ID E1BMU2_BOVIN Unreviewed; 388 AA.
AC E1BMU2;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 24-JAN-2024, entry version 81.
DE SubName: Full=Cytoglobin {ECO:0000313|Ensembl:ENSBTAP00000007304.5};
GN Name=CYGB {ECO:0000313|Ensembl:ENSBTAP00000007304.5,
GN ECO:0000313|VGNC:VGNC:50268};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000007304.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000007304.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007304.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000007304.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000007304.5};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the globin family.
CC {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238,
CC ECO:0000256|RuleBase:RU000356}.
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DR AlphaFoldDB; E1BMU2; -.
DR SMR; E1BMU2; -.
DR STRING; 9913.ENSBTAP00000007304; -.
DR PaxDb; 9913-ENSBTAP00000007304; -.
DR Ensembl; ENSBTAT00000007304.5; ENSBTAP00000007304.5; ENSBTAG00000005556.5.
DR VEuPathDB; HostDB:ENSBTAG00000005556; -.
DR VGNC; VGNC:50268; CYGB.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000155004; -.
DR HOGENOM; CLU_003827_10_1_1; -.
DR InParanoid; E1BMU2; -.
DR TreeFam; TF332967; -.
DR Reactome; R-BTA-203615; eNOS activation.
DR Reactome; R-BTA-8981607; Intracellular oxygen transport.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000005556; Expressed in pigment epithelium of eye and 99 other cell types or tissues.
DR ExpressionAtlas; E1BMU2; baseline.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08924; Cygb; 1.
DR Gene3D; 1.10.490.10; Globins; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR013314; Globin_lamprey/hagfish.
DR PANTHER; PTHR46783; CYTOGLOBIN; 1.
DR PANTHER; PTHR46783:SF1; CYTOGLOBIN; 1.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR01906; FISHGLOBIN.
DR SUPFAM; SSF46458; Globin-like; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PROSITE-ProRule:PRU00238};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PROSITE-ProRule:PRU00238};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00238};
KW Oxygen transport {ECO:0000256|ARBA:ARBA00022621, ECO:0000256|PROSITE-
KW ProRule:PRU00238}; Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW ProRule:PRU00238}.
FT DOMAIN 217..356
FT /note="Globin family profile"
FT /evidence="ECO:0000259|PROSITE:PS01033"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..70
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 279
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00238"
FT BINDING 311
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 388 AA; 42217 MW; 473B8CFFA744BC0B CRC64;
PPRRARGHAA NARECLTQSQ FPLAGRVHTR PQTRTSAAHS CAARAAPRPV TASPLLPGPP
VPPPHLRPCP ARPSNSGLEG GQAPPASPPP RPSFTLPELA HGHGFGGLER IYFFSHFFQQ
TTSPPPARGP PPPAHIPYTR AHTHTHTHTR RAQTDTLPPS GALYHSPPAA HAAGPGSPRP
APRAPPSPSE AGLGLELLME KVPGEMEIER RERSEELSEA ERKAVQATWA RLYANCEDVG
VAILVRFFVN FPSAKQYFSQ FKHMEEPLEM ERSPQLRKHA CRVMGALNTV VENLHDPEKV
SSVLSLVGKA HALKHKVEPV YFKILSGVIL EVIAEEFAND FPPETQRAWA KLRGLIYSHV
TAAYKEVGWV QQVPNATTPP ATLPSSGP
//