ID E1BGU6_BOVIN Unreviewed; 529 AA.
AC E1BGU6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Cation channel sperm associated 2 {ECO:0000313|Ensembl:ENSBTAP00000042959.3};
GN Name=CATSPER2 {ECO:0000313|Ensembl:ENSBTAP00000042959.3,
GN ECO:0000313|VGNC:VGNC:26794};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000042959.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000042959.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000042959.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000042959.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000042959.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001179406.1; NM_001192477.1.
DR RefSeq; XP_015314813.1; XM_015459327.1.
DR AlphaFoldDB; E1BGU6; -.
DR STRING; 9913.ENSBTAP00000042959; -.
DR Ensembl; ENSBTAT00000045580.4; ENSBTAP00000042959.3; ENSBTAG00000032130.4.
DR GeneID; 517699; -.
DR KEGG; bta:517699; -.
DR CTD; 117155; -.
DR VEuPathDB; HostDB:ENSBTAG00000032130; -.
DR VGNC; VGNC:26794; CATSPER2.
DR GeneTree; ENSGT00910000144338; -.
DR HOGENOM; CLU_038828_0_0_1; -.
DR InParanoid; E1BGU6; -.
DR OMA; QVVWPRD; -.
DR OrthoDB; 5392781at2759; -.
DR Reactome; R-BTA-1300642; Sperm Motility And Taxes.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000032130; Expressed in semen and 91 other cell types or tissues.
DR GO; GO:0036128; C:CatSper complex; IBA:GO_Central.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR GO; GO:0009566; P:fertilization; IBA:GO_Central.
DR GO; GO:0030317; P:flagellated sperm motility; IBA:GO_Central.
DR GO; GO:0048240; P:sperm capacitation; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR028747; CatSper2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46923; CATION CHANNEL SPERM-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR46923:SF1; CATION CHANNEL SPERM-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 109..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..350
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 384..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..434
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 61934 MW; 79465E4141639A22 CRC64;
MATYHPSGHM QLPRADAIRS RLIDTFSLIE HLQGLSQAVP RHTIREILDS SRQKKLMLGD
QHQLVRFSIK PRHVERITHA QRLMSTLRVR CSERPPLSLW AGWVLERPIF RNFIIFLIFL
NTVVLMVEIE LLESANTQLE PLKLTLEVAA WFILLIFILE ILLMWLSSFF LFWKNAWNVF
DFVVTVLSLI PEIVVLAGVT SKPVWLQLLR ICRVLRSLKL FARFHQVRVI ILALVRALKS
MTFLLMLLLI FFYIFAVAGV YFFENYTRST RQDLEYHEFF SDLLNSIVTV FILFTLDHWY
ALLQDTWKVP EVSRTFSSIY VILWLLLGSI IFRNIIVAMM VTNFQNIRNE LNEEMTHLEV
QHKADIFKRQ IIQRRQNLIP EAQRSSISKL DARDASQQGR PSDLTESSQQ ESKQSATRKG
SKVSKSRTKS LSKRRKSTSS FSSSSSSFSS CSSVSSSRYC DLIGQLDWET HVHQNLPGLM
DMDQDERVVW PRDSLFRYFE LLEKLQYNLE ERKQLQEFAV QALMNFEDK
//
