ID E1C0T2_CHICK Unreviewed; 404 AA.
AC E1C0T2;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Bone morphogenetic protein 4 {ECO:0000256|ARBA:ARBA00035683};
GN Name=BMP4 {ECO:0000313|EMBL:QBB02363.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:QBB02363.1};
RN [1] {ECO:0000313|EMBL:QBB02363.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bone marrow {ECO:0000313|EMBL:QBB02363.1};
RA Divya D., Gnana Prakash M., Chatterjee R.N., Bhattacharya T.K.;
RT "Characterization of Bone morphogenetic protein 4 (BMP4) in layer and
RT broiler chicken.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MH553645; QBB02363.1; -; mRNA.
DR RefSeq; NP_990568.3; NM_205237.3.
DR AlphaFoldDB; E1C0T2; -.
DR SMR; E1C0T2; -.
DR GeneID; 396165; -.
DR KEGG; gga:396165; -.
DR CTD; 652; -.
DR VEuPathDB; HostDB:geneid_396165; -.
DR HOGENOM; CLU_020515_4_2_1; -.
DR InParanoid; E1C0T2; -.
DR Reactome; R-GGA-2129379; Molecules associated with elastic fibres.
DR Reactome; R-GGA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-GGA-8957275; Post-translational protein phosphorylation.
DR Bgee; ENSGALG00000012429; Expressed in cerebellum and 11 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR CDD; cd19391; TGF_beta_BMP4_BMP2B; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR047833; BMP4_TGF_beta-like.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF165; BONE MORPHOGENETIC PROTEIN 4; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 287..404
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 404 AA; 46017 MW; 7081CE433B342582 CRC64;
MIPGNRMLMV ILLCQVLLGG TNHASLIPET GRKKVAELQG QAGSGRRSAQ SHELLRGFET
TLLQMFGLRR RPQPSKSAVI PSYMLDLYRL QSGEEEESLQ EISLQYPERS TSRANTVRSF
HHEEHLESVP GPSEVPRIRF VFNLSSVPDN EVISSAELRL YREQVEEPSA AWERGFHRIN
IYEVMKPLSE RSQAITRLLD TRLVHHNVTR WETFDVSPAV IRWTKDKQPN HGLVIEVTHL
HQAQTHQGKH VRISRSLPQG YGGDWAQLRP LLVTFGHDGR GHALTRRARR SPKHQRSRKN
KKNCRRHALY VDFSDVGWND WIVAPPGYQA FYCHGDCPFP LADHLNSTNH AIVQTLVNSV
NSSIPKACCV PTELSAISML YLDEYDKVVL KNYQEMVVEG CGCR
//
