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Database: UniProt
Entry: E1BE29_BOVIN
LinkDB: E1BE29_BOVIN
Original site: E1BE29_BOVIN 
ID   E1BE29_BOVIN            Unreviewed;      4960 AA.
AC   E1BE29;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   13-FEB-2019, entry version 73.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSBTAP00000053650};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSBTAP00000053650,
GN   ECO:0000313|VGNC:VGNC:34234};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000053650, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000053650, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053650,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000053650}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053650};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; DAAA02061499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02061500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02061501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02061502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02061503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02061504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02061505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02061506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02061507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02061508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9913.ENSBTAP00000053650; -.
DR   PaxDb; E1BE29; -.
DR   Ensembl; ENSBTAT00000061611; ENSBTAP00000053650; ENSBTAG00000022886.
DR   VGNC; VGNC:34234; RYR2.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000154906; -.
DR   InParanoid; E1BE29; -.
DR   OMA; RFSMKDT; -.
DR   OrthoDB; 5161at2759; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-BTA-2672351; Stimuli-sensing channels.
DR   Reactome; R-BTA-5578775; Ion homeostasis.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000022886; Expressed in 8 organ(s), highest expression level in heart.
DR   ExpressionAtlas; E1BE29; baseline.
DR   GO; GO:0034704; C:calcium channel complex; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4273   4292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4493   4513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4567   4586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4703   4724       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4761   4782       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4837   4860       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       95    150       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      157    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      584    794       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1010   1207       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1342   1547       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4016   4051       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      457    477       {ECO:0000256|SAM:Coils}.
