ID E1BRR7_CHICK Unreviewed; 369 AA.
AC E1BRR7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Hydroxyacid oxidase 1 {ECO:0000313|Ensembl:ENSGALP00010026668.1};
GN Name=HAO1 {ECO:0000313|Ensembl:ENSGALP00010026668.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010026668.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010026668.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010026668.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2;
CC Xref=Rhea:RHEA:67940, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:133514, ChEBI:CHEBI:176689;
CC Evidence={ECO:0000256|ARBA:ARBA00029327};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67941;
CC Evidence={ECO:0000256|ARBA:ARBA00029327};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2;
CC Xref=Rhea:RHEA:16789, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:35179, ChEBI:CHEBI:58123; EC=1.1.3.15;
CC Evidence={ECO:0000256|ARBA:ARBA00029325};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16790;
CC Evidence={ECO:0000256|ARBA:ARBA00029325};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- SIMILARITY: Belongs to the FMN-dependent alpha-hydroxy acid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00024042}.
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DR RefSeq; NP_001186371.2; NM_001199442.2.
DR AlphaFoldDB; E1BRR7; -.
DR SMR; E1BRR7; -.
DR STRING; 9031.ENSGALP00000014358; -.
DR PaxDb; 9031-ENSGALP00000014358; -.
DR Ensembl; ENSGALT00010044746.1; ENSGALP00010026668.1; ENSGALG00010018494.1.
DR GeneID; 416728; -.
DR KEGG; gga:416728; -.
DR CTD; 54363; -.
DR VEuPathDB; HostDB:geneid_416728; -.
DR GeneTree; ENSGT00390000018717; -.
DR InParanoid; E1BRR7; -.
DR OMA; RIWFRPK; -.
DR OrthoDB; 276514at2759; -.
DR Reactome; R-GGA-389661; Glyoxylate metabolism and glycine degradation.
DR Reactome; R-GGA-9033241; Peroxisomal protein import.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000008845; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005782; C:peroxisomal matrix; IEA:Ensembl.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0003973; F:(S)-2-hydroxy-acid oxidase activity; IEA:Ensembl.
DR GO; GO:0010181; F:FMN binding; IEA:Ensembl.
DR GO; GO:0047969; F:glyoxylate oxidase activity; IEA:Ensembl.
DR GO; GO:0001561; P:fatty acid alpha-oxidation; IBA:GO_Central.
DR GO; GO:0046296; P:glycolate catabolic process; IEA:Ensembl.
DR CDD; cd02809; alpha_hydroxyacid_oxid_FMN; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR012133; Alpha-hydoxy_acid_DH_FMN.
DR InterPro; IPR000262; FMN-dep_DH.
DR InterPro; IPR037396; FMN_HAD.
DR InterPro; IPR008259; FMN_hydac_DH_AS.
DR PANTHER; PTHR10578:SF137; 2-HYDROXYACID OXIDASE 1; 1.
DR PANTHER; PTHR10578; S -2-HYDROXY-ACID OXIDASE-RELATED; 1.
DR Pfam; PF01070; FMN_dh; 1.
DR PIRSF; PIRSF000138; Al-hdrx_acd_dh; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS00557; FMN_HYDROXY_ACID_DH_1; 1.
DR PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E1BRR7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
SQ SEQUENCE 369 AA; 40546 MW; 0088DBBC29370DAD CRC64;
MSGKPVCVAD FEHYAKTFLP KSVYDYYRSG ADDQETLADN VAAFSRWKLY PRVLRDVSVM
DLSTSVLGQK ISMPVCVAAT AMQRMAHPDG ETATAKACHA MGTGMMLSSW ATSSIEEVAE
AAPGGLRWLQ LYVYKDREVT KSLVKRAERA GYKGIFVTVD TPFLGRRIDD VRNKFQLPPH
LRLKNFSSNN LDFSGRDFGE DSGLAVYVAN AIDASVNWED IKWLRGLTSL PIVAKGILRA
DDAKEAVKLG VDGILVSNHG ARQLDGVPAT IDILPEIVEA VEGKVEVFLD GGIRKGTDIL
KALALGAKAV FIGRPLIWGL VYQGEEGAKE VLQMLKEEFR LAMALTGCRT VKEIGRTLIR
RHEVLLSKI
//
