ID E1BQ54_CHICK Unreviewed; 541 AA.
AC E1BQ54;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=DNA-dependent metalloprotease SPRTN {ECO:0000256|ARBA:ARBA00023885};
DE AltName: Full=Protein with SprT-like domain at the N terminus {ECO:0000256|ARBA:ARBA00030396};
GN Name=SPRTN {ECO:0000313|Ensembl:ENSGALP00010010544.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010010544.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010010544.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010010544.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Spartan family.
CC {ECO:0000256|ARBA:ARBA00010724}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_419571.4; XM_419571.5.
DR AlphaFoldDB; E1BQ54; -.
DR SMR; E1BQ54; -.
DR STRING; 9031.ENSGALP00000017996; -.
DR PaxDb; 9031-ENSGALP00000017996; -.
DR Ensembl; ENSGALT00010018995.1; ENSGALP00010010544.1; ENSGALG00010007970.1.
DR GeneID; 421530; -.
DR KEGG; gga:421530; -.
DR CTD; 83932; -.
DR VEuPathDB; HostDB:geneid_421530; -.
DR GeneTree; ENSGT00390000003585; -.
DR InParanoid; E1BQ54; -.
DR OMA; EEYRRHW; -.
DR OrthoDB; 24062at2759; -.
DR Reactome; R-GGA-110320; Translesion Synthesis by POLH.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000011065; Expressed in spermatid and 13 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR GO; GO:0106300; P:protein-DNA covalent cross-linking repair; IEA:Ensembl.
DR GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR GO; GO:0019985; P:translesion synthesis; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR044245; Spartan.
DR InterPro; IPR006640; SprT-like_domain.
DR PANTHER; PTHR21220:SF0; DNA-DEPENDENT METALLOPROTEASE SPRTN; 1.
DR PANTHER; PTHR21220; UNCHARACTERIZED; 1.
DR Pfam; PF10263; SprT-like; 1.
DR SMART; SM00731; SprT; 1.
DR SMART; SM00734; ZnF_Rad18; 1.
DR PROSITE; PS51908; ZF_UBZ4; 1.
PE 3: Inferred from homology;
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 541 AA; 61010 MW; AC24CFB5EF49D2F3 CRC64;
MRRRRRSSYE SGRSGVRMRD RTEVAVVVRG AVRVVAVARG PTAVGMEQEM QDEEDDDFAL
ALQLQELWEA EAAAGVEAPP DPASLRPLSV VDEAWELLDP SPDVHGLFVQ FNEALFWGRL
AAVEVSWSPR MTLCAGVCKY EGNGGMCSIR LSEPLLKLRP RKDLVETLLH EMIHALLFVT
NNDRDRDSHG PEFCKHMRRI NRLTGANVTI YHNFHDEVDS YRQHWWRCNG PCQYRRPYFG
YVKRSMNRAP SARDFWWAEH QENCGGTFTK VKEPENFSKK PKEKTETEKL QNSKSTNKGQ
VHLGDKKDPK PFSGNGYRLG GAGSGLSEKS VTFSSNVMNT GRSDSQHRSA GSTIPIPKNE
IKFEKSPRHD TFFPLFTGDA SEKMNLASKR EFPKLSVANT KAYKNVNGSP VKVARVVEED
SNQGSAKGKR VLPPCYNRSP KQVRFQQTAA AQTPSEKKSL ENTVQQWPRK EDQTTFENYF
IKKHPDVTSS INTPLKTKAE SAVCSPRSST AERQEKTVSC PVCQTEVLES KINEHLDSCL
V
//
