GenomeNet

Database: UniProt
Entry: E1BES3_BOVIN
LinkDB: E1BES3_BOVIN
Original site: E1BES3_BOVIN 
ID   E1BES3_BOVIN            Unreviewed;      1300 AA.
AC   E1BES3;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   24-JAN-2024, entry version 68.
DE   SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSBTAP00000005613.6};
GN   Name=EVC2 {ECO:0000313|Ensembl:ENSBTAP00000005613.6,
GN   ECO:0000313|VGNC:VGNC:28635};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005613.6, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000005613.6, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005613.6,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000005613.6}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005613.6};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   SMR; E1BES3; -.
DR   Ensembl; ENSBTAT00000005613.6; ENSBTAP00000005613.6; ENSBTAG00000004277.6.
DR   VEuPathDB; HostDB:ENSBTAG00000004277; -.
DR   VGNC; VGNC:28635; EVC2.
DR   GeneTree; ENSGT00940000154127; -.
DR   HOGENOM; CLU_007621_0_0_1; -.
DR   InParanoid; E1BES3; -.
DR   OMA; IFFAQIK; -.
DR   OrthoDB; 4261679at2759; -.
DR   TreeFam; TF331379; -.
DR   Reactome; R-BTA-5632684; Hedgehog 'on' state.
DR   Reactome; R-BTA-5635838; Activation of SMO.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000004277; Expressed in aorta and 102 other cell types or tissues.
DR   GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR   InterPro; IPR022076; Limbin.
DR   InterPro; IPR026501; Limbin/EVC.
DR   PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR   PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR   Pfam; PF12297; EVC2_like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..1300
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018564695"
FT   TRANSMEM        288..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          780..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          454..481
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          698..725
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1300 AA;  147262 MW;  9C07ED34AA6C9608 CRC64;
     MDTPRGPGRA TWVLAGSLLA AALALPAESR NLGQLPAGQV PLQHPLGPQP LRDPHTVPGA
     GLERTAQDLP LGIWPSVENS HVTTPEEAPF GMKFSKEIEV FNPPLASSAS SGPWVHSVFA
     FTHSWPRKTL FKRDSAVTHR LYGDISRDFQ GTSENGVIFQ KCAVVSVQSE WPSAHVRLFV
     NNTRTPTAAN LSDLFLLDNI TGLTIRESAG NQTSRGFQAF RKKFLQVGDS FSVSYTASLE
     ARDVGSGDIL LLPAQLSFQS SSPNRTQLKA PFTITAEEKI TVLPNHGLHA AGFCVAFILS
     LVLTWAVLFF MVRYQCVKGS SLTRHQVQHH ENKLEHSQFT SADGVNEDLA LNDQMIDILS
     SEDPGSMLQA LEELEIATLN RADSDLEACR TQISKDIIAL LLKNLTSSGQ LSPQVERRMG
     AVFKKQFLLL EKEIQEEYDR KMVALTAECD LETRKKTESQ YQREMAAMEE AEEVLKRVSE
     RSAVECSSLL RTLHGLEQEH LRRSLALQQE EDLAKAHRQL AIFQRNELHN IFFTQIKSAI
     FKGELKPEAA KMLLQDYSKI QESVEELMDF FQASKRYHLS KRFGHREYLV QNIQSSETRM
     QGLLSTASAQ LTLLIQKHER AGYLDEDQMQ VLLERAQTEV FSIKQKLDND LKQEKKKLHQ
     KLIIKRRREM LQKHKEQRRE QLSIAEASGA AEDAGQYLGQ WRGLMAEHSA ALEELQERLD
     QAALDELRAL TLSLSEKATE ELRRLQNSGM TQELLKRGVP WLFLQQILEE HSRDLAARAE
     RLEGEERDRG QEGVQSVRQR LKDDALEAST EEQAELRHWE HLIFTKLCSS AFSLSEEELL
     GMRQEVHGCF AQMDRSLALP KIRARVLLQR FQTAWREAEF LKLDQAMTAP ELQPQSKARK
     PRSKSRSKID LLKKCTEDKI QLFKEQAPED LVEKVRGELL RERVQQLEAQ EGLFAESLVS
     LQFQKAARMA RTLWAYTALL SIQDLLLEEL NSSETLTKSA CMQILESHSP ELQELERKLE
     DQLAHQEAAQ LQRALDSWQQ WAGEGPALLQ EPEETDSERH VSAVLQRALS KGQKLLEYHQ
     QSLREEQEDS VVLEDLLENM ETDTFVTLYG QELRLASYLS KLTMLPGGTL RRLLTVALPA
     ASQAELLAVL DSVGQKHQDH SVENDGSRVQ ADLGRRGKHQ GWWQALESKL RGELINRGLE
     KMLWAQKRKE SILKKTCPPL RERVIFSGKR SWPHLSLEST DELTPVPIVG AEAVDLLNTG
     EKLFIFRNPK EPEISLHVPP RKKKKNFLNA KKAAWALGLN
//
DBGET integrated database retrieval system