ID E1BS74_CHICK Unreviewed; 379 AA.
AC E1BS74;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=G protein subunit alpha L {ECO:0000313|Ensembl:ENSGALP00010001675.1};
GN Name=GNAL {ECO:0000313|Ensembl:ENSGALP00010001675.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010001675.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010001675.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010001675.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(s) subfamily.
CC {ECO:0000256|ARBA:ARBA00007172}.
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DR RefSeq; NP_001008746.1; NM_001008746.1.
DR RefSeq; XP_015137968.1; XM_015282482.1.
DR AlphaFoldDB; E1BS74; -.
DR SMR; E1BS74; -.
DR STRING; 9031.ENSGALP00000022345; -.
DR PaxDb; 9031-ENSGALP00000022345; -.
DR Ensembl; ENSGALT00010003218.1; ENSGALP00010001675.1; ENSGALG00010001395.1.
DR GeneID; 474379; -.
DR KEGG; gga:474379; -.
DR CTD; 2774; -.
DR VEuPathDB; HostDB:geneid_474379; -.
DR GeneTree; ENSGT00940000155271; -.
DR InParanoid; E1BS74; -.
DR OMA; KEFFEHA; -.
DR OrthoDB; 2897309at2759; -.
DR Reactome; R-GGA-170660; Adenylate cyclase activating pathway.
DR Reactome; R-GGA-170670; Adenylate cyclase inhibitory pathway.
DR Reactome; R-GGA-381753; Olfactory Signaling Pathway.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000013785; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000367; Gprotein_alpha_S.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF233; GUANINE NUCLEOTIDE-BINDING PROTEIN G(OLF) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00443; GPROTEINAS.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E1BS74};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 379 AA; 44310 MW; 0D99B94E2B48D096 CRC64;
MGCLGNSKTE DQRIDEKAQR EANKKIEKQL QKERLAYKAT HRLLLLGAGE SGKSTIVKQM
RILHVNGFNS EEKKQKILDI RKNVKDAIVT IVSAMSTLIP PVPLANPENQ FRMDYIKSIA
PLSDFDYTQE FFEHAKKLWD DEGVKACFER SNEYQLIDCA QYFLERIDSV SMDDYTPTDQ
DLLRCRVLTS GIFETRFQVD KVNFHMFDVG GQRDERRKWI QCFNDVTAII FVVACSSYNM
VIREDNNTNR LRESLDLFKS IWNNRWLRTI SIILFLNKQD MLAEKVLAGK SKIEDYFPEY
AHYTVPEDAT PDAGEDPKVT RAKFFIRDEF LRISTASGDG RHYCYPHFTC AVDTENIRRV
FNDCRDIIQR MHLRQYELL
//
