ID E1BIF6_BOVIN Unreviewed; 4364 AA.
AC E1BIF6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Vacuolar protein sorting 13 homolog D {ECO:0000313|Ensembl:ENSBTAP00000043730.4};
GN Name=VPS13D {ECO:0000313|Ensembl:ENSBTAP00000043730.4,
GN ECO:0000313|VGNC:VGNC:55087};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000043730.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000043730.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000043730.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000043730.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000043730.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR SMR; E1BIF6; -.
DR STRING; 9913.ENSBTAP00000043730; -.
DR PaxDb; 9913-ENSBTAP00000043730; -.
DR Ensembl; ENSBTAT00000046426.4; ENSBTAP00000043730.4; ENSBTAG00000016080.6.
DR VEuPathDB; HostDB:ENSBTAG00000016080; -.
DR VGNC; VGNC:55087; VPS13D.
DR eggNOG; KOG1796; Eukaryota.
DR eggNOG; KOG1809; Eukaryota.
DR GeneTree; ENSGT00950000183083; -.
DR HOGENOM; CLU_000131_0_0_1; -.
DR InParanoid; E1BIF6; -.
DR OMA; LFGTCPT; -.
DR TreeFam; TF300316; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000016080; Expressed in neutrophil and 110 other cell types or tissues.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF141; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2633..2676
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 403..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2071..2145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..127
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 745..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2071..2088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2118..2144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4364 AA; 488366 MW; 65D4EEE2612E10FB CRC64;
MLEGLVAWVL NTYLGKYVNN LNTDQLSVAL LKGAVELENL PLKKDALKEL ELPFEVKAGL
IGKVTLQIPF YRPHVDPWVI SISSLHLIGA PEKIQDFNDE KEKLLERERK KALLQALEEK
WKNERQQKGE SYWYSVTASV VTRIVENIEL KIQDVHLRFE DGVTNPSHPF AFGICIKNVS
MQNAMNEPVQ KLMRKKQLDV AEFSIYWDVD CTLLGDLPQV ELQEAMDRSM ESRDHHYILE
PVCASALLKR NCSKEPLRSR HTPRIECDIH LETIPLKLSQ LQYRQIMEFL KELERKERQV
KFRKWKPKVA VSENCREWWY FALNANLHEI REQRKRCTWG FLLGRARDAV SYTDKYFTTL
