ID E1BC70_BOVIN Unreviewed; 350 AA.
AC E1BC70;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=VPS37C subunit of ESCRT-I {ECO:0000313|Ensembl:ENSBTAP00000010607.4};
GN Name=VPS37C {ECO:0000313|Ensembl:ENSBTAP00000010607.4,
GN ECO:0000313|VGNC:VGNC:36821};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000010607.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000010607.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000010607.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000010607.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000010607.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR RefSeq; NP_001193079.1; NM_001206150.1.
DR RefSeq; XP_005226917.1; XM_005226860.3.
DR AlphaFoldDB; E1BC70; -.
DR SMR; E1BC70; -.
DR STRING; 9913.ENSBTAP00000010607; -.
DR PaxDb; 9913-ENSBTAP00000010607; -.
DR Ensembl; ENSBTAT00000010607.5; ENSBTAP00000010607.4; ENSBTAG00000008064.5.
DR GeneID; 613817; -.
DR KEGG; bta:613817; -.
DR CTD; 55048; -.
DR VEuPathDB; HostDB:ENSBTAG00000008064; -.
DR VGNC; VGNC:36821; VPS37C.
DR eggNOG; KOG3270; Eukaryota.
DR GeneTree; ENSGT00950000183012; -.
DR HOGENOM; CLU_067118_0_0_1; -.
DR InParanoid; E1BC70; -.
DR OMA; PMYRAGY; -.
DR TreeFam; TF321840; -.
DR Reactome; R-BTA-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000008064; Expressed in pigment epithelium of eye and 103 other cell types or tissues.
DR GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37C; 1.
DR Pfam; PF07200; Mod_r; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 78..167
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 32..121
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 166..234
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..350
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 350 AA; 38070 MW; 37D4E915C937E726 CRC64;
METLKDKTLE ELEEMQNDPE AIDRLAQDSP EVQDLQLERE MALATNRSLA ERNLEFQGPL
EISRSNLSDK YQELRKLVER YQEQKAKLEK FSSALQLGTL LDLLQIESMK IEEESEAMAE
KFLEGEVPLD TFLENFSSMR TLSHLRRVRV EKLQDVMKKP RASLEPAGDT PPPRPPPPLH
PGPQTTPPPA EDAQPQPPQP SVVPPYPLPY SPSPGMPVGP TAHGALPPAP FPVVSQPSFS
YSGPLGPPYA AAQPGTRAPS GYSWSPQRSM PPRPGYPVAP TGASGPGYPV VGGRAPSPGY
PQQPPYLSTG GKPPYPTQPQ PSGPLQPPYP PGPAPPYGFP PPQGPTWPGY
//