ID E1BIU0_BOVIN Unreviewed; 1117 AA.
AC E1BIU0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=SEC24 homolog C, COPII coat complex component {ECO:0000313|Ensembl:ENSBTAP00000003616.5};
GN Name=SEC24C {ECO:0000313|Ensembl:ENSBTAP00000003616.5,
GN ECO:0000313|VGNC:VGNC:34415};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000003616.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000003616.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003616.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000003616.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003616.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR RefSeq; XP_005226415.1; XM_005226358.3.
DR AlphaFoldDB; E1BIU0; -.
DR SMR; E1BIU0; -.
DR STRING; 9913.ENSBTAP00000003616; -.
DR Ensembl; ENSBTAT00000003616.5; ENSBTAP00000003616.5; ENSBTAG00000002791.5.
DR GeneID; 509488; -.
DR CTD; 9632; -.
DR VEuPathDB; HostDB:ENSBTAG00000002791; -.
DR VGNC; VGNC:34415; SEC24C.
DR eggNOG; KOG1984; Eukaryota.
DR GeneTree; ENSGT01060000248649; -.
DR HOGENOM; CLU_004589_1_1_1; -.
DR InParanoid; E1BIU0; -.
DR OMA; INPFMTF; -.
DR OrthoDB; 977017at2759; -.
DR TreeFam; TF300464; -.
DR Reactome; R-BTA-204005; COPII-mediated vesicle transport.
DR Reactome; R-BTA-2132295; MHC class II antigen presentation.
DR Reactome; R-BTA-5694530; Cargo concentration in the ER.
DR Reactome; R-BTA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
DR Proteomes; UP000009136; Chromosome 28.
DR Bgee; ENSBTAG00000002791; Expressed in esophagus and 105 other cell types or tissues.
DR ExpressionAtlas; E1BIU0; baseline and differential.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF5; PROTEIN TRANSPORT PROTEIN SEC24C; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E1BIU0};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 445..483
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 522..766
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 771..854
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 867..966
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 984..1057
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..273
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..324
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 120620 MW; 6F880CA560039374 CRC64;
MNVNQSAPPV PPFGQPQPVY PGYHQSSYGG QPGSTAAPTP YGAYNGPVPG YQQTPPPGVS
RAPASSGAPP ASTAQGPCGQ TAYGQFGQGD VQNGPSSGVQ MQRLPGSQPF ASAPLAPVVS
QPAVLQPYGP PPTSAQVTAQ LAGMQISGAV APAPPASGLG YGSPTSLASA SGSFPNSGLY
GSYPQGQAPP LGQGHPGAQP PQRSVPPQAS SFTPPASGGP RMPSMTGPLL PGQSFGGPPV
SQPNHVSSPP PQALPPGTQM TGPPGPPPPM HSSQQPGYQL QQNGSFGPAR GPQSNYGSPY
PGAATFGSQP GPPQPLPPKR LDPDAIPSPQ LNELPPQQKT RHRIDPDAIP SPIQVIEDDR
NNRGSEPFVT GVRGQVPPLV TTNFLVKDQG NASPRYIRCT SYNIPCTSDM AKQAQVPLAA
VIKPLARLPP EEASPYVVDH GESGPLRCNR CKAYMCPFMQ FVEGGRRFQC CFCSCINDVP
PQYFQHLDHT GKRVDAYDRP ELSLGSYEFL ATVDYCKNNK FPIPPAFIFM IDVSYNAVRS
GLVRLLCEEL KSLLDFLPRE GGAEESAIRV GFVTYNKVLH FYNVKSSLAQ PQMMVVSDVG
DMFVPLLDGF LVNVSESRAV ITSLLDQIPE MFADTRETET VFAPVVQAGM EALKAAECAG
KLFLFHTSLP IAEAPGKLKN RDDRKLINTD KEKTLFQPQS GAYQTLAKEC VAQGCCVDLF
LFPNQYVDVA TLSVVPQLTG GSVYKYACFQ VENDQERFLS DLRRDVQKVV GFDAVMRVRT
STGIRAVDFF GAFYMSNTTD VELAGLDGDK TVTVEFKHDD RLNEENGALL QCALLYTSCA
GQRRLRIHNL ALNCCTQLAD LYRNCETDTL INYMAKFAYR GVLSSPVKTV RDTLITQCAQ
ILACYRKNCA SPSSAGQLIL PECMKLLPVY LNCVLKSEVL QPGAEVTTDD RAYVRQLVTS
MDVAETNVFF YPRLLPLTKS PIENTTEPPA VRASEERLSN GDIYLLENGL NLFLWVGASV
QQGVVQSLFG VSSFSQITSG LSVLPVLDNL LSKKVRGLID SLRAQRSRYM KLIVVKQEDK
LEMLFKHFLV EDKSLSGGAS YVDFLCHMHK EIRQLLS
//
