ID E1BMG7_BOVIN Unreviewed; 2465 AA.
AC E1BMG7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Teneurin transmembrane protein 3 {ECO:0000313|Ensembl:ENSBTAP00000053210.3};
GN Name=TENM3 {ECO:0000313|Ensembl:ENSBTAP00000053210.3,
GN ECO:0000313|VGNC:VGNC:35743};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000053210.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000053210.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053210.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000053210.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053210.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSBTAT00000061514.3; ENSBTAP00000053210.3; ENSBTAG00000021133.7.
DR VEuPathDB; HostDB:ENSBTAG00000021133; -.
DR VGNC; VGNC:35743; TENM3.
DR eggNOG; KOG4659; Eukaryota.
DR GeneTree; ENSGT01030000234566; -.
DR HOGENOM; CLU_000229_0_0_1; -.
DR TreeFam; TF316833; -.
DR Proteomes; UP000009136; Chromosome 27.
DR Bgee; ENSBTAG00000021133; Expressed in adenohypophysis and 95 other cell types or tissues.
DR ExpressionAtlas; E1BMG7; baseline and differential.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF65; TENEURIN-3; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 75..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..75
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 376..408
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 410..443
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 505..540
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 398..407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 433..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 509..519
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 530..539
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2465 AA; 274904 MW; 13B8B3D0AF0CCC43 CRC64;
MDRFLPNLKP NVLYRKHFLF KTGTGTTPLF STATPGYTMA SGSVYSPPTR PLPRNTLSRS
AFKFKKSSKY CSWKCTALCA VGVSVLLAIL LSYFIAMHLF GLNWQLQQTE NDTFENGKVN
SDTMPTNTVS LPSGDNGKLG GFTQENNTID SGELDIGRRA IQEVPPGIFW RSQLFIDQPQ
FLKFNISLQK DALIGVYGRK GLPPSHTQYD FVELLDGSRL IAREQRNLLE SERAGRQARS
VSLHEAGFIQ YLDSGIWHLA FYNDGKNAEQ VSFNTIVIES VVECPRNCHG NGECVSGTCH
CFPGFLGPDC SRAACPVLCS GNGQYSKGRC LCFSGWKGTE CDVPTTQCID PQCGGRGICI
MGSCACNSGY KGENCEEADC LDPGCSNHGV CIHGECHCNP GWGGNNCEIL KTMCPDQCSG
HGTYLQESGS CTCDPNWTGP DCSNEICSVD CGSHGVCMGG SCRCEEGWTG PACNQRACHP
RCAEHGTCKD GKCECSQGWN GEHCTIEGCP GLCNSNGRCT LDQNGWHCVC QPGWRGAGCD
VAMETLCTDS KDNEGDGLID CMDPDCCLQS SCQNQPYCRG LPDPQDIISQ SLQSPSQQAA
KSFYDRISFL IGSDSTHVIP GESPFNKSLA SVIRGQVLTA DGTPLIGVNV SFFHYPEYGY
TITRQDGMFD LVANGGASLT LVFERSPFLT QYHTVWIPWN VFYVMDTLVM KKEENDIPSC
DLSGFVRPNP IIVSSPLSTF FRSSPEDSPI IPETQVLHEE TTIPGTDLKL SYLSSRAAGY
KSVLKITMTQ SVIPFNLMKV HLMVAVVGRL FQKWFPASPN LAYTFIWDKT DAYNQKVYGL
SEAVVSVGYE YESCLDLTLW EKRTAILQGY ELDASNMGGW TLNKHHVLDV QNGILYKGNG
ENQFISQQPP VVSSIMGNGR RRSISCPSCN GQADGNKLLA PVALACGIDG SLYVGDFNYV
RRIFPSGNVT SVLELSSNPA HRYYLATDPV TGDLYVSDTN TRRIYRPKSL TGAKDLTKNA
EVVAGTGEQC LPFDEARCGD GGKAVEATLM SPKGMAIDKN GLIYFVDGTM IRKVDQNGII
STLLGSNDLT SARPLTCDTS MHISQVRLEW PTDLAINPMD NSIYVLDNNV VLQITENRQV
RIAAGRPMHC QVPGVEYSAG KHAVQTTLES ATAIAVSYSG VLYITETDEK KINRIRQVTT
DGEISLVAGI PSECDCKNDA NCDCYQSGDG YAKDAKLSAP SSLAASPDGT LYIADLGNIR
IRAVSKNKPL LNSMNFYEVA SPTDQELYIF DINGTHQYTV SLVTGDYLYN FSYSNDNDIT
AVTDSNGNTL RIRRDPNRMP VRVVSPDNQV IWLTIGTNGC LKSMTAQGLE LVLFTYHGNS
GLLATKSDET GWTTFFDYDS EGRLTNVTFP TGVVTNLHGD MDKAITVGIE SSSREEDVSI
TSNLSSIDSF YTMVQDQLRN SYQIGYDGSL RIIYASGLDS HYHTEPHILA GTANPTVAKR
NMTLPGENGQ NLVEWRFRKE QAQGKVNVFG RKLRVNGRNL LSVDFDRTTK TEKIYDDHRK
FLLRIAYDTS GHPTLWLPSS KLMAVNVTYS STGQIASIQR GTTSEKVDYD GQGRIVSRVF
ADGKTWSYTY LEKSMVLLLH SQRQYIFEYD MWDQLSAITM PSVARHTMQT IRSIGYYRNI
YNPPESNASV ITDYNEEGLL LQTAFLGTSR RVLFKYRRQT RLSEILYDST RVSFTYDETA
GVLKTVNLQS DGFICTIRYR QIGPLIDRQI FRFSEDGMVN ARFDYSYDNS FRVTSMQGVI
NETPLPIDLY QFDDISGKVE QFGKFGVIYY DINQIISTAV MTYTKHFDAH GRIKEIQYEI
FRSLMYWITI QYDNMGRVTK REIKIGPFAN TTKYAYEYDV DGQLQTVYLN EKIMWRYNYD
LNGNLHLLNP SSSARLTPLR YDLRDRITRL GDVQYRLDED GFLRQRGTEI FEYSSKGLLT
RVYSKGSGWT VIYRYDGLGR RVSSKTSLGQ HLQFFYADLT YPTRITHVYN HSSSEITSLY
YDLQGHLFAM EISSGDEFYI ASDNTGTPLA VFSSNGLMLK QIQYTAYGEI YFDSNIDFQL
VIGFHGGLYD PLTKLIHFGE RDYDILAGRW TTPDIEIWKR IGKDPAPFNL YMFRNNNPAS
KIHDVKDYIT DVNSWLVTFG FHLHNAIPGF PVPKFDLTEP SYELVKSQQW DDVPPIFGVQ
QQVARQAKAF LSLGKMAEVQ VSRRKGSGAP SWLWFATVKS LIGKGVMLAV SQGRVQTNVL
NIANEDCIKV AAVLNNAFYL ENLHFTIEGK DTHYFIKTST PESDLGTLRL TSGRKALENG
INVTVSQSTT VVNGRTRRFA DVEMQFGALA LHVRYGMTLD EEKARILEQA RQRALARAWA
REQQRVRDGE EGARLWTEGE KRQLLSAGKV QGYDGYYVLS VEQYPELADS ANNIQFLRQS
EIGKR
//
