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Database: UniProt
Entry: E1BMU2_BOVIN
LinkDB: E1BMU2_BOVIN
Original site: E1BMU2_BOVIN 
ID   E1BMU2_BOVIN            Unreviewed;       388 AA.
AC   E1BMU2;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   24-JAN-2024, entry version 81.
DE   SubName: Full=Cytoglobin {ECO:0000313|Ensembl:ENSBTAP00000007304.5};
GN   Name=CYGB {ECO:0000313|Ensembl:ENSBTAP00000007304.5,
GN   ECO:0000313|VGNC:VGNC:50268};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000007304.5, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000007304.5, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007304.5,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000007304.5}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007304.5};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the globin family.
CC       {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238,
CC       ECO:0000256|RuleBase:RU000356}.
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DR   AlphaFoldDB; E1BMU2; -.
DR   SMR; E1BMU2; -.
DR   STRING; 9913.ENSBTAP00000007304; -.
DR   PaxDb; 9913-ENSBTAP00000007304; -.
DR   Ensembl; ENSBTAT00000007304.5; ENSBTAP00000007304.5; ENSBTAG00000005556.5.
DR   VEuPathDB; HostDB:ENSBTAG00000005556; -.
DR   VGNC; VGNC:50268; CYGB.
DR   eggNOG; KOG3378; Eukaryota.
DR   GeneTree; ENSGT00940000155004; -.
DR   HOGENOM; CLU_003827_10_1_1; -.
DR   InParanoid; E1BMU2; -.
DR   TreeFam; TF332967; -.
DR   Reactome; R-BTA-203615; eNOS activation.
DR   Reactome; R-BTA-8981607; Intracellular oxygen transport.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000005556; Expressed in pigment epithelium of eye and 99 other cell types or tissues.
DR   ExpressionAtlas; E1BMU2; baseline.
DR   GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08924; Cygb; 1.
DR   Gene3D; 1.10.490.10; Globins; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR013314; Globin_lamprey/hagfish.
DR   PANTHER; PTHR46783; CYTOGLOBIN; 1.
DR   PANTHER; PTHR46783:SF1; CYTOGLOBIN; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR01906; FISHGLOBIN.
DR   SUPFAM; SSF46458; Globin-like; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   3: Inferred from homology;
KW   Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PROSITE-ProRule:PRU00238};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PROSITE-ProRule:PRU00238};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00238};
KW   Oxygen transport {ECO:0000256|ARBA:ARBA00022621, ECO:0000256|PROSITE-
KW   ProRule:PRU00238}; Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW   ProRule:PRU00238}.
FT   DOMAIN          217..356
FT                   /note="Globin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS01033"
FT   REGION          1..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..70
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..187
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         279
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00238"
FT   BINDING         311
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   388 AA;  42217 MW;  473B8CFFA744BC0B CRC64;
     PPRRARGHAA NARECLTQSQ FPLAGRVHTR PQTRTSAAHS CAARAAPRPV TASPLLPGPP
     VPPPHLRPCP ARPSNSGLEG GQAPPASPPP RPSFTLPELA HGHGFGGLER IYFFSHFFQQ
     TTSPPPARGP PPPAHIPYTR AHTHTHTHTR RAQTDTLPPS GALYHSPPAA HAAGPGSPRP
     APRAPPSPSE AGLGLELLME KVPGEMEIER RERSEELSEA ERKAVQATWA RLYANCEDVG
     VAILVRFFVN FPSAKQYFSQ FKHMEEPLEM ERSPQLRKHA CRVMGALNTV VENLHDPEKV
     SSVLSLVGKA HALKHKVEPV YFKILSGVIL EVIAEEFAND FPPETQRAWA KLRGLIYSHV
     TAAYKEVGWV QQVPNATTPP ATLPSSGP
//
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