FT   COILED     3043   3063       {ECO:0000256|SAM:Coils}.
FT   COILED     4405   4431       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4960 AA;  563797 MW;  239504EE33F78BFD CRC64;
     RMMKWSCSVP RPSTKNNRNY AWRQKDLATD FASWSPLRIP RMSLQTSPSA PSCWSSPCLS
     GPCRRCWLTL WKSLKGQVLN LFFLCSMQTA QGGGHRTLLY GHAILLRHSY SGMYLCCLST
     SRSSTDKLAF DVGLQEDTTG EACWWIIHPA SKQRSEGEKV RVGDDLILVS VSSERYLHLS
     YGNGSLHVDA AFQQTLWSVA PISSGSEAAQ GYLIGGDVLR LLHGHMDECL TVPSGEHGEE
     QRRTVHYEGG AVSVHARSLW RLETLRVAWS GSHIRWGQPF RLRHVTTGKY LSLMEDKSLL
     LMDKEKADVK STAFTFRSSK EKLDVGVRKE VDGMGTSEIK YGDSVCYIQH INTGLWLTYQ
     SVDVKSVRMG SIQRKAIMHH EGHMDDGLNL SRSQHEESRT ARVIRSTVFL FNRFIRGLDA
     LSKKVKASTV DLPIESVSLS LQDLIGYFHP PDEHLEHEDK QNRLRALKNR QNLFQEEGMI
     NLVLECIDRL HVYSSAAHFA DVAGREAGES WKSILNSLYE LLAALIRGNR KNCAQFSGSL
     DWLISRLERL EASSGILEVL HCVLVESPEA LNIIKEGHIK SIISLLDKHG RNHKVLDVLC
     SLCVCHGVAV RSNQHLICDN LLPGRDLLLQ TRLVNHVSSM RPNIFLGVSE GSAQYKKWYY
     ELMVDHTEPF VTAEATHLRV GWASTEGYSP YPGGGEEWGG NGVGDDLFSY GFDGLHLWSG
     CIARTVSSPN QHLLRTDDVI SCCLDLSAPS ISFRINGQPV QGMFENFNID GLFFPVVSFS
     AGIKVRFLLG GRHGEFKFLP PPGYAPCYEA VLPKEKLKVE HSREYKQERT YTRDLLGPTV
     SLTQAAFTPI PVDTSQIVLP PHLERIREKL AENIHELWVM NKIELGWQYG PVRDDNKRQH
     PCLVEFSKLP EQERNYNLQM SLETLKTLLA LGCHVGISDE HAEEKVKKMK LPKNYQLTSG
     YKPAPMDLSF IKLTPSQEAM VDKLAENAHN VWARDRIRQG WTYGIQQDVK NRRNPRLVPY
     ALLDDRTKKS NKDSLREAVR TLLGYGYNLE APDQDHAARA EVCSGTGERF RIFRAEKTYA
     VKAGRWYFEF EAVTAGDMRV GWCRPGCQPD QELGSDERAF AFDGFKAQRW HQGNEHYGRS
     WQAGDVVGCM VDMTEHTMMF TLNGEILLDD SGSELAFKDF DVGDGFIPVC SLGVAQVGRL
     NFGKDVSTLK YFTICGLQEG YEPFAVNTNR DITMWLSKRL PQFLQVPSNH EHIEVTRIDG
     TIDSSPCLKV TQKSFGSQNS STDIMFYRLS MPIECAEVFS KTAAGGIPGT GLFGPKNDLE
     DYDVDSDFEV LMKTAHGHLV PDRGDRDKEA TKPEFNNHKD YAQEKPSRLK QRFLLRRTKP
     DYSTSHSARL TEDVLADERD DYDYLMQTST YYYSVRIFPG QEPANVWVGW ITSDFHQYDT
     GFDLDRVRTV TVTLGDEKGK VHESIKRSNC YMVCAGESLS PGQGRNNNGL EIGCVVDAAS
     GLLTFTANGK ELSTYYQVEP STKLFPAVFA QATSPNVFQF ELGRIKNVMP LSAGLFKSEH
     KNPVPQCPPR LHVQFLSHVL WSRMPNQFLK VDVSRISERQ GWLVQCMEPL QFMSLHIPEE
     NRSVDILELT EQEELLKFHY HTLRLYSAVC ALGNHRVAHA LCSHVDEPQL LYAIENKYMP
     GLLRTGYYDL LIDIHLSSYA TARLMMNNEF IVPMTEETKS ITLFPDEKKK HGLPGIGLST
     SLRPRMQFSS PSFVSINTEG YQYSPEFPLD ILKAKTIQML TEAVKEGSLH ARDPVGGTTE
     FLFVPLIKLF YTLLIMGVFH NEDLKHVLQL IEPSVFKEAA SPEEESEVAE KEPFVEDSKL
     EGAAEEENKG AKRPKEGLLQ MKLPEPVKLQ MCLLLQYLCD CQVRHRIEAI VAFSDDFVAK
     LQDNQRFRYN EVMQALNMSA ALTARKTKEF RSPPQEQINM LLNFKDDKSE CPCPEEIRDQ
     LLDFHEDLMT HCGIELDEDR SLDGNNDLTI RGRLLSLVEK VTYLKKKQAE KPVESDSKKS
     STLQQLISET MVRWAQESVI EDPELVRAMF VLLHRQYDGI GGLVRALPKT YTINGVSVED
     TINLLASLGQ IRSLLSVRMG KEEEKLMIRG LGDIMNNKVF YQHPNLMRAL GMHETVMEVM
     VNVLGGGESK EITFPKMVAN CCRFLCYFCR ISRQNQKAMF DHLSYLLENS SVGLASPAMR
     GSTPLDVAAA SVMDNNELAL ALREPDLEKV VRYLAGCGLQ SCQMLVSKGY PDIGWNPVEG
     ERYLDFLRFA VFCNGESVEE NANVVVRLLI RRPECFGPAL RGEGGNGLLA AMEEAIKIAE
     DPSRDGPSPT TGSSKTPDTE EEEDDTIHMG NAIMTFYSAL IDLLGRCAPE MHLIHAAKGE
     AIRIRSILRS LIPLGDLVGV ISIAFQMPTI AKDGNVVEPD MSAGFCPDHK AAMVLFLDRV
