ID E1BJL1_BOVIN Unreviewed; 427 AA.
AC E1BJL1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Receptor associated protein of the synapse {ECO:0000313|Ensembl:ENSBTAP00000028986.6};
GN Name=RAPSN {ECO:0000313|Ensembl:ENSBTAP00000028986.6,
GN ECO:0000313|VGNC:VGNC:33728};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000028986.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000028986.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028986.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000028986.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028986.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPsyn family.
CC {ECO:0000256|ARBA:ARBA00007295}.
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DR RefSeq; XP_010811158.1; XM_010812856.2.
DR AlphaFoldDB; E1BJL1; -.
DR SMR; E1BJL1; -.
DR STRING; 9913.ENSBTAP00000028986; -.
DR PaxDb; 9913-ENSBTAP00000028986; -.
DR Ensembl; ENSBTAT00000028986.6; ENSBTAP00000028986.6; ENSBTAG00000021745.6.
DR GeneID; 541061; -.
DR CTD; 5913; -.
DR VEuPathDB; HostDB:ENSBTAG00000021745; -.
DR VGNC; VGNC:33728; RAPSN.
DR eggNOG; KOG1941; Eukaryota.
DR GeneTree; ENSGT00390000016785; -.
DR HOGENOM; CLU_030911_0_0_1; -.
DR InParanoid; E1BJL1; -.
DR OMA; ALRCSHI; -.
DR OrthoDB; 893642at2759; -.
DR TreeFam; TF328344; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000021745; Expressed in laryngeal cartilage and 70 other cell types or tissues.
DR ExpressionAtlas; E1BJL1; baseline.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0099634; C:postsynaptic specialization membrane; IEA:Ensembl.
DR GO; GO:0033130; F:acetylcholine receptor binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR GO; GO:0098879; F:structural constituent of postsynaptic specialization; IEA:Ensembl.
DR GO; GO:0097049; P:motor neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0099645; P:neurotransmitter receptor localization to postsynaptic specialization membrane; IEA:Ensembl.
DR GO; GO:2000673; P:positive regulation of motor neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1900075; P:positive regulation of neuromuscular synaptic transmission; IBA:GO_Central.
DR GO; GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IEA:Ensembl.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
DR CDD; cd16478; RING-H2_Rapsyn; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001237; Postsynaptic.
DR InterPro; IPR018293; Postsynaptic_CS.
DR InterPro; IPR019568; Rapsyn_myristoylation/link_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46574; 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE; 1.
DR PANTHER; PTHR46574:SF1; 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE; 1.
DR Pfam; PF10579; Rapsyn_N; 1.
DR Pfam; PF17874; TPR_MalT; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR PRINTS; PR00217; POSTSYNAPTIC.
DR SMART; SM00184; RING; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS00405; 43_KD_POSTSYNAPTIC; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 123..156
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 378..418
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 427 AA; 48085 MW; CF9A5A200356BB37 CRC64;
MGQDQTKQQI EKGLQLYQSN QTEKALQLWM KVLEKSSDLV GRFRVLGCLV TAHSEMGRYK
EMLKFAVVQI DTARELEDAN FLLESYLNLA RSNEKLCEFH KTISYCKTCL GLPGTRAAAQ
LGGQVSLSMG NAFLGLSLFQ KALESFEKAL RYAHNNDDAM LECRVCCSLG SFYAQVKDYE
KALFFPCKAA ELVNDYGKGW SLKYRAMSQY HMAVAYRLLG HLGSAMECCE ESMKIALQHG
DRPLQALCLL CFADIHRSRG DLQTAFPRYD SAMSIMTEIG NRLGQVQVLL GVAKCWVARK
ALDKALDAIE RAQDLAEEVG NKVRPDSVCW VWSQEPKLGQ LKLHCLSEGI YRSKGLQREL
RAHVVRFHEC VEEAELYCGL CGESIGEKNS RLQALPCSHI FHLRCLQNNG TRSCPNCRRS
SMKPGFV
//
