ID E1BKY0_BOVIN Unreviewed; 1041 AA.
AC E1BKY0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Zinc finger protein 197 {ECO:0000313|Ensembl:ENSBTAP00000051224.2};
GN Name=ZNF197 {ECO:0000313|Ensembl:ENSBTAP00000051224.2,
GN ECO:0000313|VGNC:VGNC:54516};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000051224.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000051224.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000051224.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000051224.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000051224.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
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DR RefSeq; NP_001193742.1; NM_001206813.1.
DR RefSeq; XP_015314908.1; XM_015459422.1.
DR AlphaFoldDB; E1BKY0; -.
DR SMR; E1BKY0; -.
DR STRING; 9913.ENSBTAP00000051224; -.
DR PaxDb; 9913-ENSBTAP00000051224; -.
DR Ensembl; ENSBTAT00000055475.2; ENSBTAP00000051224.2; ENSBTAG00000037803.2.
DR GeneID; 515564; -.
DR KEGG; bta:515564; -.
DR CTD; 10168; -.
DR VEuPathDB; HostDB:ENSBTAG00000037803; -.
DR VGNC; VGNC:54516; ZNF197.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162801; -.
DR HOGENOM; CLU_002678_88_0_1; -.
DR InParanoid; E1BKY0; -.
DR OMA; TVEEFSW; -.
DR OrthoDB; 5306752at2759; -.
DR TreeFam; TF350837; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000037803; Expressed in oocyte and 108 other cell types or tissues.
DR ExpressionAtlas; E1BKY0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 23.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24384; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR PANTHER; PTHR24384:SF218; SI:DKEY-15H8.11 PROTEIN-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 20.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 22.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 12.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 22.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 22.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 45..127
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT DOMAIN 221..309
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 373..400
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 401..428
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 429..456
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 457..484
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 485..512
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 513..540
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 541..568
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 569..596
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 597..624
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 625..652
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 653..680
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 681..708
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 709..736
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 737..764
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 765..792
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 793..820
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 821..848
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 849..876
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 877..904
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 905..932
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 933..960
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 961..988
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 1041 AA; 120797 MW; 90872EE2A4E434F4 CRC64;
MATMTRENWA HNALRQEGLV KGKDDTWKWG TSFQGSSSTV WETSHLHFRQ LRYHETSGPQ
EALSRLRELC RRWLRPEART KAQILELLVL EQFLSILPGE IRTWVQIHRP GSGEEAVALV
EELQKDLDGP TLKVPAFVQD QDTLQEGLST PGIALPHAPT GSHISAEIRS NSLTDPVVFG
LLQDPQHDSP APEASALSQE ENPRNQLMAL MLLTAQPQEL VMFEEVSVCF TSEEWACLSP
VQRALYWDVM LENYGNVTSL EWETMTENEE VTSKLNISQR ADSQRGISKR FQGGVPYLLD
FEEECEWQIF SSQWRNEARE RDTLKKGSLC ERDKKKRTPP EKRGQKWKEF EESLASDSAF
SESLIGAEGK KLYKCDMCYK HFNKISHLIN HRRIHTGEKP HKCKECGKGF IQRSSLLMHL
RNHSGEKPYK CNECGKAFSQ SAYLLNHQRI HTGEKPYKCK ECGKGFYRHS GLIIHLRRHS
GERPYKCNEC GKVFSQNAYL IDHQRLHKGE EPYKCNKCQK AFILKKSLIL HQRIHSGEKP
YKCDECGKTF AQTTYLVDHQ RLHSTENPYK CKECGKVFIR SKSLLLHQRV HTEKKTFGCK
KCGKIFTSKS SLIDHKRMHS REKPYKCTEC GKAFTQSAYL FDHQRLHNGE KPYECNECGK
VFILKKSLIL HQRFHTGENL YECKDCGKVF GSNRNLIDHE RLHNGEKPYE CRECGKTFIM
SKSFMVHQKL HTQEKAYKCE DCGKAFSYNS SLLVHRRIHT GEKPFECNEC GRAFSSNRNL
IEHKRIHSGE KPYECNECGK CFILKKSLIG HQRIHTREKS YKCNDCGKVF SYRSNLIAHQ
RIHTGEKPYA CNECGKGFTY NRNLIEHQRI HSGEKTYECH VCRKVLTSSR NLMVHQRIHT
GEKPYKCSEC GKDFSQNKNL VVHQRMHTGE KPYECEKCRK SFTSKRNLVG HQRIHTGEKP
YGCNDCNKVF RQRKNLTVHQ KIHTDEKNCE CDESEKEFSQ TSNLHLQPKI HSLEDFRSYS
LGSKFSWVQN ANESKIKIQK I
//