RGGLLSADDK EEMYRIEEEQ SFEELKILRE LVHERFHKQE ELAESLREPQ LDPLGDSPGD
PGPGGGSGML QYLQSWFPGW GGWYGQQSPE GKPVEGLMAE PQEQWTPEEI LGSEEFFDPT
ADASCMNTYT KRDHVFAKLN LQLQRGTVTL LHQEQGAPQM NQSAFMQLEF SGVKLLAESL
PRRNSSLLLV RLGGLFLRDL ATEGTMFPLL VFPNPQKEVG RVSQSFGLQT TSADRSHHYP
AADPDDPVFE MLYERNPVHS HFERRLNVST RPLNIIYNPQ AIKKVADFFY KGKVHTSGFG
YQSELELRVA EAARRQYNRL KMQTKAEIRQ TLDRLLVGDF IEESKRWTVR LDISAPQVIF
PDDFKFKNPV LVVVDLGRML LTNTQDDSKR KSGDGSALEE NQFSDDEYKT PLATPPNTPP
PETSSSNGEK TPPFSGVKFS EEQLQAHLMS TKMYERYSLS FLDLQIMVGR VKDNWKHVQD
IDVGPTHVVE KFNVHLQLER RLIYTSDPKY PGAVLSGNLP DLKIHINEDK ISALKNCFAL
LTTPEMKTFD SQMKEKIFPQ GGQRGSLQDS VMNLTQSIVM LEQHTREVLV ESQLLLAEFK
VNCMQLGVES NGRYISVLKV FGTNAHFVKR PYDAEVSLTV HGLLLVDTMQ TYGADFDLLM
ASHKNLSFDI PTGSLRDSRA QSPVSGSNVA HFTSAATRNN QSATSISLDR VLTKEQESLI
KLEYQFVSSE CPSMNLDSTL QVISLQVNNL DIILNPETIV ELIGFLQKSF PKEKDELSPQ
PLMTDFERSF REQGTYQSTY EQNTEVAVEI HRLNLLLLRT VGMANGEKYG RKIATASIGG
TKVNVSMGNT FDMNGSLGCL QLMDLTQENV KNQYVVSIGN SVGYENIISD IGFYESVFVR
MEDAALTDAL SFTFVEKSKQ ECFLNLKMAS LHYNHSAKFL KELTLSMDEL EENFRSMLKS
AATKVTTVLA TKTAEYSEMV SLFETPRKAR DSFFLEENEP YGFGLGASHS DTVKLILNIN
IESPVVSIPR KPGSPELLVG HLGQIFIQNF VAGDDESRSD RLQVEIKDIK LYSLNCTQLT
GREGPGPEMS RAFCPLSGSA NANSQEEAHF TRHDFFESLH RGQAFHILNN TTIQFKLEKI
PIERESELTF SLSPDDLGAS SIMKIEGKFV NPVQVVLAKH VYEQVLQTLD NLVYSEDLNK
FPVSAASSPC PNSPLPPLST CGEPSAERKE NGLFSHSSLS NSSQKSLSVK EVKSFTQIQA
NFCISELQVQ LSGDLTLGAQ GLVSLKFQDF EVEFSKDHPQ TLSIQIALRS LLMEDLLEKN
PDSKYKNLMV SRGAPKPSSL AQKEYLSQSC PSVSNVEYPD MPRSLPSHME EAPNVFQLYQ
RPTSASRKKQ KEVQDKDYPL TPPPSPTVDE PKILAGKSKF DDSLVHINVF LVDKKHPEFS
SSYNRVNRSI DVDFNCLDVL ITLQTWVVIL DFFGIGSTAD NHAMKVPPED VLQNVKSESS
ALAESELQEP VNTKLDLKVH SLSLVLNKTT SELAKANVSK LVAHLEMIEG DLALQGSIGS
LSLSDLTSHG EFYRERFTTS GEEALIFQTF KYGRPDPLLR REHDVRVSLQ MASVQYVHTQ
RFQAEVVAFI QHFTQLQDVL GRQRAAIEGQ TVRDQAQRYS RVLLDIEAGA PVLLIPESSR
SNNLIVANLG KLKVKNKFLF AGFPGTFTLQ DKESVPSSSP TGTPKRSVRK MTSMEDLKGT
HSEGLIMMPP AGMSRGSLKS ESVPSTSTKQ QGQPATTSVG RASSSPEDHV CLLDCIVVDL
QDMDIFAAER HPREYSRVSE DSSGDLIFPS YFVLQTGGSL LTEPCRLKLQ VERNLDKEIS
HTVPDISIHG NLSSVHCSLD LCKYKLIRGL LENNLGEPIE EFMRPYDLQD PRIHTVLSGE
VYTCMCFLID MVNVSLELKD PKGKEAAGSL ARFDFKKCKL LYESFSNQTK SVNLVSHSMM
