ID E1BZW7_CHICK Unreviewed; 194 AA.
AC E1BZW7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
DE Short=FGF {ECO:0000256|RuleBase:RU049442};
GN Name=FGF4 {ECO:0000313|Ensembl:ENSGALP00010038439.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010038439.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010038439.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010038439.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000256|ARBA:ARBA00007936, ECO:0000256|RuleBase:RU049442}.
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DR AlphaFoldDB; E1BZW7; -.
DR SMR; E1BZW7; -.
DR Ensembl; ENSGALT00010062193.1; ENSGALP00010038439.1; ENSGALG00010025483.1.
DR VEuPathDB; HostDB:geneid_428857; -.
DR GeneTree; ENSGT00940000158825; -.
DR InParanoid; E1BZW7; -.
DR OMA; ENPYSEC; -.
DR OrthoDB; 2883843at2759; -.
DR Reactome; R-GGA-109704; PI3K Cascade.
DR Reactome; R-GGA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-GGA-190322; FGFR4 ligand binding and activation.
DR Reactome; R-GGA-190372; FGFR3c ligand binding and activation.
DR Reactome; R-GGA-190373; FGFR1c ligand binding and activation.
DR Reactome; R-GGA-190375; FGFR2c ligand binding and activation.
DR Reactome; R-GGA-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-GGA-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-GGA-5654227; Phospholipase C-mediated cascade, FGFR3.
DR Reactome; R-GGA-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-GGA-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-GGA-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-GGA-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-GGA-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-GGA-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-GGA-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-GGA-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-GGA-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-GGA-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-GGA-5654710; PI-3K cascade:FGFR3.
DR Reactome; R-GGA-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-GGA-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-GGA-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-GGA-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-GGA-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-GGA-5654732; Negative regulation of FGFR3 signaling.
DR Reactome; R-GGA-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-GGA-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-GGA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-GGA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000007562; Expressed in skeletal muscle tissue.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0060561; P:apoptotic process involved in morphogenesis; IEA:Ensembl.
DR GO; GO:0001502; P:cartilage condensation; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0060591; P:chondroblast differentiation; IEA:Ensembl.
DR GO; GO:0060363; P:cranial suture morphogenesis; IEA:Ensembl.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:1904019; P:epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:2000544; P:regulation of endothelial cell chemotaxis to fibroblast growth factor; IEA:Ensembl.
DR GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR CDD; cd00058; FGF; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR PANTHER; PTHR11486:SF31; FIBROBLAST GROWTH FACTOR 4; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR PRINTS; PR00262; IL1HBGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU049442}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU049442"
FT CHAIN 24..194
FT /note="Fibroblast growth factor"
FT /evidence="ECO:0000256|RuleBase:RU049442"
FT /id="PRO_5036530275"
SQ SEQUENCE 194 AA; 21650 MW; BB175570BA2735CA CRC64;
MPLPAALLPA LLLGLLWPGA VRGRPPPGRL PAGPRQRRWD AALFARSVAR LPAERRDAAR
DGDYLLGIKR LRRLYCNVGI GFHIQVLPDG RIDGIHSENR YSLLEISPVE RGVVSIFGVR
SGLFVAMNSK GKLYGSTHFN DECKFKEILL PNNYNAYESR IYPGMYIALS KNGRTKKGNK
VSPTMTVTHF LPRI
//
