ID E1BES3_BOVIN Unreviewed; 1300 AA.
AC E1BES3;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSBTAP00000005613.6};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSBTAP00000005613.6,
GN ECO:0000313|VGNC:VGNC:28635};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005613.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000005613.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005613.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000005613.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005613.6};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR SMR; E1BES3; -.
DR Ensembl; ENSBTAT00000005613.6; ENSBTAP00000005613.6; ENSBTAG00000004277.6.
DR VEuPathDB; HostDB:ENSBTAG00000004277; -.
DR VGNC; VGNC:28635; EVC2.
DR GeneTree; ENSGT00940000154127; -.
DR HOGENOM; CLU_007621_0_0_1; -.
DR InParanoid; E1BES3; -.
DR OMA; IFFAQIK; -.
DR OrthoDB; 4261679at2759; -.
DR TreeFam; TF331379; -.
DR Reactome; R-BTA-5632684; Hedgehog 'on' state.
DR Reactome; R-BTA-5635838; Activation of SMO.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000004277; Expressed in aorta and 102 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1300
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018564695"
FT TRANSMEM 288..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 780..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 454..481
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 698..725
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1300 AA; 147262 MW; 9C07ED34AA6C9608 CRC64;
MDTPRGPGRA TWVLAGSLLA AALALPAESR NLGQLPAGQV PLQHPLGPQP LRDPHTVPGA
GLERTAQDLP LGIWPSVENS HVTTPEEAPF GMKFSKEIEV FNPPLASSAS SGPWVHSVFA
FTHSWPRKTL FKRDSAVTHR LYGDISRDFQ GTSENGVIFQ KCAVVSVQSE WPSAHVRLFV
NNTRTPTAAN LSDLFLLDNI TGLTIRESAG NQTSRGFQAF RKKFLQVGDS FSVSYTASLE
ARDVGSGDIL LLPAQLSFQS SSPNRTQLKA PFTITAEEKI TVLPNHGLHA AGFCVAFILS
LVLTWAVLFF MVRYQCVKGS SLTRHQVQHH ENKLEHSQFT SADGVNEDLA LNDQMIDILS
SEDPGSMLQA LEELEIATLN RADSDLEACR TQISKDIIAL LLKNLTSSGQ LSPQVERRMG
AVFKKQFLLL EKEIQEEYDR KMVALTAECD LETRKKTESQ YQREMAAMEE AEEVLKRVSE
RSAVECSSLL RTLHGLEQEH LRRSLALQQE EDLAKAHRQL AIFQRNELHN IFFTQIKSAI
FKGELKPEAA KMLLQDYSKI QESVEELMDF FQASKRYHLS KRFGHREYLV QNIQSSETRM
QGLLSTASAQ LTLLIQKHER AGYLDEDQMQ VLLERAQTEV FSIKQKLDND LKQEKKKLHQ
KLIIKRRREM LQKHKEQRRE QLSIAEASGA AEDAGQYLGQ WRGLMAEHSA ALEELQERLD
QAALDELRAL TLSLSEKATE ELRRLQNSGM TQELLKRGVP WLFLQQILEE HSRDLAARAE
RLEGEERDRG QEGVQSVRQR LKDDALEAST EEQAELRHWE HLIFTKLCSS AFSLSEEELL
GMRQEVHGCF AQMDRSLALP KIRARVLLQR FQTAWREAEF LKLDQAMTAP ELQPQSKARK
PRSKSRSKID LLKKCTEDKI QLFKEQAPED LVEKVRGELL RERVQQLEAQ EGLFAESLVS
LQFQKAARMA RTLWAYTALL SIQDLLLEEL NSSETLTKSA CMQILESHSP ELQELERKLE
DQLAHQEAAQ LQRALDSWQQ WAGEGPALLQ EPEETDSERH VSAVLQRALS KGQKLLEYHQ
QSLREEQEDS VVLEDLLENM ETDTFVTLYG QELRLASYLS KLTMLPGGTL RRLLTVALPA
ASQAELLAVL DSVGQKHQDH SVENDGSRVQ ADLGRRGKHQ GWWQALESKL RGELINRGLE
KMLWAQKRKE SILKKTCPPL RERVIFSGKR SWPHLSLEST DELTPVPIVG AEAVDLLNTG
EKLFIFRNPK EPEISLHVPP RKKKKNFLNA KKAAWALGLN
//