ID E1BE25_BOVIN Unreviewed; 2699 AA.
AC E1BE25;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Filamin C {ECO:0000313|Ensembl:ENSBTAP00000008207.6};
GN Name=FLNC {ECO:0000313|Ensembl:ENSBTAP00000008207.6,
GN ECO:0000313|VGNC:VGNC:29035};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000008207.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000008207.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008207.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000008207.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008207.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR Ensembl; ENSBTAT00000008207.6; ENSBTAP00000008207.6; ENSBTAG00000006253.6.
DR VEuPathDB; HostDB:ENSBTAG00000006253; -.
DR VGNC; VGNC:29035; FLNC.
DR eggNOG; KOG0518; Eukaryota.
DR GeneTree; ENSGT00940000153588; -.
DR HOGENOM; CLU_000783_0_0_1; -.
DR TreeFam; TF313685; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000006253; Expressed in gluteus medius and 102 other cell types or tissues.
DR ExpressionAtlas; E1BE25; baseline and differential.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21310; CH_FLNC_rpt1; 1.
DR CDD; cd21314; CH_FLNC_rpt2; 1.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 23.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E1BE25};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 37..143
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 160..263
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 271..369
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 371..469
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 470..540
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 548..640
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 644..740
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 741..843
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 844..942
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 943..1038
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1039..1131
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1132..1226
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1227..1326
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1327..1419
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1455..1513
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1514..1610
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1623..1714
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1759..1828
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1828..1920
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1918..2007
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2010..2102
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2195..2280
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2283..2375
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2377..2470
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2474..2566
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2604..2698
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2166..2187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2214..2234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2166..2184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2699 AA; 288137 MW; C4AC32D7F924E7CF CRC64;
