ID E1BEL9_BOVIN Unreviewed; 562 AA.
AC E1BEL9;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Coenzyme A synthase {ECO:0000313|Ensembl:ENSBTAP00000027845.5};
GN Name=COASY {ECO:0000313|Ensembl:ENSBTAP00000027845.5,
GN ECO:0000313|VGNC:VGNC:50148};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000027845.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000027845.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000027845.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000027845.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000027845.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; E1BEL9; -.
DR PaxDb; 9913-ENSBTAP00000027845; -.
DR Ensembl; ENSBTAT00000027845.5; ENSBTAP00000027845.5; ENSBTAG00000046746.2.
DR VEuPathDB; HostDB:ENSBTAG00000046746; -.
DR VGNC; VGNC:50148; COASY.
DR eggNOG; KOG3220; Eukaryota.
DR eggNOG; KOG3351; Eukaryota.
DR GeneTree; ENSGT00550000075078; -.
DR HOGENOM; CLU_027827_1_0_1; -.
DR OrthoDB; 460288at2759; -.
DR TreeFam; TF105783; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000046746; Expressed in ruminant reticulum and 105 other cell types or tissues.
DR ExpressionAtlas; E1BEL9; baseline and differential.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:Ensembl.
DR GO; GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IEA:Ensembl.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:Ensembl.
DR CDD; cd02022; DPCK; 1.
DR CDD; cd02164; PPAT_CoAS; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR Pfam; PF01121; CoaE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..562
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030168155"
FT DOMAIN 195..337
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 562 AA; 61800 MW; E0B6A8C828E0D376 CRC64;
MAVFRSGLLV LTTPLTSLAP RLAPILSSAA RLVNHTLYVH LQPGMSLGGP AQPQSSPVQA
TFEVLDFITH LYAGADVHRH LDVRILLTNI RTKSCLPPLP TSVQNLAHPP EVVLTDFQTL
DGSQYNPAKQ QLERYATSCY SCCPKLSSVL LYPDYGPAVS PAGSLGVHLP STIRPTSPVA
RSAKQPVRGH QRGAVGGTFD RLHNAHKVLL SVACILAQEQ LVVGVADKDL LKSKLLPELL
QPYTERVEHL SEFLVDIKPS LTFDIIPLLD PYGPAGSDPS LEFLVVSEET YRGGMAVNRF
RLENDLEELT LYQIQLLKDL NHKENEEDKV SSSSFRQQML GNLLRPPYKR PELPPGFYVI
GLTGISGSGK SSVAQRLKGL GAYIIDSDHL GHRAYAPGGP AYQPVVEAFG TDILHKDGII
NRKVLGSRVF GNKKQLKILT DIMWPVIAKL AREEMDQAVA EGKRVCVIDA AMLLEAGWQN
MVHEVWTVVI PETEAIRRIM ERDGLSEAAA QSRLQSQMSG QQLVDQSHVV LSTMWEPHVT
QRQVEKAWAL LQKRISEAPS GP
//
