ID E1BKT2_BOVIN Unreviewed; 556 AA.
AC E1BKT2;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=TOX high mobility group box family member 3 {ECO:0000313|Ensembl:ENSBTAP00000000539.3};
GN Name=TOX3 {ECO:0000313|Ensembl:ENSBTAP00000000539.3,
GN ECO:0000313|VGNC:VGNC:36229};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000000539.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000000539.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000539.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000000539.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000539.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_002694823.1; XM_002694777.5.
DR RefSeq; XP_885168.3; XM_880075.8.
DR AlphaFoldDB; E1BKT2; -.
DR SMR; E1BKT2; -.
DR STRING; 9913.ENSBTAP00000000539; -.
DR PaxDb; 9913-ENSBTAP00000000539; -.
DR Ensembl; ENSBTAT00000000539.4; ENSBTAP00000000539.3; ENSBTAG00000000418.5.
DR GeneID; 539135; -.
DR KEGG; bta:539135; -.
DR CTD; 27324; -.
DR VEuPathDB; HostDB:ENSBTAG00000000418; -.
DR VGNC; VGNC:36229; TOX3.
DR eggNOG; KOG0381; Eukaryota.
DR GeneTree; ENSGT00940000158043; -.
DR HOGENOM; CLU_030650_1_0_1; -.
DR InParanoid; E1BKT2; -.
DR OMA; YYAYSKF; -.
DR OrthoDB; 4252846at2759; -.
DR TreeFam; TF106481; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000000418; Expressed in oocyte and 70 other cell types or tissues.
DR ExpressionAtlas; E1BKT2; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR GO; GO:0051219; F:phosphoprotein binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd21995; HMG-box_TOX-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45781; AGAP000281-PA; 1.
DR PANTHER; PTHR45781:SF3; TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 3; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 255..323
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 255..323
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 189..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 432..471
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 189..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 60639 MW; 0E27DC5D0387A0C8 CRC64;
MDVRFYPAAA GDPAGLDFAQ CLGYYGYSKF GNNNNYMNMA EANNAFFAAS EQTFHTPSLG
DEEFEIPPIT PPPESDPALG MPDVLLPFQG LSDPLPSQGS EFTPQFPPQS LDLPSITISR
NLVEQDGVLH SSGLHMDQSH TQVSQYRQDP SVIMRSIVHM TDAARSGIMP PAQLTTINQS
QLSAQLGLNL GGASVPHTSP SPPASKSATP SPSSSINEED ADETNRAIGE KRAAPDSGKK
PKTPKKKKKK DPNEPQKPVS AYALFFRDTQ AAIKGQNPNA TFGEVSKIVA SMWDSLGEEQ
KQVYKRKTEA AKKEYLKALA AYRASLVSKA AAESAEAQTI RSVQQTLAST NLTSSLLLNP
PLSQHGTVSA SPQTLQPSLP RSIAPKPLTM RLPVNPMVTS VTIAANMPSN LGAPLISSMV
GSASSAQVSP SVQTQQQQQQ QQMQQLQQQQ LQQQQLQQQQ LQQQLQQQHF QHHVQLQQQQ
LQQHINQQQL QQRLQLQQLQ HMQHQSQPSP RQHSPVTSQI TSPIPALGSP QPASQQHPSQ
IQSQTQTQVL SQVSIF
//
