ID E1BS25_CHICK Unreviewed; 729 AA.
AC E1BS25;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Solute carrier family 6 member 15 {ECO:0000313|Ensembl:ENSGALP00010015161.1};
GN Name=SLC6A15 {ECO:0000313|Ensembl:ENSGALP00010015161.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010015161.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010015161.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010015161.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:29283, ChEBI:CHEBI:29101, ChEBI:CHEBI:57972;
CC Evidence={ECO:0000256|ARBA:ARBA00034289};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:71383, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048;
CC Evidence={ECO:0000256|ARBA:ARBA00034241};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:68232, ChEBI:CHEBI:29101, ChEBI:CHEBI:35235;
CC Evidence={ECO:0000256|ARBA:ARBA00034279};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359;
CC Evidence={ECO:0000256|ARBA:ARBA00034242};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:29275, ChEBI:CHEBI:29101, ChEBI:CHEBI:58045;
CC Evidence={ECO:0000256|ARBA:ARBA00034260};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:29263, ChEBI:CHEBI:29101, ChEBI:CHEBI:57427;
CC Evidence={ECO:0000256|ARBA:ARBA00034222};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:68240, ChEBI:CHEBI:29101, ChEBI:CHEBI:57844;
CC Evidence={ECO:0000256|ARBA:ARBA00034276};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) +
CC Na(+)(out); Xref=Rhea:RHEA:68244, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00034253};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-pipecolate(in) + Na(+)(in) = L-pipecolate(out) + Na(+)(out);
CC Xref=Rhea:RHEA:71387, ChEBI:CHEBI:29101, ChEBI:CHEBI:61185;
CC Evidence={ECO:0000256|ARBA:ARBA00034235};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out);
CC Xref=Rhea:RHEA:28967, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039;
CC Evidence={ECO:0000256|ARBA:ARBA00033708};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384;
CC Evidence={ECO:0000256|ARBA:ARBA00034261};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:69999, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926;
CC Evidence={ECO:0000256|ARBA:ARBA00034271};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out);
CC Xref=Rhea:RHEA:29267, ChEBI:CHEBI:29101, ChEBI:CHEBI:57762;
CC Evidence={ECO:0000256|ARBA:ARBA00034282};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. SLC6A15 subfamily. {ECO:0000256|ARBA:ARBA00006563}.
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DR RefSeq; XP_004937652.1; XM_004937595.2.
DR RefSeq; XP_004937654.1; XM_004937597.2.
DR RefSeq; XP_015138917.1; XM_015283431.1.
DR RefSeq; XP_015138920.1; XM_015283434.1.
DR RefSeq; XP_015138926.1; XM_015283440.1.
DR RefSeq; XP_416124.1; XM_416124.5.
DR AlphaFoldDB; E1BS25; -.
DR SMR; E1BS25; -.
DR STRING; 9031.ENSGALP00000017881; -.
DR PaxDb; 9031-ENSGALP00000017881; -.
DR Ensembl; ENSGALT00010026598.1; ENSGALP00010015161.1; ENSGALG00010011117.1.
DR GeneID; 417881; -.
DR KEGG; gga:417881; -.
DR CTD; 55117; -.
DR VEuPathDB; HostDB:geneid_417881; -.
DR GeneTree; ENSGT00940000157277; -.
DR InParanoid; E1BS25; -.
DR OMA; VVFCLRY; -.
DR Reactome; R-GGA-352230; Amino acid transport across the plasma membrane.
DR Reactome; R-GGA-442660; Na+/Cl- dependent neurotransmitter transporters.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000010992; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015657; F:branched-chain amino acid:sodium symporter activity; IEA:Ensembl.
DR GO; GO:0005295; F:neutral L-amino acid:sodium symporter activity; IEA:Ensembl.
DR GO; GO:0005298; F:proline:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0015820; P:leucine transport; IBA:GO_Central.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR GO; GO:0015824; P:proline transport; IEA:Ensembl.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR CDD; cd11522; SLC6sbd_SBAT1; 1.
DR InterPro; IPR042934; B(0)AT2.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002438; Neutral_aa_SLC6.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF101; SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT2; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR PRINTS; PR01206; ORPHTRNSPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurotransmitter transport {ECO:0000256|ARBA:ARBA00022775};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 729 AA; 81578 MW; 0C0EC2395041B3D9 CRC64;
MPKNSKVVKR DLDDEVIESV KDLLSNEDSS DDAFKKSELM VGDQEEKDAD VEEGSDVEDE
RPAWNSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL VPYLILLLVI GIPLFFLELS
VGQRIRRGSI GVWNYISPKL GGIGFASCIV CFFVALYYNV IIGWSLFYFS QSFQHPLPWD
QCPLVKNASH TFVEPECEKS SATTYYWYRE ALNISSSLSE SGGLNWKMTI CLLAAWVMVC
LAMIKGIQSS GKIMYFSSLF PYVVLLCFLV RGLLLNGSLD GIRHMLTPKL EIMLEPKVWR
EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL VVFAVLGFKA
NIINEKCVIQ NSEKILKLLK TGNLSQDMIP HHINFSSITA EDYNLVYDII QKVKEEEFES
LGLKSCQIED ELGKAVQGTG LAFIAFTEAM THFPASPFWS VMFFLMLVNL GLGSMFGTIE
GIITPIVDTF KIRKEILTVI CCLVAFFIGL IFVQRSGNYF VTMFDDYSAT LPLLIVVILE
NIAVTRIYGI EKFMEDLKDM LGFSPSQYYY YMWKYISPLV LLCLLVASIV QMGLSPPGYN
AWIEDTATEE FHSYPTWGMM VCISLMVLAI LPVPIVLIVR RCNLIDDSSG SLASVSYKRG
RIIKEPVNLE GDNTSLIHGK SPSEVPSPNF GKNIYRKQTG SPTLDTAPNG RYGIGYLMAD
MPDMPESDL
//
