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Database: UniProt
Entry: E1BMQ7_BOVIN
LinkDB: E1BMQ7_BOVIN
Original site: E1BMQ7_BOVIN 
ID   E1BMQ7_BOVIN            Unreviewed;      1262 AA.
AC   E1BMQ7;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   12-SEP-2018, entry version 57.
DE   SubName: Full=Short transient receptor potential channel 2 homolog {ECO:0000313|Ensembl:ENSBTAP00000015344};
GN   Name=TRPC2 {ECO:0000313|Ensembl:ENSBTAP00000015344};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000015344, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000015344, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000015344,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000015344}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000015344};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS01006510}.
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DR   EMBL; DAAA02040996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_776902.3; NM_174477.4.
DR   UniGene; Bt.2872; -.
DR   Ensembl; ENSBTAT00000015344; ENSBTAP00000015344; ENSBTAG00000011549.
DR   GeneID; 282101; -.
DR   KEGG; bta:282101; -.
DR   CTD; 7221; -.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   KO; K04965; -.
DR   OMA; YFLDWWN; -.
DR   OrthoDB; EOG091G0KP0; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000011549; Expressed in 10 organ(s), highest expression level in testis.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0000012; P:single strand break repair; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005458; TRPC2_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   InterPro; IPR002706; Xrcc1_N.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF6; PTHR10117:SF6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   Pfam; PF01834; XRCC1_N; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01643; TRPCHANNEL2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    721    741       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    761    779       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    828    847       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    923    942       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    991   1012       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    149       XRCC1_N. {ECO:0000259|Pfam:PF01834}.
FT   DOMAIN      557    619       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      718   1022       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1131   1158       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1262 AA;  139913 MW;  44F8DB5F0D4EA727 CRC64;
     MAPVRISHVV SFSSQDPKYP VENLLNPDSQ RGPWLSCPQD KSGQLKVELQ LERAVPIGYI
     DVGNCGCAFL QIDVGRSSWS LDRPFVTLLP ATMLMSLADS KQGKNRSGVR MFKDADFLAP
     ASSESWDRLR LSCSQPFTRH QPFGLAFLRV CSSLDSLDDP VEGPSVPVSS GLSQGSSDAQ
     ESGPSPWLAN PSIRRTFFPD PQTTTKEISE LRNFLKQLQP GTLGRSACMV LSAAHRAPPA
     RVANPKTNHA EPGPAHQDST EPRTEEQNTE KDVGRAKRRK VGARRPVSNS NSRPNQRGLA
     KAGQREHLRP LARSSRVQES GWCPICAGSF SIDLLPQHAA TCGGASLPPP ASPASSPSSS
     PHVLRFRCVA LTPVPLVSRP QPNWTEIVNR KLKFPAPLLG AIQEGHTGLV QQLLEVGVEA
     PGGGPGGPPR NVEEAEDRSW REALNLAIRL GHEAITDVLL ANVKFDFRQI HEALLVAVDT
     NQPAVVRHLL ARLEREKGRK VDTRSSSLAF FDSSIDGSRF APGVTPLTLA CQKDLYEIAQ
     LLMGQGHTIA RPHPVSCACL ECSNARRYDL LKFSLSRINT YRGIASRAHL SLASEDAMLA
     AFQLSRELRH LARKEPEFKP EYIALESLSQ DYGFELLGMC RNQSEVTAVL NDLGEDSETE
     PEAEGLGQAF EEGIPNLARL RLAVNYNQKR FVAHPICQQV LSSIWCGNLA GWRGSTTIWK
     LFIAFLIFLT MPFLCLGYWL APKSRLGHLL KIPVLKFLLH SASYLWFLIF LLGESLVMET
     QLSTFRGRSQ SVWETSLHMV WVAGFLWFEC KEVWIEGLRS YLLDWWNFLD MVILSLYLAA
     FTLRLLLAGL AHKHCRDAPD GAACHYFTSA ERSEWRTEDP QFLAEVLFAV TSMLSFTRLA
     SILPAHESLG TLQISMGRMI DDMIRFMFIL MIILTAFLCG LNNIYVPYQE TERLGNFNET
     FQFLFWTMFG MEEHSVVDMP QFLVPEFVGR ALYGIFTIVM VIVLLNMLIA MITNSFQKIE
     DAADVEWKFA RSKLYLSYFR EGLTLPVPFN ILPSPKAIFY LLRRVFRFIC CCHLCCKTKK
     PDYPPIPTFA NPGAGAGPGE GERGSYRLRV IKALVQRYIE TAQREFEETR RKDLGNRLTE
     LTKTVSRLQS EVAGVQRAVV EAGPRRPPGG ASVLSRYITR VRNSFQNLGP PIPETPELTV
     PATVGTQESS ETGLPDAGGA QAPASGESGP SSPAHVLVHR EQESEGAGDL PQEADLGAKE
     GT
//
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