ID E1BN52_BOVIN Unreviewed; 2180 AA.
AC E1BN52;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=FRAS1 related extracellular matrix 1 {ECO:0000313|Ensembl:ENSBTAP00000026827.4};
GN Name=FREM1 {ECO:0000313|Ensembl:ENSBTAP00000026827.4,
GN ECO:0000313|VGNC:VGNC:29110};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000026827.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000026827.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026827.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000026827.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000026827.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR RefSeq; NP_001179924.1; NM_001192995.1.
DR RefSeq; XP_005209978.1; XM_005209921.3.
DR RefSeq; XP_010806099.1; XM_010807797.2.
DR STRING; 9913.ENSBTAP00000026827; -.
DR PaxDb; 9913-ENSBTAP00000026827; -.
DR Ensembl; ENSBTAT00000026827.5; ENSBTAP00000026827.4; ENSBTAG00000020141.5.
DR GeneID; 508018; -.
DR KEGG; bta:508018; -.
DR CTD; 158326; -.
DR VEuPathDB; HostDB:ENSBTAG00000020141; -.
DR VGNC; VGNC:29110; FREM1.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000156990; -.
DR HOGENOM; CLU_001041_0_0_1; -.
DR InParanoid; E1BN52; -.
DR OMA; MAMFTLE; -.
DR OrthoDB; 5470912at2759; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000020141; Expressed in oocyte and 57 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0097094; P:craniofacial suture morphogenesis; IEA:Ensembl.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.40.2030; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF7; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 1.
DR Pfam; PF19309; Frem_N; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF141072; CalX-like; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2180
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003144185"
FT REPEAT 297..389
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 414..501
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 522..616
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 643..755
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 777..868
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 888..983
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1025..1127
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1148..1255
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1276..1373
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1394..1486
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1507..1597
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1629..1725
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 2061..2168
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 1974..2010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2180 AA; 244920 MW; 2B76D2A8B2796ADA CRC64;
MSSPSWGGLG ALLLLLLLPG WASPTFVRVN QGVRVMKGSS AFLSQDDLKF TIPKEKDACK
VEVVMNEPIT QRVGKLTPQV FDCHFLPNEV KYTHNGCPIL DEDTVKLRLY RFTETDTFTE
TFILRVYLLE PDCNIIRMSD NALEVSEFYG LSRVIDKNLL RFDYERMASL ECTVRLDPVG
THLPAHGQLV LVEPQLEEPR GDQPHSFFPE SQLGTELKCP GGRCTLGLKK VGSLKVSCEE
FLLMGLRYQH LGSPSPNIDY FSIQLDLTDS RSKISYKSES AWLPVYIRPG IPNQIPRAAF
MAMFILEVDQ FILTSLTTSV LDCEEDETPK PLLVFNITKA PLQGYVTHLW DHTRPVSSFT
WKDLRDMQIA YQPPNSSHSE RRLYEVELEV YDFFFEKSAP ITVHISIRTT DTNAPRVSWN
TGLNLLEGQS RAITWEQFQI VDNDDIHAVQ VVTVDGLQHG RLTVRGGKGF LFTVADLQAG
VVRYHHDDSD STKDFVVFRI FDSQHSIQHK FPINILPKDD SPPFLITNVV IELEEGQTIL
IQGSMLRASD MDSSDDYIFF NITKPPQAGE IMKKPAPGLI GYPVPGFIQR DLFNGIIYYR
HFGGEIFEDS FEFVLWDSHE PPNLSVPQVV TIHVTPVNDQ LPKEAPGVSR HLVVKETEVA
YITKKHLHFI DTESQDRELL YTITTPPFFS SSRRHLDAGK LFMVDSIPRL TKTPAAPGLK
YFTQHAVNHM KVAYMPPMQD VGPHPRHVQF AFSVSNQHGG TLYGICFNIT ILPVDNQAPK
VFTKPLRVAE GGQCVISTQH VLVSDEDTKL DNIYLSLQSP PQHGMVELNG FPLNKGTTFP
WGVLQALKLR YQHDGSEELQ DDIVLQVTDG TNTAEYVLHV EVFPVNDEPP VLKADLIPMM
HCSEGEEVVI TSEYIFATDV DSDDLKLIFM IVGEPQHGTV RRAGVTVHQF SQEDVVAGAV
TYKHTGGEIG LMPCFDTITL VVSDREAGPF VNGCCYNGPH PSVPLHESFP MYDLNITVYP
VDNQPPSVAI GTTFVVDEGF SAALTVNHLS ATDPDTAADD LEFVLVSPPQ FGYLENTLPS
AGFEKSNMGI SIASFQWKDM KALHINYVQS RHLGMEPTAD KFVLYVTDGK RRSMEIPFYI
IINATNDEAP DFIVQNITVC EGQMRELDSS IISATDRDIP KNPLLFSITH KPRHGLLINR
AFSRNFFQYK QLANPGQKHE LVYNFSMELL KNGMRLVYVH DDSESLADDF TIQVSDGKHK
ILKTIFVEVT PVNDEKPMLS KKAEITINMG ETRIISSAVL SAIDEDSPRE KIYYIFERIP
QNGQLQLKIG RDWVPLYPGM KCTQEEVDLN LLRYTHTGAM DSKNQDSFTF RLWDGDNRSP
AFDCHITIKN MGKGDIVILA KPLVVSKGDR GFLTTTTLLA VDGTDKPEEL LYVITSPPQF
GQVEYVRYPG VPITSFSQMD IAGQTVCYVD KSTTAVHRDT FRFIVSNGLQ TKPGVFEITL
ETVDTALPVV TRNKGLRLVE GATGLLSPDL LQLTDPDTPA EKLTFLLAQL PRHGQLYLRG
MALIPHNFTQ LDVDSGHVAY RHLGGDSWTD HFTFVATDGT NHGFLVDGRV WQEPVSFTIQ
VDQLDKAAPR VTHLHSPSQV GLLKNGCYGI YITSRVLKAS DPDTDDNQII FKILRGPQHG
HLENSTTGEF IHEKFSQKDL NSKTVLYIIN PSLEVNSDTM EFQVMDPTGN SATPQSLELN
WSYIEWSRTE YEVCENMGML PLEITRRGYS MDSAFVTVQV NQVSATVGKD FTMTPSKLVQ
FDPGMSTKMW NIAITYDGLE EDDEVFEVIL NSPVNAVLGT KTKTAVKILD SKGGQCHPSN
AFNSNMPSAW EKGIWHLLSP GASSPTTSDS FHLERRPLPT SKQLAVTRGD ALRDFGSEDL
SPVKLRTRGD GKTVPPSSVY KNRTDIIYNY HGVISLKLED DGSPARRRKA NVSFISEPQK
TTKVAEPPQA DKEESTTGSH FPRQDPLPSF PKNCTPELKG LFHFEESLQK LYKCDGIAWR
SWSPHTKEVE DKSCPAGWHH HSGYCHSLIT EQKGTWTTAA QACREHYQGS LVTVISRQHM
RWLWDISGRK PFWIGLNDQV RAGHWEWIGG EPVTFTNWRR GPPQRSRHGK DCVLVQRPGK
WHTKDCRKGK SHSYVCSRKL
//
