ID E1BDY7_BOVIN Unreviewed; 1575 AA.
AC E1BDY7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Plexin C1 {ECO:0000313|Ensembl:ENSBTAP00000014932.5};
GN Name=PLXNC1 {ECO:0000313|Ensembl:ENSBTAP00000014932.5,
GN ECO:0000313|VGNC:VGNC:33064};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000014932.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000014932.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000014932.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000014932.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000014932.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_001179410.1; NM_001192481.1.
DR RefSeq; XP_005206170.1; XM_005206113.3.
DR RefSeq; XP_015326409.1; XM_015470923.1.
DR RefSeq; XP_015326411.1; XM_015470925.1.
DR Ensembl; ENSBTAT00000014932.6; ENSBTAP00000014932.5; ENSBTAG00000011245.6.
DR Ensembl; ENSBTAT00000077030.1; ENSBTAP00000067397.1; ENSBTAG00000011245.6.
DR GeneID; 518168; -.
DR KEGG; bta:518168; -.
DR CTD; 10154; -.
DR VEuPathDB; HostDB:ENSBTAG00000011245; -.
DR VGNC; VGNC:33064; PLXNC1.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_004205_0_0_1; -.
DR OMA; QFDGGSC; -.
DR OrthoDB; 1387371at2759; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000011245; Expressed in neutrophil and 101 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00102; IPT; 2.
DR CDD; cd12789; RasGAP_plexin_C1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF4; PLEXIN-C1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 2.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 2.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022777};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1575
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157025"
FT TRANSMEM 952..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1092..1113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..455
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1575 AA; 177148 MW; 0B0C8949027E0A7F CRC64;
MEVSRRKVPP RPPRPAALLP LLAYLLALAA PGQGADEPVW RSEQAIGAIA VSREDGVFVA
SGSCLDQLDY SLEHRLSRLY RDQAGNCSEP VPLTPPARPR PGSSFSKLLL PYREGAAGLE
GLLLTGWTFD RGACEVRPLG NLSRSSLRNG TEVVSCHPQG STAGVVYYAN DTQSWYLAVA
ATYVLPESET ASRCNPAASD RETAIALKDT GKRSLATKET GRLKLRDGGG SLHFVDAFLW
NGSVYFPYYP YNYSTGAATG WPSMARIAKS SEMLLFQGQA ALNCGHGRPD GRRLLLSSSL
VEALDVWAGV FSAATGEDQE KRSPTTTALC LFRMSEIQAR TKICRWDFEI DNNENNCKNE
DEPEKVEPIA SSTLIHSDLT SVYGTVVMNR TVLFLGTGDG QLLKVILSEN LASNCPEVIY
EIKEETPVFY KLVPHPKKNI YIYLTAGKEV RRIRVANCGK HKSCWECLAA TDPHCGWCHS
LQRCTFKEDC EHLNNSENWL DVLSGAKKCP QIHLFRSSKD KTTVTVVGSF SPRHSECVVK
NVDTGRMLCK GKSAHNETCT CIIPTRTAYK DVLVVNMTFS FGSWRVSKRF NFTNCSSLRE
CPGCIRTGCA WCKSERKCIH PFTACDPLDY KRNQDLCPVA FQKWTPPKTA GEGRFKENMS
NRTTWGLQVF SVTSIEPQKI STLGKSNVTV TGANFTEASN ITMILKGTST CDKDVIQVSH
VVNATHMQFS LPSSRKEMKD VCIQFDGGNC ASVGPLSYVA LPHCSLIYPA TTWISGGQNI
TIMGRNFDVI DNLIFSQEVK EKNVSEYCMA NSCRFLAPSL KSSKGPINVT VKLRVQETAL
DCGSLQYLDD PRFTGYRAES EVDTELEVKI QKENDNFNIS KEDIEITLFY GKNKSLNCSF
ENITRNQDLT TIFCKIKHIT AANSIATSSK KVDVKLGNLK LSVERESVLS PWYFLIGLPI
LLVFVIFVAV GVTRHKSKEL SRKQSQQLEL LESELRKEIR DGFAELQMDK LDVVDSFGTV
PFLDYKHFAL RTFFPESGGF THIFTEDMHN RDASDKNESL TALDALICNK SFLVTVIHTL
EKQKNFSVKD RCLFASFLTI ALQTKLVYLT SILEVLTRDL MEQCSNMQPK LMLRRTESVV
EKLLTNWMSV CLSGFLRETV GEPFYLLVTT LNQKINKGPV DVITCKALYT LNEDWLLWQV
PEFSTVALTV TFEKIPENES ADVCRNISVN VLDCDTIGQA KEKIFQAFLS KNGSPYGLQL
NEIGLELQVG TRHKELLDID SSSVILEDGI TKLNTIGHYE ISNGSTIKVF KKIANFTSDV
EYTEDHCHLI LPDSEAFQDV QGKRHRGKHK FKVKEMYLTK LLSTKVAIHS VLEKLFRSIW
SLPNSRAPFA IKYFFDFLDA QAENKKITDP DVVHIWKTNS LPLRFWVNIL KNPQFVFDIK
KTPHIDGCLS VIAQAFMDAF SLTEQQLGKE APTNKLLYAK DIPTYKEEVK SYYKAIRDLP
PLSSSEMEEF LTQESKKHEN EFNEEVALTE IYKYIIKYFD EILNKLERER GLEEAQKQLL
HVKVLFEEKK KCKWM
//
