ID E1BKN5_BOVIN Unreviewed; 176 AA.
AC E1BKN5;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Interleukin family protein {ECO:0000256|RuleBase:RU368043};
GN Name=IL20 {ECO:0000313|Ensembl:ENSBTAP00000003574.2,
GN ECO:0000313|VGNC:VGNC:30138};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000003574.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000003574.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003574.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000003574.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003574.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Immune regulatory cytokine. {ECO:0000256|RuleBase:RU368043}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU368043}.
CC -!- SIMILARITY: Belongs to the IL-10 family.
CC {ECO:0000256|ARBA:ARBA00008813, ECO:0000256|RuleBase:RU368043}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; E1BKN5; -.
DR SMR; E1BKN5; -.
DR STRING; 9913.ENSBTAP00000003574; -.
DR PaxDb; 9913-ENSBTAP00000003574; -.
DR Ensembl; ENSBTAT00000003574.3; ENSBTAP00000003574.2; ENSBTAG00000002757.3.
DR VEuPathDB; HostDB:ENSBTAG00000002757; -.
DR VGNC; VGNC:30138; IL20.
DR eggNOG; ENOG502S5RZ; Eukaryota.
DR GeneTree; ENSGT00950000183124; -.
DR HOGENOM; CLU_098690_0_0_1; -.
DR InParanoid; E1BKN5; -.
DR OMA; LQATESC; -.
DR TreeFam; TF333253; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000002757; Expressed in zone of skin and 7 other cell types or tissues.
DR ExpressionAtlas; E1BKN5; baseline.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045517; F:interleukin-20 receptor binding; IEA:Ensembl.
DR GO; GO:0045518; F:interleukin-22 receptor binding; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0031328; P:positive regulation of cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR020423; IL-10_CS.
DR InterPro; IPR020444; IL-24.
DR PANTHER; PTHR48394; INTERLEUKIN-19-RELATED; 1.
DR PANTHER; PTHR48394:SF4; INTERLEUKIN-20; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01937; INTRLEUKIN24.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU368043};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR620443-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU368043};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU368043}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT CHAIN 25..176
FT /note="Interleukin family protein"
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT /id="PRO_5031592081"
FT DISULFID 33..126
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 80..134
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 80..132
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-51"
FT DISULFID 81..134
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-51"
SQ SEQUENCE 176 AA; 19938 MW; EA502ECB39A236D1 CRC64;
MRGSGLPLCL LSAVFYLFWT PSAGLKTLHL GSCVITTNLQ GIRSGFSEIR DSVQAKDEII
DVRILRKTQS LQGTKPADQC CLLHHILRLY LDRVFKNYQP PDHHIFRKVS RLANSLLTIK
KDLQLCHAHM SCPCGEEAKE KYSQILSHFE ELPPQAVVVK ALGELDILLQ WMEEAD
//
