQNC GTNSQGILLG FNKTVLRTLP RSRNLIVVES VLMAVAFLAM
LLVLGLCGAA YRPTEEIDLR SVGWGNIFQL PFKHVRDFRL RHLVPFFIYS GFEVLFACTG
LALGYGVCSV GLERLAYLLV AYSLGASASS ALGLLGLWLP RPVPLVAGAG LHLLLTLSLF
FWAPKPRTLQ HIWILYTVAV LWGVGSALNK TGISTLLGIL YEDKERQDFI FTIYHWWQAV
AIFTVYLGSS LPMKAKLTVL LVTLVASAAS YLWMEQKLRR GVVPRQPRIP RPQHKVRGYR
YLEEDNSDES EAEGERSGCG GGGRGDCAEE EVPPAWPRPG PEPAILYRRP CPYEQAQGGD
GPEEQ
//
