ID E1BPU6_BOVIN Unreviewed; 1605 AA.
AC E1BPU6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Methyl-CpG binding domain protein 5 {ECO:0000313|Ensembl:ENSBTAP00000053347.3};
GN Name=MBD5 {ECO:0000313|Ensembl:ENSBTAP00000053347.3,
GN ECO:0000313|VGNC:VGNC:31277};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000053347.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000053347.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053347.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000053347.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053347.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR PaxDb; 9913-ENSBTAP00000053347; -.
DR Ensembl; ENSBTAT00000061479.3; ENSBTAP00000053347.3; ENSBTAG00000019592.7.
DR VEuPathDB; HostDB:ENSBTAG00000019592; -.
DR VGNC; VGNC:31277; MBD5.
DR eggNOG; ENOG502QTC7; Eukaryota.
DR GeneTree; ENSGT00530000064137; -.
DR HOGENOM; CLU_003105_0_0_1; -.
DR TreeFam; TF106391; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000019592; Expressed in spermatid and 102 other cell types or tissues.
DR ExpressionAtlas; E1BPU6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR GO; GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
DR CDD; cd20141; PWWP_MBD5; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR16112; METHYL-CPG BINDING PROTEIN, DROSOPHILA; 1.
DR PANTHER; PTHR16112:SF18; METHYL-CPG-BINDING DOMAIN PROTEIN 5; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 11..81
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1496..1520
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 123..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1456..1489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1580..1605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..345
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1605 AA; 170599 MW; 6969D8F3A48E51F9 CRC64;
MNGGKECDGG DKDGGLPAIQ VPVGWQRRVD QNGVLYISPS GSLLSCLEQV KTYLLTDGTC
KCGLECPLIL PKVFNFDPGA AVKQRTAEDV KADEDVTKLC IHKRKIIAVA TLHKSMETPH
PSLVLTSPGG GTNATPVVPS RAATPRSVRN KSHEGITNSV MPECKNPFKL MIGSSNTMGR
LYVQELPGSQ QQEPHPVYPR QRLGSNEHGQ KSPFRGSHGG LPSPASSGSQ IYGDGSISPR
TDPLGSPDVF TRNNPGFHGA PNSSPIHLNR TPLSPPSVML HGSPVQSSCA MAGRTNIPLS
PTLTTKSPVM KKPMCNFSTN MEIPRAMFHH KPPQGPPPPP PSCALQKKPL TSEKDPLGIL
DPIPSKPVNQ NPVIINPTSF HSNVHSQVPV MNVSMPPAVV PLPSNLPLPT VKPGHMNHGS
HVQRVQHSAS TSLSPSPVTS PVHMMGTGIG RIEASPQRSR SSSTSSDHGN FMMPPLGPQA
NCSGIKVPPR SPRSTIGSPR PSMPSSPSTK SDGHHQYKDI PNPLIAGMSN VLNPPSSAAF
PTASAGSGSV KSQPGLLGMP LNQILNQHNA ASFPASSLLS AAAKAQLANQ NKLAGNNSSS
SSNSGAVAGS GNTEGHSTLN TMFPPTANML LPSGEGQSGR AALRDKLMSQ QKDSLRKRKQ
PPTTVLSLLR QSQMDSSAVP KPGPDLLRKQ GQGSFPISSM SQLLQSMSCQ SSHLSSNSTP
GCGGSNTALP CSANQLHFTD PSMNSSVLQN SLTQSIPLRG EAMHCHNANT NFVHSNSPVP
NHHLTGLINQ IQASGNCGML SQSGMALGNS LHPNPPQSRI STSSTPVIPN SIVSSYNQTS
SEAGGSGPSS SIAIAGINHP AITKTTSVLQ DGVIVTTAAG NPLQSQLPIG SDFPFVGQEH
ALHFPSNSTS NNHLPHPLNP SLLSSLPISL PVNQQHLLNQ NLLNIFQPSA GEAVTGASGL
MALNPQLLGG VLNSASANTA NHPEVSIATS SQATTTTTTT SSAVAALTVS TLGGTAVVSM
AETLLNISNN AGNTPGPAKL NSNSVVPQLL NPLLGTGLLG DMPSINSTLN NHQLTHLQSL
LNNNQMFPPN QQQQQLLQGY QNLQAFQGQS TIPCPANNNP MACLFQNFQV RMQEDAALLN
KRISTQPGLT ALPENPNTTL PPFQDTSCEL QSRIDPSLGQ QVKDGLIMGG QGDASVDAIY
KAVVDAASKG MQVVITTAVN STTQISPIPA LSAMSAFTAS IGDPLSLPSA VSAVIHGRNM
GSVDHDGRLR SARGARLPSS LDHGKNSSEG DGFEYFKSAG CHTSKKQWDG EQSPGGERNR
WKCEEFLDHP GHIHNSPCHE RPNNVSTLPF LPGEQHPILL PPRNCQGDKI LEENFRYNNY
KRTMMSFKER LENTVERCAH INGNRSRQSR GFGELLSTTK QDFVLEEQSP SSSNSLESSL
VKDYIHYNGD FNAKNINGCV PSPSDAKSIS SEDDLRNPDS PSSNELIPYR PRTFNVGDLV
WGQIKGLTSW PGKLVREDDV HSSCQQSPEE GKVEPEKLKT LTEGLEAYSR ARKRNRKSGK
LNNHLEAAIH EAMSELDKMS GTVHQIPQGD RQMRPPKPKR RKISR
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