ID E1BLX8_BOVIN Unreviewed; 290 AA.
AC E1BLX8;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta {ECO:0000256|RuleBase:RU362099};
GN Name=ATP4B {ECO:0000313|Ensembl:ENSBTAP00000026587.4,
GN ECO:0000313|VGNC:VGNC:26298};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000026587.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000026587.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026587.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000026587.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026587.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC which catalyzes the hydrolysis of ATP coupled with the exchange of
CC Na(+) and K(+) ions across the plasma membrane.
CC {ECO:0000256|RuleBase:RU362099}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000256|ARBA:ARBA00005876, ECO:0000256|RuleBase:RU362099}.
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DR RefSeq; NP_001193069.1; NM_001206140.1.
DR AlphaFoldDB; E1BLX8; -.
DR SMR; E1BLX8; -.
DR STRING; 9913.ENSBTAP00000026587; -.
DR PaxDb; 9913-ENSBTAP00000026587; -.
DR Ensembl; ENSBTAT00000026587.5; ENSBTAP00000026587.4; ENSBTAG00000019961.5.
DR GeneID; 614308; -.
DR KEGG; bta:614308; -.
DR CTD; 496; -.
DR VEuPathDB; HostDB:ENSBTAG00000019961; -.
DR VGNC; VGNC:26298; ATP4B.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT01030000234579; -.
DR HOGENOM; CLU_057702_1_1_1; -.
DR InParanoid; E1BLX8; -.
DR OMA; TAPRVNC; -.
DR OrthoDB; 2880589at2759; -.
DR TreeFam; TF314618; -.
DR Reactome; R-BTA-936837; Ion transport by P-type ATPases.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000019961; Expressed in urinary bladder and 32 other cell types or tissues.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IBA:GO_Central.
DR GO; GO:0001671; F:ATPase activator activity; IBA:GO_Central.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1660; Na, k-atpase alpha subunit; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR NCBIfam; TIGR01107; Na_K_ATPase_bet; 1.
DR PANTHER; PTHR11523:SF11; POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA; 1.
DR PANTHER; PTHR11523; SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
DR PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
PE 3: Inferred from homology;
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781};
KW Ion transport {ECO:0000256|RuleBase:RU362099};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362099};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362099};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362099}; Transport {ECO:0000256|RuleBase:RU362099}.
FT TRANSMEM 37..63
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362099"
SQ SEQUENCE 290 AA; 33251 MW; 69ED1EBEE82F4C83 CRC64;
MAALQEKKSC GQRMEEFRRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV MTGIFALCIY
VLMCTIDPYT PDYQDQLKSP GVTLRPDTYG DKGLDISYNV SDNRTWTGLT QALRHFLAGY
SPAAQEDNIN CTSERYFFQE RFLAPNHTKF SCKFTADMLQ NCSGQPDPTF GFAEGKPCFI
IKMNRIVKFL PGNSTAPRVD CAFLDQHRDA PALQVEYFPP NGSYSLHYFP YYGKKAQPHY
SNPLVAAKLL NVPKNKEVVV VCKILAEHVT FDNPHDPYEG KVEFKLTIQK
//
