ID E1BJH6_BOVIN Unreviewed; 129 AA.
AC E1BJH6; A0A8J8YA27; M5FI47;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Fn14 {ECO:0000313|EMBL:ADW27169.1};
DE SubName: Full=TNF receptor superfamily member 12A {ECO:0000313|Ensembl:ENSBTAP00000016020.5};
DE SubName: Full=Tumor necrosis factor receptor superfamily, member 12A-like {ECO:0000313|EMBL:DAA15711.1};
GN Name=TNFRSF12A {ECO:0000313|EMBL:DAA15711.1,
GN ECO:0000313|Ensembl:ENSBTAP00000016020.5,
GN ECO:0000313|VGNC:VGNC:36162};
GN ORFNames=BOS_22618 {ECO:0000313|EMBL:DAA15711.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000016020.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|EMBL:DAA15711.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2] {ECO:0000313|EMBL:ADW27169.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang J.-X., Zhang S.-Q., Sang M.;
RT "The characterization of cattle tumor necrosis factor receptor superfamily,
RT member 12a (Fn14).";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ADW27169.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21955444; DOI=10.1016/j.vetimm.2011.09.002;
RA Zhang J.X., Sang M., Li J.F., Zhao W., Ma H.W., Min C., Hu Y.L., Du M.X.,
RA Zhang S.Q.;
RT "Molecular structure and characterization of the cytokine TWEAK and its
RT receptor Fn14 in bovine.";
RL Vet. Immunol. Immunopathol. 144:238-246(2011).
RN [4] {ECO:0000313|Ensembl:ENSBTAP00000016020.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016020.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSBTAP00000016020.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016020.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GU594280; ADW27169.1; -; mRNA.
DR EMBL; GJ062847; DAA15711.1; -; Genomic_DNA.
DR RefSeq; NP_001193256.1; NM_001206327.1.
DR PaxDb; 9913-ENSBTAP00000016020; -.
DR Ensembl; ENSBTAT00000016020.6; ENSBTAP00000016020.5; ENSBTAG00000012082.6.
DR GeneID; 617439; -.
DR KEGG; bta:617439; -.
DR CTD; 51330; -.
DR VEuPathDB; HostDB:ENSBTAG00000012082; -.
DR VGNC; VGNC:36162; TNFRSF12A.
DR eggNOG; ENOG502SFZC; Eukaryota.
DR GeneTree; ENSGT00390000001948; -.
DR HOGENOM; CLU_164863_0_0_1; -.
DR OMA; HSDFCRG; -.
DR OrthoDB; 4612315at2759; -.
DR TreeFam; TF337901; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000012082; Expressed in gluteus medius and 104 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 4.10.400.20; -; 1.
DR InterPro; IPR022316; TNFR_12.
DR PANTHER; PTHR32037; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 12A; 1.
DR PANTHER; PTHR32037:SF2; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 12A; 1.
DR Pfam; PF12191; stn_TNFRSF12A; 1.
DR PRINTS; PR01962; TNFACTORR12.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:DAA15711.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..129
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035148651"
FT TRANSMEM 78..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 129 AA; 13728 MW; A9AEB1A940E8EDDF CRC64;
MAPCPLRPLL RLLVLGLGLA LLRAAAGERV PGTTPCSRGT SWSADLDKCM DCASCRARPH
SDFCLGCTAA PPAPFRLLWP ILGGALGLAL VLGLLSGFLV WRRCRRREKF TTPIEETGGE
SCPGVALIQ
//