     YGIEVQDFLL HLLEVGFLPD LRAAASLDTA ALSATDMALA LNRYLCTAVL PLLTRCAPLF
     AGTEHHASLI DSLLHTVYRL SKGCSLTKAQ RDSIEVCLLS ICGQLRPSMM QHLLRRLVFD
     VPLLNEHAKM PLKLLTNHYE RCWKYYCLPG GWGNFGAASE EELHLSRKLF WGIFDALSQK
     KYEQELFKLA LPCLSAVAGA LPPDYMESNY VSMMEKQSSM DSEGNFNPQP VDTSNITIPE
     KLEYFINKYA EHAHDKWSMD KLANGWIYGE IYSDSSKVQP LMKPYKLLSE KEKEIYRWPI
     KESLKTMLAW GWRIERTREG DSMALYNRTR RISQTSQVSV DAAHGYSPRA IDMSNVTLSR
     DLHAMAEMMA ENYHNIWAKK KKLELEAKGG GNHPLLVPYD TLTAKEKAKD REKAQDILKF
     LQINGYAVSR GFKDLELDTP SIEKRFAYSF LQQLIRYVDE AHQYILEFDG GSRSKGEHFP
     YEQEIKFFAK VVLPLIDQYF KNHRLYFLSA ASRPLCSGGH ASNKEKEMVT SLFCKLGVLV
     RHRISLFGND ATSIVNCLHI LGQTLDARTV MKTGLESVKS ALRAFLDNAA EDLEKTMENL
     KQGQFTHTRN QPKGVTQIIN YTTVALLPML SSLFEHIGQH QFGEDLILED VQVSCYRILT
     SLYALGTSKS IYVERQRSAL GECLAAFAGA FPVAFLETHL DKHNIYSIYN TKSSRERAAL
     NLPANVEDVC PNIPSLEKLM EEIVDLAESG IRYTQMPHVM EVVLPMLCSY MSRWWEHGPE
     NNPGRAEMCC TALNSEHMNT LLGNILKIIY NNLGIDEGAW MKRLAVFSQP IINKVKPQLL
     KTHFLPLMEK LKKKAAMVVS EEDHLKSEAR GDMSEAELLI LDEFTTLARD LYAFYPLLIR
     FVDYNRAKWL KEPNQEAEDL FRMVAEVFIY WSKSHNFKRE EQNFVVQNEI NNMSFLIMDT
     KSKMSKAAVS DQERKKMKRK GDRYSMQTSL IVAALKRLLP IGLNICAPGD QELIALAKNR
     FSLKDTEDEV RDIIRSNIHL QGKLEDPAIR WQMALYKDLP NRTEDTSDPE KTVERVLDIA
     NVLFHLEQVS FCVDSVTFGL VEHPQRSKKA VWHKLLSKQR KRAVVACFRM APLYNLPRHR
     AVNLFLQGYE KSWIETEEHY FEDKLIEDLA KPGAEPPEED EGTKRVDPLH QLILLFSRTA
     LTEKCKLEED FLYMAYADIM AKSCHDEEDD DGEEEVKSFE VTGSQRSKEK EMEKQKLLYQ
     QARLHDRGAA EMVLQTISAS KGETGPMVAA TLKLGIAILN GGNSTVQQKM LDYLKEKKDV
     GFFQSLAGLM QSCSVLDLNA FERQNKAEGL GMVTEEGSGE KVLQDDEFTC DLFRFLQLLC
     EGHNSDFQNY LRTQTGNNTT VNIIISTVDY LLRVQESISD FYWYYSGKDV IDEQGQRNFS
     KAIQVAKQVF NTLTEYIQGP CTGNQQSLAH SRLWDAVVGF LHVFAHMQMK LSQDSSQIEL
     LKELMDLQKD MVVMLLSMLE GNVVNGTIGK QMVDMLVESS NNVEMILKFF DMFLKLKDLT
     SSDTFKEYDP DGKGVISKRD FHKAMESHKH YTQSETEFLL SCAETDENET LDYEEFVKRF
     HEPAKDIGFN VAVLLTNLSE HMPNDTRLQT FLELAESVLN YFQPFLGRIE IMGSAKRIER
     VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGEKEKME LFVNFCEDTI FEMQLAAQIS
     ESDLNERSAN KEESEKEKPE EQGPRMGFFS IMTVKSALFA LRYNILTLMR MLSLKSLKKQ
     MKKVKKMTVK DMITAFFTSY WSILMSLLHF VASVFRGFSR IIGSLLLGGS LVEGAKKIKV
     AELLANMPDP TQDEVRGDGE EGERKTLEGA LPSEDLTDLK ELSEESDLLS DIFGLDLKRE
     GGQYKLIPHN PNAGLSDLMS NPVPIPEVQE KFQEQKAKEE EKEEKEESKS EPEKAEGEDG
     EKEEKAKEDK GKQKLRQLHT HRYGEPEVPE SAFWKKIIAY QQKLLNYFAR NFYNMRMLAL
     FVAFAINFIL LFYKVSTSSV VEGKELPTRS SSENARVSSL DSSSPRIIAV HYVLEESSGY
     MEPTLRILAI LHTVISFFCI IGYYCLKVPL VIFKREKEVA RKLEFDGLYI TEQPSEDDIK
     GQWDRLVINT QSFPNNYWDK FVKRKVMDKY GEFYGRDRIS ELLGMDKAAL DFSDAREKKK
     PKKDSSLSAV LNSIDVKYQM WKLGVVFTDN SFLYLAWYMT MSILGHYNNF FFAAHLLDIA
     MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DGDTPDMKCD
     DMLTCYMFHM YVGVRAGGGI GDEIEDPAGD EYEIYRIIFD ITFFFFVIVI LLAIIQGLII
     DAFGELRDQQ EQVKEDMETK CFICGIGNDY FDTVPHGFET HTLQEHNLAN YLFFLMYLIN
     KDETEHTGQE SYVWKMYQER CWEFFPAGDC FRKQYEDQLN
//
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