ID E1BEE0_BOVIN Unreviewed; 499 AA.
AC E1BEE0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Target of myb1 like 2 membrane trafficking protein {ECO:0000313|Ensembl:ENSBTAP00000005210.6};
GN Name=TOM1L2 {ECO:0000313|Ensembl:ENSBTAP00000005210.6,
GN ECO:0000313|VGNC:VGNC:36219};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005210.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000005210.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005210.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000005210.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005210.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TOM1 family. {ECO:0000256|ARBA:ARBA00007708,
CC ECO:0000256|PIRNR:PIRNR036948}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005220457.1; XM_005220400.3.
DR AlphaFoldDB; E1BEE0; -.
DR PaxDb; 9913-ENSBTAP00000005210; -.
DR Ensembl; ENSBTAT00000005210.6; ENSBTAP00000005210.6; ENSBTAG00000003983.6.
DR GeneID; 616315; -.
DR CTD; 146691; -.
DR VEuPathDB; HostDB:ENSBTAG00000003983; -.
DR VGNC; VGNC:36219; TOM1L2.
DR eggNOG; KOG1087; Eukaryota.
DR GeneTree; ENSGT00940000156940; -.
DR HOGENOM; CLU_043812_3_0_1; -.
DR TreeFam; TF314105; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000003983; Expressed in prefrontal cortex and 105 other cell types or tissues.
DR ExpressionAtlas; E1BEE0; baseline and differential.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR014645; TOM1.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR13856:SF31; TOM1-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR13856; VHS DOMAIN CONTAINING PROTEIN FAMILY; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036948; TOM1; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR036948};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036948}.
FT DOMAIN 20..152
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 211..299
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT REGION 164..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 54422 MW; A02F75F201ED06AF CRC64;
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA IRALKKRLNG
NRNYREVMLA LTVLETCVKN CGHRFHVLVA NRDFIDSVLV KVISPKNSPP TIVQDKVLAL
IQAWADAFRS SPDLTGVVHA YEELKRKGVE FPMADLDALS PIHTPQRSVP EVDPAATMPK
SQSQLRTSSS SYSAPQAPAL STAGPITANS EQIARLRSEL DVVRGNTKVM SEMLTEMVPG
QEDSSDLELL QELHRTCRAM QQRVVELISR VCNEEVTEEL LHVNDDLNNV FLRYERFERY
RSGRSAQNAT NGVLSEVTED NLIDLGPGSP AVVSPTVGST APPSSLSSQL AGLDLGTESV
SGTLSSLQQC QPRDSFDVFA QTRGSASAEQ RNPPTYEDPQ AVGVPAVAVD GRKQSSEVIP
VVQPSVMDDI EVWLRTDLKG DDLEEGVTSE EFDKFLEERA KAAEMVPSLP SPPADAPAPA
SNPSGRKKPE RSEDALFAL
//