AFDTRSAGQK TSPGVTNVFT CIFQPSKSSS TTQGSIQIEL HFRSTKDSSC FTVVLNNLRV
FLIFDWLLLV HDFLHTPSDI KKPAKVTPFR HRNSSSESAV IPKTVKSGVV TKRSSLPVST
ERHLEVKVNV TGTEFVVVED VSCFDTNAII LKGTTVLTYK PRFVDRPFSG SLFGIEVFSC
RLGNEHDTAL SIVDPVQIHV ELVGNSSYQN SSGLMDAFNS EDFPPILEIQ LQALDIRLSY
NDVQLFLAIA KSIPEQANAA VPDVAALEAS SVHSYLPGAS RGGEEVREGT RHTLDPVLEL
QLARLQELGF STDDCRKALL VCQGQLKKAA SWLFKNAEPR TSLSLASNSQ QSQGAAPAWL
ISGVEMKAES VCICFIDDCM DCDVPLAELT FSRLNFLQHV RTSPEGYAHF TLSGDYYNRA
LSGWEPFIEP WPCSVSWQQQ AASRLHPPRL KLEAKAKQRL DVNITSVLID QYISTKESWM
ADYCKQDKEV DPTPSEDWMG SSVDPPCFGQ TEMKAPKRRQ PFVPFALRNH TGCTLWFATL
TTTPTRAALS HSGSPGVVPE GNGTLLDDAH NVSEWREVLT GEEIPFEFEA RGKLRHRHTH
DLRIHQLQVR VNGWEQVSPV SVDKVGTFFR YAAPDKNSSS STIGSPSSRT NIIHPQVYFS
SLPPVRVVFA VTMEGSARKV ITVRSALIVK NRLETPMELR LDSPSAPDKP VVLPAIMPGD
SFAVPLHLTS WRLQARPKGL GVFFCKAPIH WTNVVKTAEV SSSKRECHSM DTEKSRFFRF
CVAIKKENYP DYMPSNIFSD SAKQIFRQPG HTIYLLPTVV ICNLLPCELD FYVKGMPING
TLKPGKEVAL HTADTSQNIE LGVSLENFPL CKELLIPPGT QNYMVRMRLY DTNRRQLNLT
IRIVCRAEGS LKIFISAPYW LINKTGLPLI FRQDNAKTDA AGQFEEHELA RSLSPLLFCY
ADKEQPNLCT MRIGRGIHPE GMPGWCQGFS LDGGSGVRAL RVIQQGNRPG LIYNIGIDVK
KGRGRYIDTC MVIFAPRYLL DNKSSHKLAF AQREFARGQG TANPEGYIST LPGSSVVFHW
PRNDYDQLLC VRLMDVPNCI WSGGFEVNKN NSFHINMRDT LGKCFFLRVE ITLRGATYRI
SFSDTDQLPT PFRIDNFSKV PVVFTQHGVA EPRLRTEVKP MTSLDYAWDE PTLPPFITLT
VKGAGSSEIS CNMNDFQDNQ QLYYENFIYI AATYTFSGLQ EGTGRPVTSN KAVTCAELVL
DVSPKTQRVI LKKKEPGKRS QLWRMTGTGM LAHEGSSVPH NPSEPSAARS AEGSAILDIA
GLAAVTDNRY EPLMLRKPDR RRSTTQTWSF REGKLTCGLH GLVVQAKGGL SGLFDGAEVV
LGPDTSMQLL GPVPPEQQFI NQKMRPGSGM LSIRVVPDGP TRALQITDFS QRKSDRSSYE
VDELPVTERE LQKLKNPDTE QELEVLVKLE GGIGLSLINK VPEELVFASL TGINVHYTQL
ATSHMLELSI QDVQVDNQLI GTTQPFMLYV TPLSNENEVI ETGPAVQVNA VKFPSKSTLT
NIYKHLMVTA QRFTVQIEEK LLLKLLSFFG YDQAESEVEK YDENLHEKTA EQGGTPIRYY
FENLKISIPQ IKLSVFTSNK LPLDLKALKS TLGFPLIRFE DAVINLDPFT RVHPYETKDF
IINDILKHFQ EELLSQAARI LGSVDFLGNP MGLLNDVSEG VTGLIKYGNV GGLIRNVTHG
VSNSAAKFAG TLSDGLGKTM DNRHQSEREY IRYHAATSGE HLVAGIHGLA HGIIGGLTSV
ITSTVEGVKT EGGVSGFISG LGKGLVGTVT KPVAGALDFA SETAQAVRDT ATLSGPRTQA
QRVRKPRCCT GPQGLLPRYS ESQAEGQEQL FKLTDNIQDE FFIAVENIDS YCVLISSKAV
YFLRSGDYVD REAIFLEVKY DDLYHCLVSK DHGKVYVQVT KKAVNTSSGV SIPGPSHQKP
MVHVKSEVLA IKLSQEINYA KSLYYEQQLM LRLSENQEQL ELDS
//
