ID E1BKZ0_BOVIN Unreviewed; 3085 AA.
AC E1BKZ0;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Pericentrin {ECO:0000313|Ensembl:ENSBTAP00000029328.6};
GN Name=PCNT {ECO:0000313|Ensembl:ENSBTAP00000029328.6,
GN ECO:0000313|VGNC:VGNC:32637};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000029328.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000029328.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029328.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000029328.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029328.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR Ensembl; ENSBTAT00000029328.6; ENSBTAP00000029328.6; ENSBTAG00000030670.4.
DR VEuPathDB; HostDB:ENSBTAG00000030670; -.
DR VGNC; VGNC:32637; PCNT.
DR eggNOG; ENOG502QV16; Eukaryota.
DR GeneTree; ENSGT00730000110871; -.
DR HOGENOM; CLU_000160_0_0_1; -.
DR TreeFam; TF336114; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000030670; Expressed in choroid plexus and 113 other cell types or tissues.
DR ExpressionAtlas; E1BKZ0; baseline and differential.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005814; C:centriole; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR GO; GO:0090316; P:positive regulation of intracellular protein transport; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR028745; AKAP9/Pericentrin.
DR InterPro; IPR019528; PACT_domain.
DR PANTHER; PTHR44981:SF3; PERICENTRIN; 1.
DR PANTHER; PTHR44981; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR Pfam; PF10495; PACT_coil_coil; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 2889..2968
FT /note="Pericentrin/AKAP-450 centrosomal targeting"
FT /evidence="ECO:0000259|Pfam:PF10495"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2163..2217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2283..2303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2849..2873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2977..3053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 130..246
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 287..450
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 540..632
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 935..997
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1503..1544
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1576..1614
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1655..1700
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1731..1793
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2431..2713
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2997..3018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3020..3034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3035..3050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3085 AA; 348963 MW; 3AE18ED7B00DF8C3 CRC64;
MEDDEQEQRR RKVEAGRAKL AHFRQRKTKG DCTHSKKTPA KRKGTTVNAP VTEESPVAAP
GNTGPLGGLD IGKNPTCSDT PDGAEAAQLQ EPSRERTPPK LDGHCAEQPG VMTKELELEV
LRLSLSDMHA ARLERTQAHL QREKEAALAE LHAELTGRHA QERALLQSRA RRELELVREE
AAELKEKLQS EIEKNAQMME ILKQDWESER DSCLENLRQE LLEKHRSELE NLQNQFKKEL
AQQKAEFEKV FQAKNQAECS LQTQEAQHEA SLSKLRADLQ LEHCQYLEEL ERKFRKKEKE
