ID E1BBJ9_BOVIN Unreviewed; 497 AA.
AC E1BBJ9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=G protein-coupled receptor 135 {ECO:0000313|Ensembl:ENSBTAP00000005938.5};
GN Name=GPR135 {ECO:0000313|Ensembl:ENSBTAP00000005938.5,
GN ECO:0000313|VGNC:VGNC:29549};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005938.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000005938.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005938.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000005938.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005938.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_005192483.1; XM_005192426.3.
DR RefSeq; XP_005212117.1; XM_005212060.3.
DR AlphaFoldDB; E1BBJ9; -.
DR STRING; 9913.ENSBTAP00000005938; -.
DR PaxDb; 9913-ENSBTAP00000005938; -.
DR Ensembl; ENSBTAT00000005938.5; ENSBTAP00000005938.5; ENSBTAG00000003370.5.
DR GeneID; 781195; -.
DR KEGG; bta:781195; -.
DR CTD; 64582; -.
DR VEuPathDB; HostDB:ENSBTAG00000003370; -.
DR VGNC; VGNC:29549; GPR135.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182998; -.
DR HOGENOM; CLU_048891_0_0_1; -.
DR InParanoid; E1BBJ9; -.
DR OMA; PYCLMGL; -.
DR OrthoDB; 5322435at2759; -.
DR TreeFam; TF333332; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000003370; Expressed in spermatid and 30 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR22752; G PROTEIN-COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22752:SF3; G-PROTEIN COUPLED RECEPTOR 135; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 97..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..392
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 51806 MW; 0434569C2752CDF8 CRC64;
MEEQPPPPLV RPPVSTALSG SPHPGAPSPA GTPGGTSSAA TAVAVLSFST AAAAALGNRS
DVSGADSTGA AAGGGLGGRG AAGAAGRPPL GPEAAPLLSH GAAVAAQALV LLLIFLLSSL
GNCAVMGTIV KHRQLRTVTN AFILSLSLSD LLTALLCLPA AFLDLFTPPG GPAPAATAAA
AGPWSGFCAA SRFFSSCFGI VSTLSLALIS LDRYCAIVRP PREKIGRRRA LQLLAGAWLA
ALGFSLPWEL LLTPREAPAA AQSFHRCLYR TSPDPAQLGA AYSVGLVVAC YLLPFLLMCF
CHYHICKTVR LSDVRVRPLT TYARVLRFFS DVRTATTVLI MIVSVICCWG PYCFLVLLAA
ARRAQAAQSP SLLNVVAVWL TWANGAINPV IYAVRNPNIS MLLGRNREEG YRTRNVDALL
PNQGRALQAG TLNLLRNRCT NRLGAWSTMS SSNPTSGVAG DMAMWARKNP VVLFCREGPP
DPVTAAAKQS ESGDTSL
//