MMNNSGYSEA PGFGLGDEVD DMPSTEKDLA EDAPWKKIQQ NTFTRWCNEH LKCVGKRLTD
LQRDLSDGLR LIALLEVLSQ KRMYRKFHPR PNFRQMKLEN VSVALEFLER EHIKLVSIDS
KAIVDGNLKL ILGLIWTLIL HYSISMPMWE DEDDEDARKQ TPKQRLLGWI QNKVPQLPIT
NFNRDWQDGK ALGALVDNCA PGLCPDWEAW DPNQPVENAR EAMQQADDWL GVPQVIAPEE
IVDPNVDEHS VMTYLSQFPK AKLKPGAPVR SKQLNPKKAI AYGPGIEPQG NTVLQPAHFT
VQTVDAGIGE VLVYIEDPEG HTEEAKVVPN NDKNRTYAVS YVPKVAGLHK VTVLFAGQNI
ERSPFEVNVG MALGDANKVS ARGPGLEPVG NVANKPTYFD IYTAGAGTGD VAVVIVDPQG
RRDTVEVALE DKGDSTFRCT YRPVMEGPHT VHVAFAGAPI TRSPFPVHVA EACNPNACRA
SGRGLQPKGV RVKEVADFKV FTKGAGSGEL KVTVKGPRGT EEPVKVREAG DGVFESPRSP
DPFEVQVSPE AGIQKVRAWG PGLETGQVGK SADFVVEAIG TEVGTLGFSI EGPSQAKIEC
DDKGDGSCDV RYWPTEPGEY AVHVICDDED IRDSPFIAHI QPAPPDCFPD KVKAFGPGLE
PTGCIVDKPA EFTIDARAAG KGDLKLYAQD ADGCPIDIKV IPNGDGTFRC SYVPTKPIKH
TIIVSWGGVN VPKSPFRVNV GEGSHPERVK VYGPGVEKTG LKANEPTYFT VDCSEAGQGD
VSIGIKCAPG VVGPAEADID FDIIKNDNDT FTVKYTPPGA GRYTIMVLFA NQEIPASPFH
IKVDPSHDAS KVKAEGPGLN RTGVEVGKPT HFTVLTKGAG KAKLDVHFAG AAKGEAVRDF
EIIDNHDYSY TVKYTAVQQG NMAVTVTYGG DPVPKSPFVV NVAPPLDLSK VKVQGLNSKV
AVGQEQAFSV NTRGAGGQGQ LDVRMTSPSR RPIPCKLEPG GGAETQAVRY MPPEEGPYKV
DITYDGHPVP GSPFAVEGVL PPDPSKVCAY GPGLKGGLVG TPAPFSIDTK GAGTGGLGLT
VEGPCEAKIE CQDNGDGSCA VSYLPTEPGE YTINILFAEA HIPGSPFKAT IRPVFDPSKV
RASGPGLERG KAGEAATFTV DCSEAGEAEL TIEILSDAGV KAEVLIHNNA DGTYHITYSP
AFPGTYTITI KYGGHPVPKF PTRVHVQPAV DTSGVKVSGP GVEPHGVLRE VTTEFTVDAR
SLTATGGNHV TARVLNPSGA KTDTYVTDNG DGTYRVQYTA YEEGAHLVEV LYDDVAVPKS
PFRVGVTEGC DPTRVRAFGP GLEGGLVNKA NRFTVETRGA GTGGLGLAIE GPSEAKMSCK
DNKDGSCTVE YIPFTPGDYD VNITFGGRPI PGGPGTPDLH SGLQPSWPGA PAGGRAGPHR
YGVSGAGWKE PERVPRGSAD YSLCPGVAEP VEVRDNGDGT HTVHYTPATD GPYTVAVKYA
DQEVPRSPFK IKVLPAHDAS KVRASGPGLN ASGIPASLPV EFTIDARDAG EGLLTVQILD
PEGKPKKANI RDNGDGTYTV SYLPDMSGRY TITIKYGGDE IPYSPFRIHA LPTGDASKCL
VTVSIGGHGL GACLGPRIQI GEETVITVDA KAAGKGKVTC TVSTPDGAEL DVDVVENHDG
TFDIYYTAPE PGKYVITIRF GGEHIPNSPF HVLACEAMPR VEEPPDVPQL HRPSAYPTHW
ATEEPVVPAE PMESMLRPFN LVIPFTVQKG ELTGEVRMPS GKTARPNITD NKDGTITVRY
APTEKGLHQM GIKYDGNHIP GSPLQFYVDA INSRHVSAYG PGLSHGMVNK PATFTIVTKD
AGEGGLSLAV EGPSKAEITC KDNKDGTCTV SYLPTAPGDY SIIVRFDDKH IPGSPFTAKI
TGDDSMRTSQ LNVGTSTDVS LKITESDLSQ LTASIRAPSG NEEPCLLKRL PNRHIGISFT
PKEVGEHVVS VRKSGKHVTN SPFKILVGPS EIGDASKVRV WGKGLSEGHT FQVAEFIVDT
RNAGYGGLGL SIEGPSKVDI NCEDMEDGTC KVTYCPTEPG TYIINIKFAD KHVPGSPFTV
KVTGEGRMKE SITRRRQAPS IATIGSTCDL NLKIPGNWFQ MVSAQERLTR TFTRSSHTYT
RTERTEISKT RGGETKREVR VEESTQVGGD PFPAVFGDFL GRERLGSFGS ITRQQEGEAS
SQDMTAQVTS PSGKTEAAEI VEGEDSAYSV RFVPQEMGPH TVTVKYRGQH VPGSPFQFTV
GPLGEGGAHK VRAGGTGLER GVAGVPAEFS IWTREAGAGG LSIAVEGPSK AEIAFEDRKD
GSCGVSYVVQ EPGDYEVSIK FNDEHIPDSP FVVPVASLSD DARRLTVTSL QETGLKVNQP
ASFAVQLNGA RGVIDARVHT PSGAVEECYV SELDSDKHTI RFIPHENGVH SIDVKFNGAH
IPGSPFKIRV GEQSQAGDPG LVSAYGPGLE GGTTGVSSEF IVNTLNAGSG ALSVTIDGPS
KVQLDCRECP EGHVVTYTPM APGNYLIAIK YGGPQHIVGS PFKAKVTGPR LSGGHSLHET
STVLVETVTK SSSSRGSSYS SIPKFSSDAS KVVTRGPGLS QAFVGQKNSF TVDCSKAGTN
MMMVGVHGPK TPCEEVYVKH MGNRVYNVTY TVKEKGDYIL IVKWGDESVP GSPFKVNVP
//