NQLELERLRA SYEELQAQSR EEIQCLGAQL ESARSSRQEL SELREQLLAR ASHVEELELL
KRDLEQQQQQ ERSRHESELE QLRLYFEEKL REAEQSYQED LTLLQRRLQE GRDDSLLEAM
GTSACLEETS EEERDHLNGL SLQREQLEES LGLRTRLEEN HQCQLAAGTS SQDAQQEALE
GELPTGPSEE PGQELAREPL LCAQSVALEL ETEVQAGDMG LETAHRAQLV LLPVELKKEI
DLLKVENRNL QEKLQREICL KEDLEKVKQN LVEAHQEELK SAEERIEQIK QELREREAEW
KVTSEDLRRG AEEKLTKMLL DLREQVESEK RSMMNRFELR ESEMRQLQDQ QAAQILDLEG
SLVEQQGRLR QLELGLTGDE SLRCSHCGRE LGCSPAPGAQ DQELAILHLK EDCALQLKVA
QSRFLEERRA ITEKLAAEQD AFLREAQEQH AHELRLLQEG HQRHILSLTA ELETRHQAEV
DALRSSLERE RLALAEAREA ELQVKHAADI NVLEARHASH LDALRLQYLS ELQAVQGRHR
QALELLRLDL EERLQKEDMA HHAVLTQVLE LLELRCAEEP QPAEDSLRGD GSVEPQEGVR
AVRLSMAHKG EFGSERKAAL HGKEEIHKLD HEKAHSLYEK EKESLSLQLQ EKNNQILQLK
DQILSLNREV EERHSELEKL QERRERENQE GTALIAMLKS DVDLSHGERR ALQDTLRRLL
GLFGETLQTA IALKSRIGER VGLCLEDRSP PTTQPGGQSP PTDPALDDMW AGLDVASLEP
DGTVAECAET SSVAEISSHV CESFFLSPER TLDCEQPVRR VFQSLGLAVD GLLEMVLDSA
RQLEEARQIH SRFEKEFSCK NEETAQVVRK HQELLEQLEA ESKAKAQLAL ELHKAEGIIE
GFKEEKAGLQ EALGQKEASE RGLVGELEGL RQQLQRAARR QAELREENAA LCSQTEALAA
DAREREAALR REVESLTQEQ SEARRQADKD RASLLSQMRF LEAELEEQLS HQQACARQAE
ELAALRQQID SLDQHLRRQR QFMDEQAVER EREREDFQQE IQRLEEQLRQ AARPRSPGLR
DSHRAQLDKE VELLEEKLRE KSDGLNELIL KKELVDRQVL IQGEEIRRLE ETNASTTRKL
LQLQEELETQ RRAVRALQQD KEALQEQQMS NLLQVSALQS RLDEGKCPVP PEGGRPDRAE
AQLEAMQGAL RQREAEVSDI KEQLENLKDD LVNKNEEILH LNWKLGLQDN STAASIKELQ
EENAHLKVVC NRSSEVEELK SIIETLRENQ ARLQKDNAEE IEQLHEVIEK LQRELPLGGP
EAPKAGEGGA MSLQSELLGL PAEGAEAPAV LAGELHAALE AKEALSQRLA EQERQHSQAL
EALQQRLQAA EEAATRQLAE LQPEGVASQI REFEAALHAR EAKIAERDLE IQALRREKST
HSAELEAILA AVARFRHALE QQLLAASGEP PELQRLREQC VCLSRQLQAL NQRFLKCQKE
LDERQACGEG GSQGWVPRGK ETSCSEELQQ DVDGRQLAQA LDSRGSDPQS LVKDDLQPAK
ALPTLTCARP SQQDSVISVL TVCQQQLESE LLLVKKEMRL HAEDGGRASG AVKDKGKLLE
DCRLQKVDLI AQVKQLQEKL NHLVCSMSFQ NIEMEDFKYQ QALASPCALE DGLSDGSDNS
EETDKSPPID TFNIIWDLAE VTGNSDSLIR NEPDAPTGEQ VTLQDRSLCL QSHLHGCSQD
LTHSQGSKPL KNVLRTMGLS PWSSPEVVRE DSTLEPLPNL PLTPCSDALS LHSLDTSLWD
GTSTHVLQAD QSGRLCYPGE SAAGTAPKWV GSPLAADGVP SANHHAQRVP VEKDVEDFII
TSLDSQEKSR SPPLGLEGKS DGKSGGVEFA EPLSQGSGRL GAPTASPAAP PVTPRDCRRP
LDTMKEKEVH PKQVKALLQM VCDESHHILA LSEYREPPHI LSRSEPSARL ECLPLGGQGL
LEAVPAPREH PTPGSQKGEK ASSNVGLDWK GDFLQTVQEA FEKEWEMLRV ELWPQLCGLG
PGGCGSLLER LEKVVHEQGD QQERSLEHLC LSDRSSLLSE IQALRAQLRM THLQNQEKLQ
QLCTALTSAE ARGSRQEHRL RRQVELLAYK VEQEKCIASD LQKTLNEEQE KANNVRKLLV
AEQNAVRDLK SELCECRQDN ERLLKSLNDV QKEVLQLRSM LDSKESDLQA ALQHLEGERM
KEQALQSQLE EERLQHMQRE GQSAKTLEEL RASLEQQCAQ SNQLCVVLKH EQTAKDNLRQ
ELQIEASRCE ALLAQERGHM SELQRSLEAE RDRARELSEA LQHERILTER LSRRPQERPA
HQALLQKLRA QEEHVRELEV ALEAAQRRAL EAEAHVHREE VEREQERELE LQRQRDEHKI
QQLQRTVQEL QARVALPNTE PEHLREQQRG LEKVRQQLLC AAGLLTSFIN QTVDRTISDW
TSSNEKAVAS LLHTLETLKS ELGTSSSCRK KTAAELQIQL VDVLLKDNES LSRALSTVTR
EKAELCKALS RLERAHRVPR TLQEGCARKR SDRSAWKQDK MVSPGSARHP DPALDAGACS
AKMEKLYLRY LRAESFRKAL IYQKKYLLLL IGGFQDSEQE TLSMIAHLGV FPSKADKKAA
GPRPLTRFRT AVRVVIAVLR LRFLVKKWQQ VDGRGALAPG QALRPGEGFL VPRRQQSPPV
TRESPPTRDV SSSQARDPVP KASPRRREKS SPPSNPRSER SLTASQDPEH SLTEYIHHLE
MIQQRLGGVL PDSTSKKSCC QKMKQ
//
